Literature DB >> 21587290

Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates.

Timothy J Collier1, Nicholas M Kanaan, Jeffrey H Kordower.   

Abstract

Ageing is the greatest risk factor for the development of Parkinson's disease. However, the current dogma holds that cellular mechanisms that are associated with ageing of midbrain dopamine neurons and those that are related to dopamine neuron degeneration in Parkinson's disease are unrelated. We propose, based on evidence from studies of non-human primates, that normal ageing and the degeneration of dopamine neurons in Parkinson's disease are linked by the same cellular mechanisms and, therefore, that markers of cellular risk factors accumulate with age in a pattern that mimics the pattern of degeneration observed in Parkinson's disease. We contend that ageing induces a pre-parkinsonian state, and that the cellular mechanisms of dopamine neuron demise during normal ageing are accelerated or exaggerated in Parkinson's disease through a combination of genetic and environmental factors.

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Year:  2011        PMID： 21587290      PMCID： PMC3387674          DOI： 10.1038/nrn3039

Source DB:  PubMed          Journal:  Nat Rev Neurosci        ISSN： 1471-003X            Impact factor:   34.870


  121 in total

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Authors:  Masato Asanuma; Ikuko Miyazaki; Francisco J Diaz-Corrales; Norio Ogawa
Journal:  Acta Med Okayama       Date:  2004-10       Impact factor: 0.892

2.  Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection.

Authors:  Chee Yeun Chung; Hyemyung Seo; Kai Christian Sonntag; Andrew Brooks; Ling Lin; Ole Isacson
Journal:  Hum Mol Genet       Date:  2005-05-11       Impact factor: 6.150

3.  Absence of age-related changes in nigral dopaminergic neurons of Asian Indians: relevance to lower incidence of Parkinson's disease.

Authors:  P A Alladi; A Mahadevan; T C Yasha; T R Raju; S K Shankar; U Muthane
Journal:  Neuroscience       Date:  2008-12-13       Impact factor: 3.590

4.  Age-related changes in dopamine transporters and accumulation of 3-nitrotyrosine in rhesus monkey midbrain dopamine neurons: relevance in selective neuronal vulnerability to degeneration.

Authors:  N M Kanaan; J H Kordower; T J Collier
Journal:  Eur J Neurosci       Date:  2008-06       Impact factor: 3.386

5.  K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons.

Authors:  Birgit Liss; Olga Haeckel; Johannes Wildmann; Takashi Miki; Susumu Seino; Jochen Roeper
Journal:  Nat Neurosci       Date:  2005-11-20       Impact factor: 24.884

6.  Selective vulnerability of dopaminergic neurons to microtubule depolymerization.

Authors:  Yong Ren; Wenhua Liu; Houbo Jiang; Qian Jiang; Jian Feng
Journal:  J Biol Chem       Date:  2005-08-09       Impact factor: 5.157

7.  Gene expression profiling of rat midbrain dopamine neurons: implications for selective vulnerability in parkinsonism.

Authors:  James G Greene; Raymond Dingledine; J Timothy Greenamyre
Journal:  Neurobiol Dis       Date:  2005-02       Impact factor: 5.996

8.  Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons.

Authors:  Eugene V Mosharov; Kristin E Larsen; Ellen Kanter; Kester A Phillips; Krystal Wilson; Yvonne Schmitz; David E Krantz; Kazuto Kobayashi; Robert H Edwards; David Sulzer
Journal:  Neuron       Date:  2009-04-30       Impact factor: 17.173

9.  Genomic investigation of alpha-synuclein multiplication and parkinsonism.

Authors:  Owen A Ross; Adam T Braithwaite; Lisa M Skipper; Jennifer Kachergus; Mary M Hulihan; Frank A Middleton; Kenya Nishioka; Julia Fuchs; Thomas Gasser; Demetrius M Maraganore; Charles H Adler; Lydie Larvor; Marie-Christine Chartier-Harlin; Christer Nilsson; J William Langston; Katrina Gwinn; Nobutaka Hattori; Matthew J Farrer
Journal:  Ann Neurol       Date:  2008-06       Impact factor: 10.422

10.  Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in monkeys.

Authors:  Nicholas M Kanaan; Jeffrey H Kordower; Timothy J Collier
Journal:  Glia       Date:  2008-08-15       Impact factor: 7.452
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  138 in total

1.  Testing NF-κB-based therapy in hemiparkinsonian monkeys.

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Journal:  J Neuroimmune Pharmacol       Date:  2012-06-03       Impact factor: 4.147

Review 2.  Gene-environment interactions in Parkinson's disease: specific evidence in humans and mammalian models.

Authors:  Jason R Cannon; J Timothy Greenamyre
Journal:  Neurobiol Dis       Date:  2012-07-07       Impact factor: 5.996

3.  The changing tree in Parkinson's disease.

Authors:  Paolo Calabresi; Massimiliano Di Filippo
Journal:  Nat Neurosci       Date:  2015-09       Impact factor: 24.884

Review 4.  Understanding Parkinson's Disease through the Use of Cell Reprogramming.

Authors:  Rebecca Playne; Bronwen Connor
Journal:  Stem Cell Rev Rep       Date:  2017-04       Impact factor: 5.739

Review 5.  The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease.

Authors:  D J Surmeier; J N Guzman; J Sanchez-Padilla; P T Schumacker
Journal:  Neuroscience       Date:  2011-08-25       Impact factor: 3.590

6.  Recombinant adenoassociated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain.

Authors:  Nicole K Polinski; Sara E Gombash; Fredric P Manfredsson; Jack W Lipton; Christopher J Kemp; Allyson Cole-Strauss; Nicholas M Kanaan; Kathy Steece-Collier; Nathan C Kuhn; Susan L Wohlgenant; Caryl E Sortwell
Journal:  Neurobiol Aging       Date:  2014-10-13       Impact factor: 4.673

7.  Age-related Brain Metabolic Changes up to Seventh Decade in Healthy Humans : Whole-brain Magnetic Resonance Spectroscopic Imaging Study.

Authors:  Helen Maghsudi; Martin Schütze; Andrew A Maudsley; Mete Dadak; Heinrich Lanfermann; Xiao-Qi Ding
Journal:  Clin Neuroradiol       Date:  2019-07-26       Impact factor: 3.649

Review 8.  Selective neuronal vulnerability in Parkinson disease.

Authors:  D James Surmeier; José A Obeso; Glenda M Halliday
Journal:  Nat Rev Neurosci       Date:  2017-01-20       Impact factor: 34.870

Review 9.  α-Synuclein oligomers and clinical implications for Parkinson disease.

Authors:  Lorraine V Kalia; Suneil K Kalia; Pamela J McLean; Andres M Lozano; Anthony E Lang
Journal:  Ann Neurol       Date:  2012-12-07       Impact factor: 10.422

Review 10.  Aging with HIV-1 Infection: Motor Functions, Cognition, and Attention--A Comparison with Parkinson's Disease.

Authors:  S DeVaughn; E M Müller-Oehring; B Markey; H M Brontë-Stewart; T Schulte
Journal:  Neuropsychol Rev       Date:  2015-11-17       Impact factor: 7.444
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