Literature DB >> 21597456

Emergency department visits after use of a drug sold as "bath salts"--Michigan, November 13, 2010-March 31, 2011.

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Abstract

On February 1, 2011, in response to multiple news reports, the Michigan Department of Community Health (MDCH) contacted the Children's Hospital of Michigan Poison Control Center (PCC) regarding any reports of illness in the state caused by the use of recreational designer drugs sold as "bath salts." Unlike traditional cosmetic bath salts, which are packaged and sold for adding to bath water for soaking and cleaning, the drugs sold as "bath salts" have no legitimate use for bathing and are intended for substance abuse. These products can contain stimulant compounds such as 3,4-methylenedioxypyrovalerone (MDPV) or 4-methylmethcathinone (mephedrone). The PCC told MDCH that, earlier in the day, the PCC had learned that numerous persons had visited the local emergency department (ED) in Marquette County with cardiovascular and neurologic signs of acute intoxication. This report summarizes the subsequent investigation, which identified 35 persons who had ingested, inhaled, or injected "bath salts" and visited a Michigan ED during November 13, 2010-March 31, 2011. Among the 35 patients, the most common signs and symptoms of toxicity were agitation (23 patients [66%]), tachycardia (22 [63%]), and delusions/hallucinations (14 [40%]). Seventeen patients were hospitalized, and one was dead upon arrival at the ED. The coordinated efforts of public health agencies, health-care providers, poison control centers, and law enforcement agencies enabled rapid identification of this emerging health problem. Mitigation of the problem required the execution of an emergency public health order to remove the toxic "bath salts" from the marketplace. Lessons from the Michigan experience could have relevance to other areas of the United States experiencing similar problems.

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Year:  2011        PMID: 21597456

Source DB:  PubMed          Journal:  MMWR Morb Mortal Wkly Rep        ISSN: 0149-2195            Impact factor:   17.586


  33 in total

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Journal:  J Med Toxicol       Date:  2012-03

2.  The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue.

Authors:  Michael H Baumann; Mario A Ayestas; John S Partilla; Jacqueline R Sink; Alexander T Shulgin; Paul F Daley; Simon D Brandt; Richard B Rothman; Arnold E Ruoho; Nicholas V Cozzi
Journal:  Neuropsychopharmacology       Date:  2011-12-14       Impact factor: 7.853

Review 3.  Here today, gone tomorrow…and back again? A review of herbal marijuana alternatives (K2, Spice), synthetic cathinones (bath salts), kratom, Salvia divinorum, methoxetamine, and piperazines.

Authors:  Christopher D Rosenbaum; Stephanie P Carreiro; Kavita M Babu
Journal:  J Med Toxicol       Date:  2012-03

4.  Death following recreational use of designer drug "bath salts" containing 3,4-Methylenedioxypyrovalerone (MDPV).

Authors:  Brittany L Murray; Christine M Murphy; Michael C Beuhler
Journal:  J Med Toxicol       Date:  2012-03

5.  "Bath salts"-induced psychosis in a young woman.

Authors:  Sadaf Khan; Farhat Shaheen; Hina Sarwar; Jules Molina; Saira Mushtaq
Journal:  Prim Care Companion CNS Disord       Date:  2013

6.  Intoxications associated with agitation, tachycardia, hypertension, and Fever: differential diagnosis, evaluation, and management.

Authors:  Christopher J Keary; Shamim H Nejad; J J Rasimas; Theodore A Stern
Journal:  Prim Care Companion CNS Disord       Date:  2013-05-16

Review 7.  Baths salts, spice, and related designer drugs: the science behind the headlines.

Authors:  Michael H Baumann; Ernesto Solis; Lucas R Watterson; Julie A Marusich; William E Fantegrossi; Jenny L Wiley
Journal:  J Neurosci       Date:  2014-11-12       Impact factor: 6.167

8.  Binge-like acquisition of 3,4-methylenedioxypyrovalerone (MDPV) self-administration and wheel activity in rats.

Authors:  S M Aarde; P K Huang; T J Dickerson; M A Taffe
Journal:  Psychopharmacology (Berl)       Date:  2014-11-26       Impact factor: 4.530

9.  Contribution of monoaminergic mechanisms to the discriminative stimulus effects of 3,4-methylenedioxypyrovalerone (MDPV) in Sprague-Dawley rats.

Authors:  Harmony I Risca; Lisa E Baker
Journal:  Psychopharmacology (Berl)       Date:  2018-12-15       Impact factor: 4.530

10.  Binge-like acquisition of α-pyrrolidinopentiophenone (α-PVP) self-administration in female rats.

Authors:  Mehrak Javadi-Paydar; Eric L Harvey; Yanabel Grant; Sophia A Vandewater; Kevin M Creehan; Jacques D Nguyen; Tobin J Dickerson; Michael A Taffe
Journal:  Psychopharmacology (Berl)       Date:  2018-06-16       Impact factor: 4.530

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