Literature DB >> 27229269

Long non-coding RNA: Functional agent for disease traits.

Sriyans Jain1, Nirav Thakkar1, Jagamohan Chhatai1, Manika Pal Bhadra2, Utpal Bhadra1.   

Abstract

In recent years, long non-coding RNAs (lncRNAs) have attracted the attention of researchers with their involvement in all facets of life. LncRNAs are transcripts of more than 200 nucleotides which lack defined protein coding potential. Although they do not code for proteins, a large number of them are involved in regulating gene expression and translation. The presence of numerous lncRNAs in the human genome has prompted us to investigate the contribution of these molecules to human biology and medicine. In this review, we present the potential role of lncRNAs interlinked to different human diseases and genetic disorders. We also describe their role in cellular differentiation and aging and discuss their potential importance as biomarkers and as therapeutic agents.

Entities:  

Keywords:  Biomarkers; epigenetics; gene regulation; human diseases; long non-coding RNA; therapeutic agents

Mesh：

Substances：

Year:  2016        PMID： 27229269      PMCID： PMC5449085          DOI： 10.1080/15476286.2016.1172756

Source DB:  PubMed          Journal:  RNA Biol        ISSN： 1547-6286            Impact factor:   4.652


  139 in total

1.  CVD-associated non-coding RNA, ANRIL, modulates expression of atherogenic pathways in VSMC.

Authors:  Ada Congrains; Kei Kamide; Tomohiro Katsuya; Osamu Yasuda; Ryousuke Oguro; Koichi Yamamoto; Mitsuru Ohishi; Hiromi Rakugi
Journal:  Biochem Biophys Res Commun       Date:  2012-02-20       Impact factor: 3.575

2.  Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

Authors:  Lucia A Hindorff; Praveen Sethupathy; Heather A Junkins; Erin M Ramos; Jayashri P Mehta; Francis S Collins; Teri A Manolio
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-27       Impact factor: 11.205

Review 3.  Non-coding RNAs: regulators of disease.

Authors:  Ryan J Taft; Ken C Pang; Timothy R Mercer; Marcel Dinger; John S Mattick
Journal:  J Pathol       Date:  2010-01       Impact factor: 7.996

4.  Prognostic significance of long non-coding RNA PCAT-1 expression in human hepatocellular carcinoma.

Authors:  Ting-Hua Yan; Hong Yang; Jin-Hua Jiang; Sui-Wan Lu; Chun-Xian Peng; Hua-Xing Que; Wei-Li Lu; Jian-Feng Mao
Journal:  Int J Clin Exp Pathol       Date:  2015-04-01

5.  Long noncoding RNA GAS5: a novel marker involved in glucocorticoid response.

Authors:  M Lucafo; S De Iudicibus; A Di Silvestre; M Pelin; L Candussio; S Martelossi; A Tommasini; E Piscianz; A Ventura; G Decorti
Journal:  Curr Mol Med       Date:  2015       Impact factor: 2.222

6.  A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition.

Authors:  Manuel Beltran; Isabel Puig; Cristina Peña; José Miguel García; Ana Belén Alvarez; Raúl Peña; Félix Bonilla; Antonio García de Herreros
Journal:  Genes Dev       Date:  2008-03-15       Impact factor: 11.361

7.  Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase.

Authors:  Mohammad Ali Faghihi; Farzaneh Modarresi; Ahmad M Khalil; Douglas E Wood; Barbara G Sahagan; Todd E Morgan; Caleb E Finch; Georges St Laurent; Paul J Kenny; Claes Wahlestedt
Journal:  Nat Med       Date:  2008-06-29       Impact factor: 53.440

8.  The transcriptional landscape of the mammalian genome.

Authors:  P Carninci; T Kasukawa; S Katayama; J Gough; M C Frith; N Maeda; R Oyama; T Ravasi; B Lenhard; C Wells; R Kodzius; K Shimokawa; V B Bajic; S E Brenner; S Batalov; A R R Forrest; M Zavolan; M J Davis; L G Wilming; V Aidinis; J E Allen; A Ambesi-Impiombato; R Apweiler; R N Aturaliya; T L Bailey; M Bansal; L Baxter; K W Beisel; T Bersano; H Bono; A M Chalk; K P Chiu; V Choudhary; A Christoffels; D R Clutterbuck; M L Crowe; E Dalla; B P Dalrymple; B de Bono; G Della Gatta; D di Bernardo; T Down; P Engstrom; M Fagiolini; G Faulkner; C F Fletcher; T Fukushima; M Furuno; S Futaki; M Gariboldi; P Georgii-Hemming; T R Gingeras; T Gojobori; R E Green; S Gustincich; M Harbers; Y Hayashi; T K Hensch; N Hirokawa; D Hill; L Huminiecki; M Iacono; K Ikeo; A Iwama; T Ishikawa; M Jakt; A Kanapin; M Katoh; Y Kawasawa; J Kelso; H Kitamura; H Kitano; G Kollias; S P T Krishnan; A Kruger; S K Kummerfeld; I V Kurochkin; L F Lareau; D Lazarevic; L Lipovich; J Liu; S Liuni; S McWilliam; M Madan Babu; M Madera; L Marchionni; H Matsuda; S Matsuzawa; H Miki; F Mignone; S Miyake; K Morris; S Mottagui-Tabar; N Mulder; N Nakano; H Nakauchi; P Ng; R Nilsson; S Nishiguchi; S Nishikawa; F Nori; O Ohara; Y Okazaki; V Orlando; K C Pang; W J Pavan; G Pavesi; G Pesole; N Petrovsky; S Piazza; J Reed; J F Reid; B Z Ring; M Ringwald; B Rost; Y Ruan; S L Salzberg; A Sandelin; C Schneider; C Schönbach; K Sekiguchi; C A M Semple; S Seno; L Sessa; Y Sheng; Y Shibata; H Shimada; K Shimada; D Silva; B Sinclair; S Sperling; E Stupka; K Sugiura; R Sultana; Y Takenaka; K Taki; K Tammoja; S L Tan; S Tang; M S Taylor; J Tegner; S A Teichmann; H R Ueda; E van Nimwegen; R Verardo; C L Wei; K Yagi; H Yamanishi; E Zabarovsky; S Zhu; A Zimmer; W Hide; C Bult; S M Grimmond; R D Teasdale; E T Liu; V Brusic; J Quackenbush; C Wahlestedt; J S Mattick; D A Hume; C Kai; D Sasaki; Y Tomaru; S Fukuda; M Kanamori-Katayama; M Suzuki; J Aoki; T Arakawa; J Iida; K Imamura; M Itoh; T Kato; H Kawaji; N Kawagashira; T Kawashima; M Kojima; S Kondo; H Konno; K Nakano; N Ninomiya; T Nishio; M Okada; C Plessy; K Shibata; T Shiraki; S Suzuki; M Tagami; K Waki; A Watahiki; Y Okamura-Oho; H Suzuki; J Kawai; Y Hayashizaki
Journal:  Science       Date:  2005-09-02       Impact factor: 47.728

Review 9.  Role of MALAT1 as a Prognostic Factor for Survival in Various Cancers: A Systematic Review of the Literature with Meta-Analysis.

Authors:  Yao Wei; Ben Niu
Journal:  Dis Markers       Date:  2015-09-02       Impact factor: 3.434

10.  Plasma HULC as a promising novel biomarker for the detection of hepatocellular carcinoma.

Authors:  Hui Xie; Hongwei Ma; Danqiu Zhou
Journal:  Biomed Res Int       Date:  2013-05-22       Impact factor: 3.411
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  31 in total

1.  RNA in Disease and development.

Authors:  Andrea Barta; Michael F Jantsch
Journal:  RNA Biol       Date:  2017-05-04       Impact factor: 4.652

Review 2.  The RNA world of human ageing.

Authors:  J C Gomez-Verjan; E R Vazquez-Martinez; N A Rivero-Segura; R H Medina-Campos
Journal:  Hum Genet       Date:  2018-11-01       Impact factor: 4.132

3.  A novel human lncRNA SANT1 cis-regulates the expression of SLC47A2 by altering SFPQ/E2F1/HDAC1 binding to the promoter region in renal cell carcinoma.

Authors:  Zhangzhao Gao; Mengjiao Chen; Xueke Tian; Lu Chen; Le Chen; Xiaoli Zheng; Hua Wang; Jinchao Chen; An Zhao; Qingqing Yao; Qianying Zhu; Shengnan Jin; Haihong Hu; Su Zeng; Lushan Yu
Journal:  RNA Biol       Date:  2019-04-21       Impact factor: 4.652

4.  LncXIST Facilitates Iron Overload and Iron Overload-Induced Islet Beta Cell Injury in Type 2 Diabetes through miR-130a-3p/ALK2 Axis.

Authors:  Weiyuan Li; Qiu Feng; Chenrong Wang; Zhao Yin; Xiaolu Li; Lei Li
Journal:  Comput Intell Neurosci       Date:  2022-06-09

5.  DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining.

Authors:  Adil Salhi; Magbubah Essack; Tanvir Alam; Vladan P Bajic; Lina Ma; Aleksandar Radovanovic; Benoit Marchand; Sebastian Schmeier; Zhang Zhang; Vladimir B Bajic
Journal:  RNA Biol       Date:  2017-04-07       Impact factor: 4.652

6.  Comprehensive analysis of the association between UBAC2 polymorphisms and Behçet's disease in a Japanese population.

Authors:  Kyoko Yamazoe; Akira Meguro; Masaki Takeuchi; Etsuko Shibuya; Shigeaki Ohno; Nobuhisa Mizuki
Journal:  Sci Rep       Date:  2017-04-07       Impact factor: 4.379

7.  The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma.

Authors:  Jin-Lan Huang; Shun-Wang Cao; Qi-Shui Ou; Bin Yang; Shi-Hao Zheng; Jing Tang; Jing Chen; Yan-Wei Hu; Lei Zheng; Qian Wang
Journal:  Mol Cancer       Date:  2018-05-26       Impact factor: 27.401

8.  The long non-coding RNA AK023948 enhances tumor progression in hepatocellular carcinoma.

Authors:  Bailiang Ye; Bingren Hu; Zhihai Zheng; Ru Zheng; Yixiong Shi
Journal:  Exp Ther Med       Date:  2017-08-24       Impact factor: 2.447

9.  Downregulation of LINC00707 promotes osteogenic differentiation of human bone marrow‑derived mesenchymal stem cells by regulating DKK1 via targeting miR‑103a‑3p.

Authors:  Jun Liu; Minfei Wu; Guang Feng; Rui Li; Yang Wang; Jianhang Jiao
Journal:  Int J Mol Med       Date:  2020-07-09       Impact factor: 4.101

Review 10.  The physiological function of long-noncoding RNAs.

Authors:  He Chen; Ge Shan
Journal:  Noncoding RNA Res       Date:  2020-09-17
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