| Literature DB >> 2159551 |
Abstract
It has been documented that the activity of a specific promoter can be occluded by the presence of another promoter element upstream. We present evidence for a phenomenon contradictory to that predicted by the promoter occlusion theory. Transcription from the hamster aprt (adenine phosphoribosyltransferase) promoter was augmented instead of repressed in transfected mouse L cells when an upstream Moloney murine sarcoma virus enhancer-promoter element was induced with butyrate. Without an adjacent Moloney murine sarcoma virus element, butyrate could not activate the aprt promoter.Entities:
Mesh:
Substances:
Year: 1990 PMID: 2159551 PMCID: PMC249474 DOI: 10.1128/JVI.64.6.2907-2911.1990
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103