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Literature DB >> 2158619

Nifedipine impairs neutrophil respiratory burst by a mechanism other than calcium channel blockade.

K Nalini¹, K I Andrabi, N K Ganguly, P L Wahi.

Abstract

Superoxide production by mice neutrophils was inhibited by nifedipine exposure in a dose dependent manner. The inhibition of Ca2+ uptake elicited by nifedipine did not appear to account for the observed effect as the extracellular Ca2+ enrichment and depletion did not produce a significant reversal of the inhibition. Cytosolic free Ca2+ as measured by Quin 2AM fluorescence did not show any significant change, indicating that the effect was independent of the inhibition of Ca2+ influx. In addition nifedipine caused a significant inhibition (p less than 0.01) in NADPH oxidase activity. Our data indicates that nifedipine inhibits superoxide production independent of inhibiting Ca2+ inflow and supports the hypothesis that Ca2+ antagonists affect cellular functions by non Ca2+ mediated process as well.

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Year: 1990 PMID： 2158619 DOI： 10.1007/BF00223489

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

32 in total

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Authors: R A Janis; A Scriabine
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Authors: J G Elferink
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3 in total