Literature DB >> 15790530

The MPTP model of Parkinson's disease.

Richard Jay Smeyne1, Vernice Jackson-Lewis.   

Abstract

The biochemical and cellular changes that occur following administration of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) are remarkably similar to that seen in idiopathic Parkinson's disease (PD). In this review, we detail the molecular activities of this compound from peripheral intoxication through its various biotransformations. In addition, we detail the interplay that occurs between the different cellular compartments (neurons and glia) that eventually consort to kill substantia nigra pars compacta (SNpc) neurons.

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Year:  2005        PMID： 15790530     DOI： 10.1016/j.molbrainres.2004.09.017

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  107 in total

1.  Biochemical alterations of the striatum in an MPTP-treated mouse model of Parkinson's disease.

Authors:  Hayato Kuroiwa; Hironori Yokoyama; Hiroki Kimoto; Hiroyuki Kato; Tsutomu Araki
Journal:  Metab Brain Dis       Date:  2010-04-30       Impact factor: 3.584

2.  Exercise protects against MPTP-induced neurotoxicity in mice.

Authors:  Kimberly M Gerecke; Yun Jiao; Amar Pani; Vishwajeeth Pagala; Richard J Smeyne
Journal:  Brain Res       Date:  2010-01-29       Impact factor: 3.252

3.  Supramolecular Inhibition of Neurodegeneration by a Synthetic Receptor.

Authors:  Shengke Li; Huanxian Chen; Xue Yang; David Bardelang; Ian W Wyman; Jianbo Wan; Simon M Y Lee; Ruibing Wang
Journal:  ACS Med Chem Lett       Date:  2015-10-16       Impact factor: 4.345

Review 4.  Essential Dietary Bioactive Lipids in Neuroinflammatory Diseases.

Authors:  Maria Valeria Catani; Valeria Gasperi; Tiziana Bisogno; Mauro Maccarrone
Journal:  Antioxid Redox Signal       Date:  2017-07-24       Impact factor: 8.401

5.  Iron mediates neuritic tree collapse in mesencephalic neurons treated with 1-methyl-4-phenylpyridinium (MPP+).

Authors:  Francisco J Gómez; Pabla Aguirre; Christian Gonzalez-Billault; Marco T Núñez
Journal:  J Neural Transm (Vienna)       Date:  2010-10-02       Impact factor: 3.575

6.  Whole-Transcriptome Analysis of Mouse Models with MPTP-Induced Early Stages of Parkinson's Disease Reveals Stage-Specific Response of Transcriptome and a Possible Role of Myelin-Linked Genes in Neurodegeneration.

Authors:  A Kh Alieva; V S Zyrin; M M Rudenok; A A Kolacheva; M V Shulskaya; M V Ugryumov; P A Slominsky; M I Shadrina
Journal:  Mol Neurobiol       Date:  2018-02-03       Impact factor: 5.590

7.  MPP(+) -dependent inhibition of Ih reduces spontaneous activity and enhances EPSP summation in nigral dopamine neurons.

Authors:  A Masi; R Narducci; E Landucci; F Moroni; G Mannaioni
Journal:  Br J Pharmacol       Date:  2013-05       Impact factor: 8.739

Review 8.  Parkinson's disease and enhanced inflammatory response.

Authors:  Iva Stojkovska; Brandon M Wagner; Brad E Morrison
Journal:  Exp Biol Med (Maywood)       Date:  2015-03-13

9.  Tauroursodeoxycholic Acid Protects Against Mitochondrial Dysfunction and Cell Death via Mitophagy in Human Neuroblastoma Cells.

Authors:  Inês Fonseca; Gisela Gordino; Sara Moreira; Maria João Nunes; Carla Azevedo; Maria João Gama; Elsa Rodrigues; Cecília Maria Pereira Rodrigues; Margarida Castro-Caldas
Journal:  Mol Neurobiol       Date:  2016-10-03       Impact factor: 5.590

10.  Cholinergic and Dopaminergic Alterations in Nigrostriatal Neurons Are Involved in Environmental Enrichment Motor Protection in a Mouse Model of Parkinson's Disease.

Authors:  Willyan Franco Hilario; Alice Laschuk Herlinger; Lorena Bianchine Areal; Lívia Silveira de Moraes; Tamara Andrea Alarcon Ferreira; Tassiane Emanuelle Servane Andrade; Cristina Martins-Silva; Rita Gomes Wanderley Pires
Journal:  J Mol Neurosci       Date:  2016-09-22       Impact factor: 3.444
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