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Literature DB >> 21593399

Regulatory T cells: customizing for the clinic.

Abstract

Immune-suppressive cellular immunotherapy requires large numbers of antigen-specific regulatory T cells (T(reg) cells), lymphocytes that suppress certain immune responses. Together, three papers in this issue of Science Translational Medicine describe protocols for the ex vivo expansion of human T(reg) cells and assess the immune-suppressive function of ex vivo-manipulated T(reg) cells after transfer into humanized mouse disease models. Along with recent phase I clinical trial results, these new data provide a platform for clinical use of T(reg) cells as personalized therapeutic agents for the treatment of autoimmune diseases, graft-versus-host disease, and transplant rejection.

Entities: Disease Species

Mesh：

Year: 2011 PMID： 21593399 DOI： 10.1126/scitranslmed.3001819

Source DB: PubMed Journal: Sci Transl Med ISSN： 1946-6234 Impact factor: 17.956

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Cited

15 in total

1. Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation.

Authors: Kazuyuki Murase; Haesook T Kim; O R Gregory Bascug; Yutaka Kawano; Jeremy Ryan; Ken-ichi Matsuoka; Matthew S Davids; John Koreth; Vincent T Ho; Corey Cutler; Philippe Armand; Edwin P Alyea; Bruce R Blazar; Joseph H Antin; Robert J Soiffer; Anthony Letai; Jerome Ritz
Journal: Haematologica Date: 2014-05-23 Impact factor: 9.941

2. Robust and cost effective expansion of human regulatory T cells highly functional in a xenograft model of graft-versus-host disease.

Authors: Rikhia Chakraborty; Aruna Mahendravada; Serena K Perna; Cliona M Rooney; Helen E Heslop; Juan F Vera; Barbara Savoldo; Gianpietro Dotti
Journal: Haematologica Date: 2012-12-14 Impact factor: 9.941

Review 3. FOXP3+ regulatory T cells and their functional regulation.

Authors: Zhiyuan Li; Dan Li; Andy Tsun; Bin Li
Journal: Cell Mol Immunol Date: 2015-02-16 Impact factor: 11.530

4. Low-Dose IL-2 Therapy in Transplantation, Autoimmunity, and Inflammatory Diseases.

Authors: Maryam Tahvildari; Reza Dana
Journal: J Immunol Date: 2019-12-01 Impact factor: 5.422

5. Interleukin-2 and regulatory T cells in graft-versus-host disease.

Authors: John Koreth; Ken-ichi Matsuoka; Haesook T Kim; Sean M McDonough; Bhavjot Bindra; Edwin P Alyea; Philippe Armand; Corey Cutler; Vincent T Ho; Nathaniel S Treister; Don C Bienfang; Sashank Prasad; Dmitrios Tzachanis; Robin M Joyce; David E Avigan; Joseph H Antin; Jerome Ritz; Robert J Soiffer
Journal: N Engl J Med Date: 2011-12-01 Impact factor: 91.245

Regulatory T cells: customizing for the clinic.

1. Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation.

2. Robust and cost effective expansion of human regulatory T cells highly functional in a xenograft model of graft-versus-host disease.

Review 3. FOXP3+ regulatory T cells and their functional regulation.

4. Low-Dose IL-2 Therapy in Transplantation, Autoimmunity, and Inflammatory Diseases.

5. Interleukin-2 and regulatory T cells in graft-versus-host disease.

Review 6. Clinical perspectives for regulatory T cells in transplantation tolerance.

Review 7. Natural killer cells and regulatory T cells: how to manipulate a graft for optimal GVL.

8. Site-specific accumulation of recently activated CD4+ Foxp3+ regulatory T cells following adoptive transfer.

Review 9. Living donor liver transplantation: where do we stand and where are we going?

10. Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cells.