OBJECTIVE: To compare risk factors, stroke characteristics, and long-term prognosis between nondiabetic young ischemic stroke patients and similar patients having either type 1 diabetes mellitus (T1D) or type 2 diabetes mellitus (T2D) to provide information for patient management, counseling, and future research in these patient groups. METHODS: Our database comprised 1,008 consecutive patients aged 15 to 49 with first-ever ischemic stroke from 1994 to 2007. Primary outcome measures were 1) nonfatal or fatal recurrent ischemic stroke and 2) composite vascular endpoint (myocardial infarction, any stroke, revascularization, or vascular death). RESULTS: Compared with nondiabetic stroke patients (n = 904), patients with T1D (44) or T2D (60) were more likely to have hypertension and stroke attributable to small-vessel disease (SVD). In addition, when compared with nondiabetic patients, those with T1D more frequently had coronary heart disease and peripheral arterial disease (PAD) and those with T2D more often had obesity, PAD, history of TIA, and stroke attributable to large-artery atherosclerosis, and T2D patients were also more likely to be older and male than were the nondiabetic patients. Mean follow-up in survivors was 9.0 (±3.8) years. Cumulative recurrent ischemic stroke rate at 10 years was 40.9% for T1D (14 events), 29.7% for T2D (15), and 12.0% for nondiabetic patients (94). Corresponding rates for the composite vascular endpoint were 65.1% for T1D (25), 46.9% for T2D (28), and 19.3% for nondiabetic patients (153). CONCLUSIONS: Our findings suggest that ischemic stroke patients with T1D or T2D exhibit a distinct risk-factor and etiologic profile and a worse vascular prognosis than do nondiabetic patients.
OBJECTIVE: To compare risk factors, stroke characteristics, and long-term prognosis between nondiabetic young ischemic strokepatients and similar patients having either type 1 diabetes mellitus (T1D) or type 2 diabetes mellitus (T2D) to provide information for patient management, counseling, and future research in these patient groups. METHODS: Our database comprised 1,008 consecutive patients aged 15 to 49 with first-ever ischemic stroke from 1994 to 2007. Primary outcome measures were 1) nonfatal or fatal recurrent ischemic stroke and 2) composite vascular endpoint (myocardial infarction, any stroke, revascularization, or vascular death). RESULTS: Compared with nondiabetic strokepatients (n = 904), patients with T1D (44) or T2D (60) were more likely to have hypertension and stroke attributable to small-vessel disease (SVD). In addition, when compared with nondiabeticpatients, those with T1D more frequently had coronary heart disease and peripheral arterial disease (PAD) and those with T2D more often had obesity, PAD, history of TIA, and stroke attributable to large-artery atherosclerosis, and T2D patients were also more likely to be older and male than were the nondiabeticpatients. Mean follow-up in survivors was 9.0 (±3.8) years. Cumulative recurrent ischemic stroke rate at 10 years was 40.9% for T1D (14 events), 29.7% for T2D (15), and 12.0% for nondiabeticpatients (94). Corresponding rates for the composite vascular endpoint were 65.1% for T1D (25), 46.9% for T2D (28), and 19.3% for nondiabeticpatients (153). CONCLUSIONS: Our findings suggest that ischemic strokepatients with T1D or T2D exhibit a distinct risk-factor and etiologic profile and a worse vascular prognosis than do nondiabeticpatients.
Authors: Barbara Goeggel Simonetti; Marie-Luise Mono; Uyen Huynh-Do; Patrik Michel; Celine Odier; Roman Sztajzel; Philippe Lyrer; Stefan T Engelter; Leo Bonati; Henrik Gensicke; Christopher Traenka; Barbara Tettenborn; Bruno Weder; Urs Fischer; Aekaterini Galimanis; Simon Jung; Rudolf Luedi; Gian Marco De Marchis; Anja Weck; Carlo W Cereda; Ralf Baumgartner; Claudio L Bassetti; Heinrich P Mattle; Krassen Nedeltchev; Marcel Arnold Journal: J Neurol Date: 2015-06-12 Impact factor: 4.849
Authors: Justin B Echouffo-Tcheugui; Haolin Xu; Roland A Matsouaka; Ying Xian; Lee H Schwamm; Eric E Smith; Deepak L Bhatt; Adrian F Hernandez; Paul A Heidenreich; Gregg C Fonarow Journal: Eur Heart J Date: 2018-07-01 Impact factor: 29.983
Authors: Tracy E Madsen; Jane C Khoury; Kathleen A Alwell; Charles J Moomaw; Stacie L Demel; Matthew L Flaherty; Daniel Woo; Jason Mackey; Felipe De Los Rios La Rosa; Sharyl Martini; Simona Ferioli; Opeolu Adeoye; Pooja Khatri; Brett M Kissela; Dawn Kleindorfer Journal: J Diabetes Date: 2017-08-09 Impact factor: 4.006
Authors: Yong-Won Shin; Soon-Tae Lee; Keun-Hwa Jung; Do-Yong Kim; Chul-Kee Park; Tae Min Kim; Seung Hong Choi; Kon Chu; Sang Kun Lee Journal: J Neurooncol Date: 2016-03-11 Impact factor: 4.130
Authors: Jane C Khoury; Dawn Kleindorfer; Kathleen Alwell; Charles J Moomaw; Daniel Woo; Opeolu Adeoye; Matthew L Flaherty; Pooja Khatri; Simona Ferioli; Joseph P Broderick; Brett M Kissela Journal: Stroke Date: 2013-04-25 Impact factor: 7.914
Authors: Christopher D Anderson; Alessandro Biffi; Michael A Nalls; William J Devan; Kristin Schwab; Alison M Ayres; Valerie Valant; Owen A Ross; Natalia S Rost; Richa Saxena; Anand Viswanathan; Bradford B Worrall; Thomas G Brott; Joshua N Goldstein; Devin Brown; Joseph P Broderick; Bo Norrving; Steven M Greenberg; Scott L Silliman; Björn M Hansen; David L Tirschwell; Arne Lindgren; Agnieszka Slowik; Reinhold Schmidt; Magdy Selim; Jaume Roquer; Joan Montaner; Andrew B Singleton; Chelsea S Kidwell; Daniel Woo; Karen L Furie; James F Meschia; Jonathan Rosand Journal: Stroke Date: 2013-01-29 Impact factor: 7.914