Literature DB >> 2161386

Superoxide-dependent formation of hydroxyl radicals from ferric-complexes and hydrogen peroxide: an evaluation of fourteen iron chelators.

J M Gutteridge1.   

Abstract

When a variety of ferric chelates are reacted with hydrogen peroxide in phosphate buffer deoxyribose is damaged and this damage is protected against by formate, thiourea and mannitol. Damage done by ferric complexes of citrate, EDTA, NTA, EGTA and HEDA is substantially inhibited by superoxide dismutase (SOD) whereas complexes of PLA, ADP and CDTA are moderately inhibited by SOD. The effects of SOD argue against hydrogen peroxide acting as a reductant in Fenton chemistry driven by ferric complexes and hydrogen peroxide. EDTA has proved to be a useful model for Fenton chemistry that is inhibited by SOD although, it is not unique in this respect.

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Year:  1990        PMID： 2161386     DOI： 10.3109/10715769009148579

Source DB:  PubMed          Journal:  Free Radic Res Commun        ISSN： 8755-0199


  9 in total

1.  Haem oxygenase shows pro-oxidant activity in microsomal and cellular systems: implications for the release of low-molecular-mass iron.

Authors:  N J Lamb; G J Quinlan; S Mumby; T W Evans; J M Gutteridge
Journal:  Biochem J       Date:  1999-11-15       Impact factor: 3.857

Review 2.  Potential therapeutic benefits of strategies directed to mitochondria.

Authors:  Amadou K S Camara; Edward J Lesnefsky; David F Stowe
Journal:  Antioxid Redox Signal       Date:  2010-08-01       Impact factor: 8.401

Review 3.  Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function.

Authors:  David F Stowe; Amadou K S Camara
Journal:  Antioxid Redox Signal       Date:  2009-06       Impact factor: 8.401

4.  Cytotoxic iron chelators: characterization of the structure, solution chemistry and redox activity of ligands and iron complexes of the di-2-pyridyl ketone isonicotinoyl hydrazone (HPKIH) analogues.

Authors:  Paul V Bernhardt; Lorraine M Caldwell; Timothy B Chaston; Piao Chin; Des R Richardson
Journal:  J Biol Inorg Chem       Date:  2003-10-15       Impact factor: 3.358

5.  Interactions of the pyridine-2-carboxaldehyde isonicotinoyl hydrazone class of chelators with iron and DNA: implications for toxicity in the treatment of iron overload disease.

Authors:  Timothy B Chaston; Des R Richardson
Journal:  J Biol Inorg Chem       Date:  2003-02-05       Impact factor: 3.358

6.  Effects of quin2 acetoxymethyl ester on H2O2-induced DNA single-strand breakage in mammalian cells: H2O2-concentration-dependent inhibition of damage and additive protective effect with the hydroxyl-radical scavenger dimethyl sulphoxide.

Authors:  B E Sandström
Journal:  Biochem J       Date:  1995-01-01       Impact factor: 3.857

7.  Superoxide dismutase activity of the captopril-iron complex.

Authors:  D Jay; A Cuella; E Jay
Journal:  Mol Cell Biochem       Date:  1995-05-10       Impact factor: 3.396

8.  Iron supplementation generates hydroxyl radical in vivo. An ESR spin-trapping investigation.

Authors:  M B Kadiiska; M J Burkitt; Q H Xiang; R P Mason
Journal:  J Clin Invest       Date:  1995-09       Impact factor: 14.808

9.  Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide.

Authors:  N Hogg; V M Darley-Usmar; M T Wilson; S Moncada
Journal:  Biochem J       Date:  1992-01-15       Impact factor: 3.857
  9 in total

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