Literature DB >> 21607873

Analysis of GPCR localization and trafficking.

James N Hislop1, Mark von Zastrow.   

Abstract

Localization and trafficking of G protein-coupled receptors (GPCRs) is increasingly recognized to play a fundamental role in receptor-mediated signaling and its regulation. Individual receptors, including closely homologous subtypes with otherwise similar functional properties, can differ considerably in their membrane trafficking properties. In this chapter, we describe several approaches for experimentally assessing the subcellular localization and trafficking of selected GPCRs. Firstly, we describe a flexible method for receptor localization using fluorescence microscopy. We then describe two complementary approaches, using fluorescence flow cytometry and surface biotinylation, for examining receptor internalization and trafficking in the endocytic pathway.

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Year:  2011        PMID： 21607873      PMCID： PMC4960980          DOI： 10.1007/978-1-61779-126-0_25

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  15 in total

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Journal:  Trends Pharmacol Sci       Date:  2001-02       Impact factor: 14.819

5.  High-density mapping of single-molecule trajectories with photoactivated localization microscopy.

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Journal:  J Cell Biol       Date:  1999-01-11       Impact factor: 10.539
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Review 4.  Methods for Studying Endocytotic Pathways of Herpesvirus Encoded G Protein-Coupled Receptors.

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Review 5.  Approaches to Visualising Endocytosis of LDL-Related Lipoproteins.

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Review 7.  Fluorogen activating protein toolset for protein trafficking measurements.

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  7 in total

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