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Literature DB >> 21598008

Oral administration of coenzyme Q₁₀ reduces MPTP-induced loss of dopaminergic nerve terminals in the striatum in mice.

Shota Kobayashi¹, Akiko Muroyama, Hiroaki Matsushima, Ikuo Yoshimura, Yasuhide Mitsumoto.

Abstract

The neuroprotective effect of coenzyme Q(10) (CoQ(10)) has been reported in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. In this study, we investigated whether oral administration of CoQ(10) could protect the striatal dopaminergic (DAergic) nerve terminals against MPTP-induced toxicity in C57BL/6N mice using immunoisolation technique for DAergic synaptosomes. CoQ(10) significantly attenuated decrease in dopamine transporter as well as in synaptophysin and actin protein levels in DAergic synaptosomes from MPTP-treated mice. The effect of CoQ(10) was also observed in crude synaptosomes fraction, but not in homogenate. Our results indicate that the nerve terminals are a site for the action of CoQ(10) against the MPTP-induced DAergic neurodegeneration.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2011 PMID： 21598008 DOI： 10.1007/s10072-011-0627-z

Source DB: PubMed Journal: Neurol Sci ISSN： 1590-1874 Impact factor: 3.307

29 in total

1. Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10.

Authors: M Somayajulu; S McCarthy; M Hung; M Sikorska; H Borowy-Borowski; S Pandey
Journal: Neurobiol Dis Date: 2005-04 Impact factor: 5.996

2. Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's disease.

Authors: N Hattori; M Tanaka; T Ozawa; Y Mizuno
Journal: Ann Neurol Date: 1991-10 Impact factor: 10.422

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Authors: Y Mizuno; S Ohta; M Tanaka; S Takamiya; K Suzuki; T Sato; H Oya; T Ozawa; Y Kagawa
Journal: Biochem Biophys Res Commun Date: 1989-09-29 Impact factor: 3.575

Review 4. The MPTP model of Parkinson's disease.

Authors: Richard Jay Smeyne; Vernice Jackson-Lewis
Journal: Brain Res Mol Brain Res Date: 2005-03-24

5. Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice.

Authors: M F Beal; R T Matthews; A Tieleman; C W Shults
Journal: Brain Res Date: 1998-02-02 Impact factor: 3.252

6. Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease.

Authors: Y Sagot; M Dubois-Dauphin; S A Tan; F de Bilbao; P Aebischer; J C Martinou; A C Kato
Journal: J Neurosci Date: 1995-11 Impact factor: 6.167

7. Neurites undergoing Wallerian degeneration show an apoptotic-like process with Annexin V positive staining and loss of mitochondrial membrane potential.

Authors: Caroline Sievers; Nick Platt; V Hugh Perry; Michael P Coleman; Laura Conforti
Journal: Neurosci Res Date: 2003-06 Impact factor: 3.304

Oral administration of coenzyme Q₁₀ reduces MPTP-induced loss of dopaminergic nerve terminals in the striatum in mice.

1. Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10.

2. Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's disease.

3. Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease.

Review 4. The MPTP model of Parkinson's disease.

5. Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice.

6. Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease.

7. Neurites undergoing Wallerian degeneration show an apoptotic-like process with Annexin V positive staining and loss of mitochondrial membrane potential.

8. Non-apoptotic neurite degeneration in apoptotic neuronal death: pivotal role of mitochondrial function in neurites.

9. Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity.

10. MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology.

Review 1. Pathophysiology and animal modeling of underactive bladder.

Review 2. Coenzyme Q10 and Parkinsonian Syndromes: A Systematic Review.