Literature DB >> 21582639

Diethyl (1-hydr-oxy-1-phenyl-ethyl)phospho-nate.

M Nawaz Tahir, Nurcan Acar, Hamza Yilmaz, Muhammad Ilyas Tariq, Ghulam Hussain.   

Abstract

The title compound, C(12)H(19)O(4)P, has a distorted tetra-hedral geometry around the P atom. The molecules form dimers with R(2) (2)(10) ring motifs due to inter-molecular O-H⋯O hydrogen bonds. The double-bonded O atom of the phospho-nate group behaves as an acceptor and the hydr-oxy group acts as a donor. Both of the ethyl groups are disordered with occupancies of 0.55:0.45 and 0.725:0.275.

Entities:  

Year:  2009        PMID： 21582639      PMCID： PMC2969021          DOI： 10.1107/S1600536809011428

Source DB:  PubMed          Journal:  Acta Crystallogr Sect E Struct Rep Online        ISSN： 1600-5368


Related literature

For phospho­nate compounds, see: Acar et al. (2009 ▶); Tahir et al. (2007 ▶, 2009 ▶). For related structures, see: deMendonca et al. (1996 ▶); Feng et al. (2007 ▶). For hydrogen-bond motifs, see: Bernstein et al. (1995 ▶).

Experimental

Crystal data

C12H19O4P M = 258.24 Monoclinic, a = 20.1187 (12) Å b = 8.4488 (14) Å c = 18.4833 (12) Å β = 116.991 (4)° V = 2799.6 (5) Å3 Z = 8 Mo Kα radiation μ = 0.20 mm−1 T = 296 K 0.28 × 0.22 × 0.18 mm

Data collection

Enraf–Nonius CAD-4 diffractometer Absorption correction: ψ scan (MolEN; Fair, 1990 ▶) T min = 0.949, T max = 0.969 2753 measured reflections 2664 independent reflections 1726 reflections with I > 2σ(I) R int = 0.011 3 standard reflections frequency: 120 min intensity decay: −1.2%

Refinement

R[F 2 > 2σ(F 2)] = 0.059 wR(F 2) = 0.197 S = 1.02 2664 reflections 162 parameters 6 restraints H-atom parameters constrained Δρmax = 0.42 e Å−3 Δρmin = −0.41 e Å−3 Data collection: CAD-4 EXPRESS (Enraf–Nonius, 1993 ▶); cell refinement: CAD-4 EXPRESS; data reduction: MolEN (Fair, 1990 ▶); program(s) used to solve structure: SHELXS86 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: ORTEP-3 for Windows (Farrugia, 1997 ▶) and PLATON (Spek, 2009 ▶); software used to prepare material for publication: WinGX (Farrugia, 1999 ▶). Crystal structure: contains datablocks global, I. DOI: 10.1107/S1600536809011428/bq2131sup1.cif Structure factors: contains datablocks I. DOI: 10.1107/S1600536809011428/bq2131Isup2.hkl Additional supplementary materials: crystallographic information; 3D view; checkCIF report
C12H19O4PF(000) = 1104
Mr = 258.24Dx = 1.225 Mg m−3
Monoclinic, C2/cMelting point: 383 K
Hall symbol: -C 2ycMo Kα radiation, λ = 0.71073 Å
a = 20.1187 (12) ÅCell parameters from 25 reflections
b = 8.4488 (14) Åθ = 10.2–18.1°
c = 18.4833 (12) ŵ = 0.20 mm−1
β = 116.991 (4)°T = 296 K
V = 2799.6 (5) Å3Prismatic, colorless
Z = 80.28 × 0.22 × 0.18 mm
Enraf–Nonius CAD-4 diffractometerRint = 0.011
ω/2θ scansθmax = 25.7°, θmin = 2.5°
Absorption correction: ψ scan (MolEN; Fair, 1990)h = −21→24
Tmin = 0.949, Tmax = 0.969k = −10→0
2753 measured reflectionsl = −22→0
2664 independent reflections3 standard reflections every 120 min
1726 reflections with I > 2σ(I) intensity decay: −1.2%
Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.059H-atom parameters constrained
wR(F2) = 0.197w = 1/[σ2(Fo2) + (0.1174P)2 + 1.8226P] where P = (Fo2 + 2Fc2)/3
S = 1.02(Δ/σ)max < 0.001
2664 reflectionsΔρmax = 0.42 e Å−3
162 parametersΔρmin = −0.41 e Å−3
6 restraints
Experimental. The structure was solved by Patterson method using SHELX86. The whole molecule was recognized.
Geometry. Bond distances, angles etc. have been calculated using the rounded fractional coordinates. All su's are estimated from the variances of the (full) variance-covariance matrix. The cell e.s.d.'s are taken into account in the estimation of distances, angles and torsion angles
xyzUiso*/UeqOcc. (<1)
P10.16206 (5)0.43490 (11)0.02880 (5)0.0706 (3)
O10.20371 (14)0.1469 (3)0.07797 (16)0.0810 (9)
O20.19607 (15)0.4445 (3)−0.02609 (15)0.0956 (11)
O30.1602 (2)0.5940 (3)0.07017 (18)0.1071 (13)
O40.07969 (14)0.3787 (4)−0.01170 (14)0.1054 (12)
C10.17069 (15)0.2904 (3)0.16722 (16)0.0604 (9)
C20.1870 (2)0.3950 (5)0.23087 (19)0.0814 (11)
C30.1507 (2)0.3836 (6)0.2789 (2)0.0939 (15)
C40.0982 (2)0.2709 (5)0.2640 (2)0.0892 (15)
C50.0807 (2)0.1687 (5)0.2010 (2)0.0857 (14)
C60.11694 (18)0.1776 (4)0.1532 (2)0.0728 (11)
C70.20991 (16)0.2986 (3)0.11360 (18)0.0642 (10)
C80.29101 (18)0.3474 (5)0.1597 (2)0.0886 (14)
C9A0.1700 (12)0.7452 (17)0.0422 (8)0.108 (2)0.550
C10A0.0980 (6)0.8190 (12)−0.0106 (7)0.108 (2)0.550
C11A0.0250 (5)0.4095 (9)−0.0930 (4)0.127 (2)0.725
C12A−0.0046 (4)0.2635 (9)−0.1369 (4)0.127 (2)0.725
C12B−0.0142 (11)0.364 (3)−0.1501 (12)0.127 (2)0.275
C9B0.1764 (16)0.753 (2)0.0580 (10)0.108 (2)0.450
C10B0.1267 (7)0.8175 (15)−0.0212 (8)0.108 (2)0.450
C11B0.0478 (10)0.285 (3)−0.0825 (10)0.127 (2)0.275
H20.222650.473500.241410.0978*
H30.162500.453930.321720.1125*
H40.074220.263330.296690.1071*
H10.234420.138940.060470.0971*
H8C0.316740.275610.203970.1151*
H9A0.198920.733460.012510.1301*0.550
H9B0.197600.813350.088500.1301*0.550
H10A0.073970.76033−0.060320.1410*0.550
H10B0.106080.92596−0.022290.1410*0.550
H10C0.066930.819050.016370.1410*0.550
H11A0.047190.47110−0.120640.1519*0.725
H11B−0.015360.47112−0.092110.1519*0.725
H12A−0.025370.28317−0.194140.1646*0.725
H12B−0.042850.22371−0.124240.1646*0.725
H12C0.034710.18690−0.121310.1646*0.725
H50.043990.092450.190030.1028*
H60.104840.106080.110790.0872*
H8A0.294010.452760.180450.1151*
H8B0.313670.344900.123830.1151*
H9C0.227180.758260.064950.1301*0.450
H9D0.173780.819670.099450.1301*0.450
H10D0.075900.79776−0.032400.1410*0.450
H10E0.136590.76753−0.061910.1410*0.450
H10F0.134620.92943−0.021490.1410*0.450
H11C0.030100.18697−0.070320.1519*0.275
H11D0.085970.25945−0.098890.1519*0.275
H12D−0.004590.36632−0.196390.1646*0.275
H12E−0.019320.46968−0.134690.1646*0.275
H12F−0.059480.30603−0.163500.1646*0.276
U11U22U33U12U13U23
P10.0724 (5)0.0812 (6)0.0660 (5)0.0143 (4)0.0382 (4)0.0060 (4)
O10.0893 (16)0.0692 (14)0.1046 (17)0.0017 (12)0.0616 (14)−0.0126 (13)
O20.1085 (19)0.109 (2)0.0973 (17)0.0255 (15)0.0711 (16)0.0183 (15)
O30.170 (3)0.0692 (16)0.1128 (19)0.0340 (16)0.091 (2)0.0190 (14)
O40.0682 (15)0.174 (3)0.0634 (13)0.0083 (16)0.0207 (11)0.0125 (16)
C10.0563 (15)0.0638 (18)0.0544 (14)0.0051 (13)0.0193 (12)0.0006 (13)
C20.080 (2)0.088 (2)0.0687 (19)−0.0086 (18)0.0271 (17)−0.0128 (17)
C30.101 (3)0.119 (3)0.0617 (19)−0.001 (2)0.0370 (19)−0.020 (2)
C40.093 (3)0.117 (3)0.0685 (19)0.005 (2)0.0463 (19)0.006 (2)
C50.082 (2)0.093 (3)0.091 (2)−0.0069 (19)0.047 (2)0.004 (2)
C60.074 (2)0.074 (2)0.0723 (18)−0.0027 (16)0.0350 (16)−0.0083 (16)
C70.0605 (16)0.0632 (18)0.0701 (17)0.0023 (14)0.0308 (14)−0.0045 (15)
C80.0603 (19)0.098 (3)0.098 (2)−0.0004 (18)0.0275 (18)0.001 (2)
C9A0.114 (4)0.088 (2)0.117 (4)−0.001 (2)0.048 (3)−0.003 (2)
C10A0.114 (4)0.088 (2)0.117 (4)−0.001 (2)0.048 (3)−0.003 (2)
C11A0.118 (4)0.119 (4)0.105 (3)−0.008 (3)0.017 (3)−0.009 (3)
C12A0.118 (4)0.119 (4)0.105 (3)−0.008 (3)0.017 (3)−0.009 (3)
C12B0.118 (4)0.119 (4)0.105 (3)−0.008 (3)0.017 (3)−0.009 (3)
C9B0.114 (4)0.088 (2)0.117 (4)−0.001 (2)0.048 (3)−0.003 (2)
C10B0.114 (4)0.088 (2)0.117 (4)−0.001 (2)0.048 (3)−0.003 (2)
C11B0.118 (4)0.119 (4)0.105 (3)−0.008 (3)0.017 (3)−0.009 (3)
P1—O21.461 (3)C5—H50.9300
P1—O31.555 (3)C6—H60.9300
P1—O41.551 (3)C8—H8A0.9600
P1—C71.828 (3)C8—H8B0.9600
O1—C71.420 (4)C8—H8C0.9600
O3—C9A1.425 (16)C9A—H9A0.9700
O3—C9B1.424 (19)C9A—H9B0.9700
O4—C11A1.427 (7)C9B—H9C0.9700
O4—C11B1.41 (2)C9B—H9D0.9700
O1—H10.8200C10A—H10A0.9600
C1—C21.387 (4)C10A—H10C0.9600
C1—C61.375 (5)C10A—H10B0.9600
C1—C71.523 (5)C10B—H10E0.9600
C2—C31.385 (6)C10B—H10D0.9600
C3—C41.354 (6)C10B—H10F0.9600
C4—C51.361 (5)C11A—H11A0.9700
C5—C61.379 (6)C11A—H11B0.9700
C7—C81.515 (5)C11B—H11C0.9700
C9A—C10A1.47 (2)C11B—H11D0.9700
C9B—C10B1.45 (2)C12A—H12A0.9600
C11A—C12A1.448 (11)C12A—H12B0.9600
C11B—C12B1.47 (3)C12A—H12C0.9600
C2—H20.9300C12B—H12D0.9600
C3—H30.9300C12B—H12E0.9600
C4—H40.9300
P1···H10E3.1900C8···H22.6800
O1···O23.127 (4)C12B···H12Dix3.0300
O1···O43.009 (4)H1···O2ii1.9100
O1···C9Bi3.366 (17)H1···H10Fi2.5900
O1···O2ii2.709 (4)H1···H8B2.2900
O1···C11B3.399 (19)H2···C82.6800
O1···C10Bi3.306 (13)H2···H8A2.2000
O2···O1ii2.709 (4)H3···O2viii2.7200
O2···O13.127 (4)H4···H10Eviii2.3400
O3···C23.238 (5)H6···O12.3500
O4···C63.266 (4)H8A···C22.7500
O4···O13.009 (4)H8A···O32.8000
O1···H10Fi2.5200H8A···C5vii3.0800
O1···H9Bi2.8300H8A···H22.2000
O1···H10Bi2.7300H8B···O22.8300
O1···H9Di2.8900H8B···H11Dii2.4300
O1···H62.3500H8B···H12.2900
O2···H9A2.5400H8C···C23.0400
O2···H3iii2.7200H9A···H9Ax2.3200
O2···H1ii1.9100H9A···O22.5400
O2···H8B2.8300H9B···O1vi2.8300
O2···H11A2.7100H9B···C3vii2.9800
O2···H11D2.5400H9C···C3vii3.0100
O3···H8A2.8000H9D···O1vi2.8900
C2···O33.238 (5)H10A···C5iv3.0800
C3···C12Biv3.44 (2)H10B···O1vi2.7300
C3···C9Bv3.59 (2)H10B···H11Cvi2.6000
C6···O43.266 (4)H10C···H11Civ2.5600
C9B···O1vi3.366 (17)H10E···C4iii2.9700
C9B···C3vii3.59 (2)H10E···P13.1900
C10B···O1vi3.306 (13)H10E···H4iii2.3400
C11B···O13.399 (19)H10F···H1vi2.5900
C12B···C3iv3.44 (2)H10F···O1vi2.5200
C2···H8A2.7500H11A···O22.7100
C2···H8C3.0400H11C···H10Bi2.6000
C3···H12Eiv3.0400H11C···H10Civ2.5600
C3···H9Bv2.9800H11D···O22.5400
C3···H9Cv3.0100H11D···H8Bii2.4300
C4···H12Eiv3.1000H12D···C12Bix3.0300
C4···H10Eviii2.9700H12D···H12Dix2.0700
C5···H10Aiv3.0800H12E···C3iv3.0400
C5···H8Av3.0800H12E···C4iv3.1000
O2—P1—O3114.63 (18)H8A—C8—H8C109.00
O2—P1—O4114.61 (15)H8B—C8—H8C109.00
O2—P1—C7113.59 (16)O3—C9A—H9A109.00
O3—P1—O4104.1 (2)O3—C9A—H9B109.00
O3—P1—C7104.11 (14)C10A—C9A—H9A109.00
O4—P1—C7104.63 (16)C10A—C9A—H9B109.00
P1—O3—C9A123.9 (7)H9A—C9A—H9B108.00
P1—O3—C9B132.8 (10)O3—C9B—H9D109.00
P1—O4—C11A126.6 (4)C10B—C9B—H9C109.00
P1—O4—C11B123.8 (9)O3—C9B—H9C109.00
C7—O1—H1109.00H9C—C9B—H9D107.00
C2—C1—C7122.0 (3)C10B—C9B—H9D109.00
C6—C1—C7120.3 (3)C9A—C10A—H10B109.00
C2—C1—C6117.7 (3)C9A—C10A—H10A109.00
C1—C2—C3120.6 (4)C9A—C10A—H10C109.00
C2—C3—C4120.5 (4)H10A—C10A—H10B110.00
C3—C4—C5119.7 (4)H10A—C10A—H10C109.00
C4—C5—C6120.4 (4)H10B—C10A—H10C109.00
C1—C6—C5121.1 (3)C9B—C10B—H10E109.00
P1—C7—C1111.1 (2)C9B—C10B—H10F110.00
P1—C7—C8108.9 (2)C9B—C10B—H10D109.00
P1—C7—O1105.7 (2)H10D—C10B—H10E109.00
O1—C7—C8110.6 (3)H10D—C10B—H10F109.00
C1—C7—C8113.0 (3)H10E—C10B—H10F110.00
O1—C7—C1107.4 (2)O4—C11A—H11A109.00
O3—C9A—C10A111.4 (16)O4—C11A—H11B109.00
O3—C9B—C10B114.3 (16)C12A—C11A—H11A109.00
O4—C11A—C12A111.1 (6)C12A—C11A—H11B109.00
O4—C11B—C12B112.8 (19)H11A—C11A—H11B108.00
C1—C2—H2120.00O4—C11B—H11C109.00
C3—C2—H2120.00C12B—C11B—H11D109.00
C2—C3—H3120.00O4—C11B—H11D109.00
C4—C3—H3120.00C12B—C11B—H11C109.00
C3—C4—H4120.00H11C—C11B—H11D108.00
C5—C4—H4120.00C11A—C12A—H12B109.00
C4—C5—H5120.00C11A—C12A—H12C109.00
C6—C5—H5120.00C11A—C12A—H12A109.00
C1—C6—H6119.00H12A—C12A—H12C110.00
C5—C6—H6119.00H12B—C12A—H12C109.00
C7—C8—H8A109.00H12A—C12A—H12B109.00
C7—C8—H8B109.00C11B—C12B—H12D109.00
C7—C8—H8C110.00C11B—C12B—H12E110.00
H8A—C8—H8B109.00H12D—C12B—H12E110.00
O2—P1—O3—C9A17.3 (11)P1—O4—C11A—C12A121.8 (6)
O4—P1—O3—C9A−108.6 (11)C6—C1—C2—C30.9 (5)
C7—P1—O3—C9A142.0 (11)C7—C1—C2—C3−179.5 (3)
O2—P1—O4—C11A−33.3 (5)C2—C1—C6—C5−0.2 (5)
O3—P1—O4—C11A92.7 (5)C7—C1—C6—C5−179.8 (3)
C7—P1—O4—C11A−158.4 (5)C2—C1—C7—P1−87.5 (3)
O2—P1—C7—O1−62.4 (3)C2—C1—C7—O1157.5 (3)
O2—P1—C7—C1−178.45 (19)C2—C1—C7—C835.3 (4)
O2—P1—C7—C856.5 (3)C6—C1—C7—P192.2 (3)
O3—P1—C7—O1172.3 (3)C6—C1—C7—O1−22.9 (4)
O3—P1—C7—C156.2 (3)C6—C1—C7—C8−145.1 (3)
O3—P1—C7—C8−68.9 (3)C1—C2—C3—C4−0.6 (6)
O4—P1—C7—O163.4 (3)C2—C3—C4—C5−0.4 (6)
O4—P1—C7—C1−52.8 (2)C3—C4—C5—C61.1 (6)
O4—P1—C7—C8−177.8 (2)C4—C5—C6—C1−0.8 (6)
P1—O3—C9A—C10A95.4 (14)
D—H···AD—HH···AD···AD—H···A
O1—H1···O2ii0.82001.91002.709 (4)163.00
Table 1

Selected bond lengths (Å)

P1—O21.461 (3)
P1—O31.555 (3)
P1—O41.551 (3)
P1—C71.828 (3)
O1—C71.420 (4)
Table 2

Hydrogen-bond geometry (Å, °)

D—H⋯AD—HH⋯AD⋯AD—H⋯A
O1—H1⋯O2i0.82001.91002.709 (4)163.00

Symmetry code: (i) .

  4 in total

1.  A short history of SHELX.

Authors:  George M Sheldrick
Journal:  Acta Crystallogr A       Date:  2007-12-21       Impact factor: 2.290

2.  Dimethyl [hydr-oxy(2-nitro-phen-yl)meth-yl]phospho-nate.

Authors:  M Nawaz Tahir; Nurcan Acar; Hamza Yilmaz; Muhammad Ilyas Tariq; Dinçer Ulkü
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-02-21

3.  Dimethyl (1-hydr-oxy-1,2-diphenyl-ethyl)phospho-nate.

Authors:  Nurcan Acar; M Nawaz Tahir; Hamza Yılmaz; Muhammad Saeed Ahmad Chishti; Muhammad Ali Malik
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-02-06

4.  Structure validation in chemical crystallography.

Authors:  Anthony L Spek
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2009-01-20
  4 in total
  2 in total

1.  Dimethyl (1-hydr-oxy-1,2-diphenyl-ethyl)phospho-nate.

Authors:  M Nawaz Tahir; Nurcan Acar; Hamza Yilmaz; Riaz H Tariq
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-07-31

2.  Diethyl (1-hydr-oxy-1,2-diphenyl-ethyl)phospho-nate.

Authors:  Nurcan Acar; M Nawaz Tahir; Riaz H Tariq; Hamza Yilmaz
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-05-07
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.