2-Amino-1-methyl-1H-imidazol-4(5H)-one dimethyl sulfoxide monosolvate.

In the title compound, C(4)H(7)N(3)O·C(2)H(6)OS, creatinine [2-amino-1-methyl-1H-imidazol-4(5H)one] exists in the amine form. The ring is planar (r.m.s. deviation for all non-H atoms = 0.017 Å). In the crystal, two creatinine mol-ecules form centrosymmetric hydrogen-bonded dimers linked by pairs of N-H⋯N hydrogen bonds. In addition, creatinine is linked to a dimethyl sulfoxide mol-ecule by an N-H⋯O inter-action. The packing shows layers parallel to (120).

Related literature

For information about creatinine, see: Narayanan & Appleton (1980 ▶). For related structures, see: Bell et al. (1995 ▶). For co-crystallization experiments, see: Ton & Bolte (2009 ▶). For hydrogen-bond patterns, see: Bernstein et al. (1995 ▶).

Experimental

Crystal data

C4H7N3O·C2H6OS

M = 191.25

Triclinic,

a = 5.8997 (10) Å

b = 7.3018 (13) Å

c = 11.276 (2) Å

α = 75.861 (18)°

β = 83.763 (16)°

γ = 79.694 (13)°

V = 462.36 (14) Å3

Z = 2

Mo Kα radiation

μ = 0.32 mm−1

T = 173 K

0.50 × 0.40 × 0.40 mm

Data collection

Siemens SMART 1K CCD diffractometer

8161 measured reflections

2997 independent reflections

2597 reflections with I > 2σ(I)

R int = 0.022

Refinement

R[F 2 > 2σ(F 2)] = 0.031

wR(F 2) = 0.082

S = 0.98

2997 reflections

120 parameters

H atoms treated by a mixture of independent and constrained refinement

Δρmax = 0.29 e Å−3

Δρmin = −0.32 e Å−3

Data collection: SMART (Siemens, 1995 ▶); cell refinement: SAINT (Siemens, 1995 ▶); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: Mercury (Macrae et al., 2008 ▶) and XP (Sheldrick, 2008 ▶); software used to prepare material for publication: publCIF (Westrip, 2010 ▶).

Crystal structure: contains datablocks I, global. DOI: 10.1107/S1600536810038997/bx2310sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536810038997/bx2310Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

C4H7N3O·C2H6OS	Z = 2
Mr = 191.25	F(000) = 204
Triclinic, P1	Dx = 1.374 Mg m−3
Hall symbol: -P 1	Mo Kα radiation, λ = 0.71073 Å
a = 5.8997 (10) Å	Cell parameters from 131 reflections
b = 7.3018 (13) Å	θ = 1.9–32.6°
c = 11.276 (2) Å	µ = 0.32 mm−1
α = 75.861 (18)°	T = 173 K
β = 83.763 (16)°	Block, colorless
γ = 79.694 (13)°	0.50 × 0.40 × 0.40 mm
V = 462.36 (14) Å3

Siemens SMART 1K CCD diffractometer	2597 reflections with I > 2σ(I)
Radiation source: normal-focus sealed tube	Rint = 0.022
graphite	θmax = 32.6°, θmin = 1.9°
ω scans	h = −8→8
8161 measured reflections	k = −10→10
2997 independent reflections	l = −16→16

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.031	Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.082	H atoms treated by a mixture of independent and constrained refinement
S = 0.98	w = 1/[σ2(Fo2) + (0.0417P)2 + 0.166P] where P = (Fo2 + 2Fc2)/3
2997 reflections	(Δ/σ)max = 0.001
120 parameters	Δρmax = 0.29 e Å−3
0 restraints	Δρmin = −0.32 e Å−3

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

	x	y	z	Uiso*/Ueq
N1	0.82954 (15)	0.63634 (13)	0.38132 (8)	0.01974 (17)
C2	0.72822 (18)	0.72352 (15)	0.27441 (9)	0.01971 (19)
C3	0.48598 (18)	0.82480 (16)	0.30299 (9)	0.0218 (2)
H3A	0.4687	0.9638	0.2660	0.026*
H3B	0.3661	0.7699	0.2743	0.026*
N4	0.47636 (15)	0.78571 (13)	0.43582 (8)	0.02055 (18)
C5	0.67429 (17)	0.67487 (14)	0.47372 (9)	0.01701 (18)
O21	0.81565 (15)	0.72319 (13)	0.17026 (7)	0.02772 (18)
C41	0.27148 (18)	0.84273 (17)	0.50969 (11)	0.0239 (2)
H41A	0.1484	0.7740	0.5006	0.036*
H41B	0.2206	0.9807	0.4824	0.036*
H41C	0.3068	0.8120	0.5959	0.036*
N51	0.72130 (16)	0.60912 (14)	0.59037 (8)	0.02144 (18)
H51A	0.630 (3)	0.632 (2)	0.6476 (16)	0.038 (4)*
H51B	0.856 (3)	0.534 (2)	0.6059 (14)	0.029 (4)*
O1D	0.45535 (15)	0.70620 (14)	0.79813 (8)	0.0308 (2)
S2D	0.29265 (4)	0.65071 (4)	0.90915 (2)	0.02067 (8)
C3D	0.3041 (2)	0.81135 (17)	1.00396 (10)	0.0247 (2)
H3D1	0.4563	0.7846	1.0372	0.037*
H3D2	0.1847	0.7944	1.0715	0.037*
H3D3	0.2775	0.9433	0.9552	0.037*
C4D	0.0081 (2)	0.7428 (2)	0.86076 (12)	0.0327 (3)
H4D1	−0.0012	0.8787	0.8203	0.049*
H4D2	−0.1033	0.7278	0.9322	0.049*
H4D3	−0.0275	0.6725	0.8032	0.049*

	U11	U22	U33	U12	U13	U23
N1	0.0168 (4)	0.0224 (4)	0.0181 (4)	0.0009 (3)	−0.0003 (3)	−0.0043 (3)
C2	0.0190 (5)	0.0190 (5)	0.0200 (4)	−0.0022 (4)	−0.0009 (3)	−0.0031 (4)
C3	0.0190 (5)	0.0246 (5)	0.0195 (4)	0.0001 (4)	−0.0031 (4)	−0.0025 (4)
N4	0.0145 (4)	0.0256 (4)	0.0195 (4)	0.0024 (3)	−0.0013 (3)	−0.0052 (3)
C5	0.0148 (4)	0.0162 (4)	0.0202 (4)	−0.0018 (3)	−0.0013 (3)	−0.0049 (3)
O21	0.0282 (4)	0.0329 (4)	0.0189 (4)	−0.0009 (3)	0.0024 (3)	−0.0044 (3)
C41	0.0148 (4)	0.0272 (5)	0.0284 (5)	0.0016 (4)	0.0016 (4)	−0.0088 (4)
N51	0.0173 (4)	0.0274 (5)	0.0173 (4)	0.0033 (3)	−0.0008 (3)	−0.0059 (3)
O1D	0.0254 (4)	0.0441 (5)	0.0239 (4)	−0.0052 (4)	0.0076 (3)	−0.0141 (4)
S2D	0.01945 (13)	0.02222 (13)	0.02000 (12)	−0.00115 (9)	−0.00068 (9)	−0.00608 (9)
C3D	0.0250 (5)	0.0292 (5)	0.0210 (5)	−0.0033 (4)	0.0003 (4)	−0.0096 (4)
C4D	0.0202 (5)	0.0450 (7)	0.0337 (6)	−0.0024 (5)	−0.0056 (4)	−0.0110 (5)

N1—C5	1.3591 (13)	C41—H41C	0.9800
N1—C2	1.3644 (13)	N51—H51A	0.823 (18)
C2—O21	1.2306 (13)	N51—H51B	0.887 (16)
C2—C3	1.5269 (15)	O1D—S2D	1.5109 (9)
C3—N4	1.4514 (14)	S2D—C3D	1.7833 (12)
C3—H3A	0.9900	S2D—C4D	1.7844 (13)
C3—H3B	0.9900	C3D—H3D1	0.9800
N4—C5	1.3426 (13)	C3D—H3D2	0.9800
N4—C41	1.4487 (13)	C3D—H3D3	0.9800
C5—N51	1.3269 (13)	C4D—H4D1	0.9800
C41—H41A	0.9800	C4D—H4D2	0.9800
C41—H41B	0.9800	C4D—H4D3	0.9800
C5—N1—C2	106.69 (8)	H41A—C41—H41C	109.5
O21—C2—N1	126.20 (10)	H41B—C41—H41C	109.5
O21—C2—C3	124.36 (10)	C5—N51—H51A	123.0 (12)
N1—C2—C3	109.44 (9)	C5—N51—H51B	117.3 (10)
N4—C3—C2	101.23 (8)	H51A—N51—H51B	119.7 (16)
N4—C3—H3A	111.5	O1D—S2D—C3D	106.00 (6)
C2—C3—H3A	111.5	O1D—S2D—C4D	106.16 (6)
N4—C3—H3B	111.5	C3D—S2D—C4D	97.79 (6)
C2—C3—H3B	111.5	S2D—C3D—H3D1	109.5
H3A—C3—H3B	109.3	S2D—C3D—H3D2	109.5
C5—N4—C41	128.18 (9)	H3D1—C3D—H3D2	109.5
C5—N4—C3	108.39 (8)	S2D—C3D—H3D3	109.5
C41—N4—C3	123.06 (9)	H3D1—C3D—H3D3	109.5
N51—C5—N4	124.29 (10)	H3D2—C3D—H3D3	109.5
N51—C5—N1	121.51 (9)	S2D—C4D—H4D1	109.5
N4—C5—N1	114.19 (9)	S2D—C4D—H4D2	109.5
N4—C41—H41A	109.5	H4D1—C4D—H4D2	109.5
N4—C41—H41B	109.5	S2D—C4D—H4D3	109.5
H41A—C41—H41B	109.5	H4D1—C4D—H4D3	109.5
N4—C41—H41C	109.5	H4D2—C4D—H4D3	109.5
C5—N1—C2—O21	179.20 (11)	C41—N4—C5—N51	−5.49 (18)
C5—N1—C2—C3	−0.46 (12)	C3—N4—C5—N51	−178.65 (10)
O21—C2—C3—N4	−177.89 (11)	C41—N4—C5—N1	175.64 (10)
N1—C2—C3—N4	1.78 (11)	C3—N4—C5—N1	2.48 (13)
C2—C3—N4—C5	−2.45 (11)	C2—N1—C5—N51	179.85 (10)
C2—C3—N4—C41	−176.03 (10)	C2—N1—C5—N4	−1.25 (12)

D—H···A	D—H	H···A	D···A	D—H···A
N51—H51A···O1D	0.823 (18)	2.028 (18)	2.8403 (13)	169.3 (17)
N51—H51B···N1i	0.887 (16)	2.040 (16)	2.9225 (14)	172.9 (14)

Table 1

Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
N51—H51A⋯O1D	0.823 (18)	2.028 (18)	2.8403 (13)	169.3 (17)
N51—H51B⋯N1i	0.887 (16)	2.040 (16)	2.9225 (14)	172.9 (14)

Symmetry code: (i) .