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Literature DB >> 2159886

Subsensitivity of beta-adrenoceptor responses in asthmatic patients taking regular low dose inhaled salbutamol.

B J Lipworth¹, R A Clark, D P Dhillon, D G McDevitt.

Abstract

Tremor (Tr), chronotropic (HR) and metabolic (K, Glu) responses to cumulative doses of inhaled salbutamol (100 micrograms to 4000 micrograms) were compared in an age and sex matched group of 7 normal (N) and asthmatic (A) subjects. Comparison of regression lines between groups showed differences in HR and K. This was also reflected in attenuation of maximum responses in group A, for HR and K. These results show subsensitivity of chronotropic and hypokalaemic responses in patients with asthma, which may reflect tachyphylaxis from the effects of long term inhaled salbutamol therapy.

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Year: 1990 PMID： 2159886 DOI： 10.1007/BF00265986

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

17 in total

1. Relationship between numbers of beta adrenergic receptors in lymphocytes and disease severity in asthma.

Authors: S M Brooks; K McGowan; I L Bernstein; P Altenau; J Peagler
Journal: J Allergy Clin Immunol Date: 1979-06 Impact factor: 10.793

2. Subsensitivity to the bronchodilator action of albuterol produced by chronic administration.

Authors: H S Nelson; D Raine; H C Doner; W C Posey
Journal: Am Rev Respir Dis Date: 1977-11

3. Beta-adrenergic receptor binding in lymphocytes from patients with asthma.

Authors: K Kariman
Journal: Lung Date: 1980 Impact factor: 2.584

4. Leukocyte cyclic adenosine monophosphate in asthmatic children. Effects of adrenergic therapy.

Authors: H G Morris; S A Rusnak; K Barzens
Journal: Clin Pharmacol Ther Date: 1977-09 Impact factor: 6.875

5. Development of "resistance" in beta-adrenergic receptors of asthmatic patients.

Authors: N L Svedmyr; S A Larsson; G K Thiringer
Journal: Chest Date: 1976-04 Impact factor: 9.410

6. Airway and metabolic responsiveness to intravenous salbutamol in asthma: effect of regular inhaled salbutamol.

Authors: J E Harvey; C J Baldwin; P J Wood; K G Alberti; A E Tattersfield
Journal: Clin Sci (Lond) Date: 1981-05 Impact factor: 6.124

7. Alterations in cyclic adenosine monophosphate metabolism in human bronchial asthma. I. Leukocyte responsiveness to -adrenergic agents.

Authors: C W Parker; J W Smith
Journal: J Clin Invest Date: 1973-01 Impact factor: 14.808

8. The lymphocyte beta-adrenoceptor in normal subjects and patients with bronchial asthma: the effect of different forms of treatment on receptor function.

Authors: M E Conolly; J K Greenacre
Journal: J Clin Invest Date: 1976-12 Impact factor: 14.808

9. Terbutaline-induced desensitization of human lymphocyte beta 2-adrenoceptors. Accelerated restoration of beta-adrenoceptor responsiveness by prednisone and ketotifen.

Authors: O E Brodde; M Brinkmann; R Schemuth; N O'Hara; A Daul
Journal: J Clin Invest Date: 1985-09 Impact factor: 14.808

10. Beta adrenergic receptors of polymorphonuclear particulates in bronchial asthma.

Authors: S P Galant; L Duriseti; S Underwood; S Allred; P A Insel
Journal: J Clin Invest Date: 1980-03 Impact factor: 14.808

11 in total

1. Comparison of the extrapulmonary beta2-adrenoceptor responses and pharmacokinetics of salbutamol given by standard metered dose-inhaler and modified actuator device.

Authors: D M Newnham; D G McDevitt; B J Lipworth
Journal: Br J Clin Pharmacol Date: 1993-11 Impact factor: 4.335

Subsensitivity of beta-adrenoceptor responses in asthmatic patients taking regular low dose inhaled salbutamol.

1. Relationship between numbers of beta adrenergic receptors in lymphocytes and disease severity in asthma.

2. Subsensitivity to the bronchodilator action of albuterol produced by chronic administration.

3. Beta-adrenergic receptor binding in lymphocytes from patients with asthma.

4. Leukocyte cyclic adenosine monophosphate in asthmatic children. Effects of adrenergic therapy.

5. Development of "resistance" in beta-adrenergic receptors of asthmatic patients.

6. Airway and metabolic responsiveness to intravenous salbutamol in asthma: effect of regular inhaled salbutamol.

7. Alterations in cyclic adenosine monophosphate metabolism in human bronchial asthma. I. Leukocyte responsiveness to -adrenergic agents.

8. The lymphocyte beta-adrenoceptor in normal subjects and patients with bronchial asthma: the effect of different forms of treatment on receptor function.

9. Terbutaline-induced desensitization of human lymphocyte beta 2-adrenoceptors. Accelerated restoration of beta-adrenoceptor responsiveness by prednisone and ketotifen.

10. Beta adrenergic receptors of polymorphonuclear particulates in bronchial asthma.

1. Comparison of the extrapulmonary beta2-adrenoceptor responses and pharmacokinetics of salbutamol given by standard metered dose-inhaler and modified actuator device.

2. Dose-response study with high-dose inhaled salmeterol in healthy subjects.

Review 3. Long- versus short-acting beta 2-agonists. Implications for drug therapy.

4. Comparison of the relative airways and systemic potencies of inhaled fenoterol and salbutamol in asthmatic patients.

Review 5. Asthma medications and their potential adverse effects in the elderly: recommendations for prescribing.

6. A population analysis of nebulized (R)-albuterol in dogs using a novel mixed gut-lung absorption PK-PD model.

Review 7. Recovery from bronchoconstriction and bronchodilator tolerance.

8. Regular inhaled beta agonist in asthma: effects on exacerbations and lung function.

Review 9. Risks versus benefits of inhaled beta 2-agonists in the management of asthma.

Review 10. Inhaled beta 2-adrenoceptor agonists in asthma: help or hindrance?