Literature DB >> 2158445

Cooperation between bovine leukaemia virus transactivator protein and Ha-ras oncogene product in cellular transformation.

L Willems1, H Heremans, G Chen, D Portetelle, A Billiau, A Burny, R Kettmann.   

Abstract

Human T-lymphotropic viruses (HTLV-I and -II) and bovine leukaemia virus (BLV) express transactivator proteins able to increase long terminal repeat (LTR) directed viral expression. These transacting factors are though to be involved in the induction of leukaemia by these viruses. Transfection of BLV transactivator p34tax together with Ha-ras immortalizes and transforms rat embryo fibroblasts, in vitro. The transformed cell induce tumours in nude mice. These data emphasize the causal role exerted by p34tax in in vivo tumorigenesis.

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Year:  1990        PMID： 2158445      PMCID： PMC551852          DOI： 10.1002/j.1460-2075.1990.tb08277.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  31 in total

1.  Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.

Authors:  H Land; L F Parada; R A Weinberg
Journal:  Nature       Date:  1983 Aug 18-24       Impact factor: 49.962

2.  Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture.

Authors:  H E Ruley
Journal:  Nature       Date:  1983 Aug 18-24       Impact factor: 49.962

3.  Functional activation of the long terminal repeat of human T-cell leukemia virus type I by a trans-acting factor.

Authors:  J Fujisawa; M Seiki; T Kiyokawa; M Yoshida
Journal:  Proc Natl Acad Sci U S A       Date:  1985-04       Impact factor: 11.205

4.  Trans activation of the bovine leukemia virus long terminal repeat in BLV-infected cells.

Authors:  C A Rosen; J G Sodroski; R Kettman; A Burny; W A Haseltine
Journal:  Science       Date:  1985-01-18       Impact factor: 47.728

5.  Role of the 3' long open reading frame region of bovine leukemia virus in the maintenance of cell transformation.

Authors:  R Kettmann; Y Cleuter; D Gregoire; A Burny
Journal:  J Virol       Date:  1985-06       Impact factor: 5.103

6.  Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53.

Authors:  J R Jenkins; K Rudge; G A Currie
Journal:  Nature       Date:  1984 Dec 13-19       Impact factor: 49.962

7.  A transcriptional activator protein encoded by the x-lor region of the human T-cell leukemia virus.

Authors:  J Sodroski; C Rosen; W C Goh; W Haseltine
Journal:  Science       Date:  1985-06-21       Impact factor: 47.728

8.  Location of cis-acting regulatory sequences in the human T-cell leukemia virus type I long terminal repeat.

Authors:  C A Rosen; J G Sodroski; W A Haseltine
Journal:  Proc Natl Acad Sci U S A       Date:  1985-10       Impact factor: 11.205

9.  Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation.

Authors:  L F Parada; H Land; R A Weinberg; D Wolf; V Rotter
Journal:  Nature       Date:  1984 Dec 13-19       Impact factor: 49.962

10.  Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1.

Authors:  J Inoue; M Seiki; T Taniguchi; S Tsuru; M Yoshida
Journal:  EMBO J       Date:  1986-11       Impact factor: 11.598
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  35 in total

1.  Assessment of bovine leukemia virus transcripts in vivo.

Authors:  J Rovnak; J W Casey
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

2.  Discordance between bovine leukemia virus tax immortalization in vitro and oncogenicity in vivo.

Authors:  J C Twizere; P Kerkhofs; A Burny; D Portetelle; R Kettmann; L Willems
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

3.  Mutations in the bovine leukemia virus Tax protein can abrogate the long terminal repeat-directed transactivating activity without concomitant loss of transforming potential.

Authors:  L Willems; C Grimonpont; H Heremans; N Rebeyrotte; G Chen; D Portetelle; A Burny; R Kettmann
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

4.  Insights into gene expression changes impacting B-cell transformation: cross-species microarray analysis of bovine leukemia virus tax-responsive genes in ovine B cells.

Authors:  Pavel Klener; Maud Szynal; Yvette Cleuter; Makram Merimi; Hugues Duvillier; Françoise Lallemand; Claude Bagnis; Philip Griebel; Christos Sotiriou; Arsène Burny; Philippe Martiat; Anne Van den Broeke
Journal:  J Virol       Date:  2006-02       Impact factor: 5.103

5.  Bovine leukemia virus-induced lymphocytosis and increased cell survival mainly involve the CD11b+ B-lymphocyte subset in sheep.

Authors:  N Chevallier; M Berthelemy; D Le Rhun; V Lainé; D Levy; I Schwartz-Cornil
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

6.  Detection of a novel bovine lymphotropic herpesvirus.

Authors:  J Rovnak; S L Quackenbush; R A Reyes; J D Baines; C R Parrish; J W Casey
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

7.  CD154 costimulated ovine primary B cells, a cell culture system that supports productive infection by bovine leukemia virus.

Authors:  A Van den Broeke; Y Cleuter; T Beskorwayne; P Kerkhofs; M Szynal; C Bagnis; A Burny; P Griebel
Journal:  J Virol       Date:  2001-02       Impact factor: 5.103

8.  In vivo leukocyte tropism of bovine leukemia virus in sheep and cattle.

Authors:  I Schwartz; A Bensaid; B Polack; B Perrin; M Berthelemy; D Levy
Journal:  J Virol       Date:  1994-07       Impact factor: 5.103

9.  Bovine leukemia virus-induced persistent lymphocytosis in cattle does not correlate with increased ex vivo survival of B lymphocytes.

Authors:  F Dequiedt; G H Cantor; V T Hamilton; S M Pritchard; W C Davis; P Kerkhofs; A Burny; R Kettmann; L Willems
Journal:  J Virol       Date:  1999-02       Impact factor: 5.103

10.  In vivo rescue of a silent tax-deficient bovine leukemia virus from a tumor-derived ovine B-cell line by recombination with a retrovirally transduced wild-type tax gene.

Authors:  A Van Den Broeke; C Bagnis; M Ciesiolka; Y Cleuter; H Gelderblom; P Kerkhofs; P Griebel; P Mannoni; A Burny
Journal:  J Virol       Date:  1999-02       Impact factor: 5.103
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