OBJECTIVE: The objective of the present study was to evaluate the effects of drinking 2 additional litres of water/day on several urinary risk factors for lithiasis in healthy subjects, through measurement of crystallization risk indices (Tiselius CRI). MATERIALS AND METHODS:48 healthy subjects, aged 25 to 50 were studied for urinary parameters including CRI in the laboratory ward, for 24 hours. After this first period, they were randomized either to a 2L/d additional water intake (treated group) or usual fluid consumption (control group) for a 6 days period, which ended by a second measurement period in the laboratory ward for 24 hours. RESULTS:Total additional water intake was actually 1.3L/d on average in treated subjects, because subjects decreased other usual sources of fluid intake. In 24 hour urine, Tiselius CRI varied differently among treated subjects and controls between the 2 periods; male controls subjects experienced much higher values (above 2 in average in first morning urine sample) in the second period (p = 0.05). Of interest, in a transversal analysis, we observed a positive relation between BMI or waist circumference on the one hand, and with 24 hour urea excretion or osmotic load on the other hand. CONCLUSION: These results show a beneficial effect of a final 1.3L additional water intake on Tiselius CRI in healthy subjects.
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OBJECTIVE: The objective of the present study was to evaluate the effects of drinking 2 additional litres of water/day on several urinary risk factors for lithiasis in healthy subjects, through measurement of crystallization risk indices (Tiselius CRI). MATERIALS AND METHODS: 48 healthy subjects, aged 25 to 50 were studied for urinary parameters including CRI in the laboratory ward, for 24 hours. After this first period, they were randomized either to a 2L/d additional water intake (treated group) or usual fluid consumption (control group) for a 6 days period, which ended by a second measurement period in the laboratory ward for 24 hours. RESULTS: Total additional water intake was actually 1.3L/d on average in treated subjects, because subjects decreased other usual sources of fluid intake. In 24 hour urine, Tiselius CRI varied differently among treated subjects and controls between the 2 periods; male controls subjects experienced much higher values (above 2 in average in first morning urine sample) in the second period (p = 0.05). Of interest, in a transversal analysis, we observed a positive relation between BMI or waist circumference on the one hand, and with 24 hour urea excretion or osmotic load on the other hand. CONCLUSION: These results show a beneficial effect of a final 1.3L additional water intake on Tiselius CRI in healthy subjects.
Authors: Erica T Perrier; Inmaculada Buendia-Jimenez; Mariacristina Vecchio; Lawrence E Armstrong; Ivan Tack; Alexis Klein Journal: Dis Markers Date: 2015-03-18 Impact factor: 3.434
Authors: Erica T Perrier; Lawrence E Armstrong; Michel Daudon; Stavros Kavouras; Max Lafontan; Florian Lang; François Péronnet; Jodi D Stookey; Ivan Tack; Alexis Klein Journal: Obes Facts Date: 2014-04-04 Impact factor: 3.942
Authors: Laura Walawender; Jeremy Patterson; Robert Strouse; John Ketz; Vijay Saxena; Emily Alexy; Andrew Schwaderer Journal: Front Pediatr Date: 2018-06-06 Impact factor: 3.418