Literature DB >> 21604203

The role of mitochondria in neurodegenerative diseases.

Massimiliano Filosto1, Mauro Scarpelli, Maria Sofia Cotelli, Valentina Vielmi, Alice Todeschini, Valeria Gregorelli, Paola Tonin, Giuliano Tomelleri, Alessandro Padovani.   

Abstract

Mitochondria are implicated in several metabolic pathways including cell respiratory processes, apoptosis, and free radical production. Mitochondrial abnormalities have been documented in neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's diseases, and amyotrophic lateral sclerosis. Several studies have demonstrated that mitochondrial impairment plays an important role in the pathogenesis of this group of disorders. In this review, we discuss the role of mitochondria in the main neurodegenerative diseases and review the updated knowledge in this field.

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Year:  2011        PMID： 21604203     DOI： 10.1007/s00415-011-6104-z

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  158 in total

1.  Detection of DNA base-excision repair activity for oxidative lesions in adult rat brain mitochondria.

Authors:  D Chen; J Lan; W Pei; J Chen
Journal:  J Neurosci Res       Date:  2000-07-15       Impact factor: 4.164

2.  Deleted 4977-bp mitochondrial DNA mutation is associated with sporadic amyotrophic lateral sclerosis: a hospital-based case-control study.

Authors:  Long-Sun Ro; Shiao-Lin Lai; Chiung-Mei Chen; Sien-Tsong Chen
Journal:  Muscle Nerve       Date:  2003-12       Impact factor: 3.217

3.  Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A.

Authors:  Stephan Züchner; Irina V Mersiyanova; Maria Muglia; Nisrine Bissar-Tadmouri; Julie Rochelle; Elena L Dadali; Mario Zappia; Eva Nelis; Alessandra Patitucci; Jan Senderek; Yesim Parman; Oleg Evgrafov; Peter De Jonghe; Yuji Takahashi; Shoij Tsuji; Margaret A Pericak-Vance; Aldo Quattrone; Esra Battaloglu; Alexander V Polyakov; Vincent Timmerman; J Michael Schröder; Jeffery M Vance; Esra Battologlu
Journal:  Nat Genet       Date:  2004-04-04       Impact factor: 38.330

4.  High frequency of mitochondrial complex I mutations in Parkinson's disease and aging.

Authors:  Rafal Smigrodzki; Janice Parks; W Davis Parker
Journal:  Neurobiol Aging       Date:  2004 Nov-Dec       Impact factor: 4.673

Review 5.  Alzheimer's disease.

Authors:  Henry W Querfurth; Frank M LaFerla
Journal:  N Engl J Med       Date:  2010-01-28       Impact factor: 91.245

Review 6.  Oxidative stress and altered mitochondrial function in neurodegenerative diseases: lessons from mouse models.

Authors:  J C Fernández-Checa; A Fernández; A Morales; M Marí; C García-Ruiz; A Colell
Journal:  CNS Neurol Disord Drug Targets       Date:  2010-08       Impact factor: 4.388

Review 7.  Amyotrophic lateral sclerosis.

Authors:  J Jefferson P Perry; David S Shin; John A Tainer
Journal:  Adv Exp Med Biol       Date:  2010       Impact factor: 2.622

8.  Mitochondrial DNA haplogroups J and K are not protective for Parkinson's disease in the Australian community.

Authors:  Prachi Mehta; George D Mellick; Dominic B Rowe; Glenda M Halliday; Michael M Jones; Neil Manwaring; Himesha Vandebona; Peter A Silburn; Jie Jin Wang; Paul Mitchell; Carolyn M Sue
Journal:  Mov Disord       Date:  2009-01-30       Impact factor: 10.338

9.  Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice.

Authors:  Virginie Rhein; Xiaomin Song; Andreas Wiesner; Lars M Ittner; Ginette Baysang; Fides Meier; Laurence Ozmen; Horst Bluethmann; Stefan Dröse; Ulrich Brandt; Egemen Savaskan; Christian Czech; Jürgen Götz; Anne Eckert
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-06       Impact factor: 11.205

10.  The PINK1/Parkin pathway regulates mitochondrial morphology.

Authors:  Angela C Poole; Ruth E Thomas; Laurie A Andrews; Heidi M McBride; Alexander J Whitworth; Leo J Pallanck
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-29       Impact factor: 11.205
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  47 in total

1.  ATP Synthase Subunit Beta Immunostaining is Reduced in the Sclerotic Hippocampus of Epilepsy Patients.

Authors:  Marcelo Vilas Boas Mota; Bruna Cunha Zaidan; Amanda Morato do Canto; Enrico Ghizoni; Helder Tedeschi; Luciano de Souza Queiroz; Marina K M Alvim; Fernando Cendes; Iscia Lopes-Cendes; André Almeida Schenka; André Schwambach Vieira; Fabio Rogerio
Journal:  Cell Mol Neurobiol       Date:  2018-12-11       Impact factor: 5.046

2.  GNE Myopathy and Cell Apoptosis: A Comparative Mutation Analysis.

Authors:  Reema Singh; Ranjana Arya
Journal:  Mol Neurobiol       Date:  2015-05-15       Impact factor: 5.590

3.  Common mechanism unites membrane poration by amyloid and antimicrobial peptides.

Authors:  Nicholas B Last; Andrew D Miranker
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-01       Impact factor: 11.205

Review 4.  Long non-coding RNA: Functional agent for disease traits.

Authors:  Sriyans Jain; Nirav Thakkar; Jagamohan Chhatai; Manika Pal Bhadra; Utpal Bhadra
Journal:  RNA Biol       Date:  2016-05-26       Impact factor: 4.652

5.  Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis.

Authors:  Ying Wang; Daniella Oxer; Siegfried Hekimi
Journal:  Nat Commun       Date:  2015-03-06       Impact factor: 14.919

6.  Modulating effect of tiron on the capability of mitochondrial oxidative phosphorylation in the brain of rats exposed to radiation or manganese toxicity.

Authors:  Nadia Abdel-Magied; Nahed Abdel-Aziz; Shereen M Shedid; Amal G Ahmed
Journal:  Environ Sci Pollut Res Int       Date:  2019-03-08       Impact factor: 4.223

Review 7.  Mitochondrial biogenesis as a therapeutic target for traumatic and neurodegenerative CNS diseases.

Authors:  Epiphani C Simmons; Natalie E Scholpa; Rick G Schnellmann
Journal:  Exp Neurol       Date:  2020-04-11       Impact factor: 5.330

Review 8.  Autophagy of mitochondria: a promising therapeutic target for neurodegenerative disease.

Authors:  Pradip K Kamat; Anuradha Kalani; Philip Kyles; Suresh C Tyagi; Neetu Tyagi
Journal:  Cell Biochem Biophys       Date:  2014-11       Impact factor: 2.194

9.  Effects of Novel Tacrine Derivatives on Mitochondrial Energy Metabolism and Monoamine Oxidase Activity-In Vitro Study.

Authors:  Jana Hroudová; Tereza Nováková; Jan Korábečný; Dávid Maliňák; Lukáš Górecki; Zdeněk Fišar
Journal:  Mol Neurobiol       Date:  2020-10-22       Impact factor: 5.590

Review 10.  Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease.

Authors:  Renato X Santos; Sónia C Correia; Xiongwei Zhu; Mark A Smith; Paula I Moreira; Rudy J Castellani; Akihiko Nunomura; George Perry
Journal:  Antioxid Redox Signal       Date:  2012-12-07       Impact factor: 8.401
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