8-Phenyl-10-oxa-8-aza-tricyclo-[4.3.0.1]decane-7,9-dione.

The reaction of aniline with norcantharidin produced the imide title compound, C(14)H(13)NO(3), which shows no significant hydrogen bonds in the crystal structure. The dihedral angle between the phenyl and pyrrolidine rings is 48.48 (6)°.

Related literature

For the use of norcantharidin in synthesis see: Hill et al. (2007 ▶). For background, see: Wang (1989 ▶).

Experimental

Crystal data

C14H13NO3

M = 243.25

Monoclinic,

a = 9.5914 (4) Å

b = 8.4345 (3) Å

c = 14.4101 (6) Å

β = 93.468 (3)°

V = 1163.62 (8) Å3

Z = 4

Mo Kα radiation

μ = 0.10 mm−1

T = 296 (2) K

0.32 × 0.25 × 0.04 mm

Data collection

Bruker APEXII CCD area-detector diffractometer

Absorption correction: multi-scan (SADABS; Sheldrick, 1996 ▶) T min = 0.971, T max = 0.996

18085 measured reflections

2699 independent reflections

1898 reflections with I > 2σ(I)

R int = 0.041

Refinement

R[F 2 > 2σ(F 2)] = 0.041

wR(F 2) = 0.177

S = 0.61

2699 reflections

163 parameters

H-atom parameters constrained

Δρmax = 0.16 e Å−3

Δρmin = −0.17 e Å−3

Data collection: APEX2 (Bruker, 2004 ▶); cell refinement: SAINT (Bruker, 2004 ▶); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: SHELXTL (Sheldrick, 2008 ▶); software used to prepare material for publication: SHELXL97.

Crystal structure: contains datablocks I, global. DOI: 10.1107/S1600536809000282/at2701sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536809000282/at2701Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

C14H13NO3	F(000) = 512
Mr = 243.25	Dx = 1.389 Mg m−3Dm = 1.389 Mg m−3Dm measured by not measured
Monoclinic, P21/c	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2ybc	Cell parameters from 3324 reflections
a = 9.5914 (4) Å	θ = 2.1–27.7°
b = 8.4345 (3) Å	µ = 0.10 mm−1
c = 14.4101 (6) Å	T = 296 K
β = 93.468 (3)°	Sheet, colourless
V = 1163.62 (8) Å3	0.32 × 0.25 × 0.04 mm
Z = 4

Bruker SMART CCD area-detector diffractometer	2699 independent reflections
Radiation source: fine-focus sealed tube	1898 reflections with I > 2σ(I)
graphite	Rint = 0.041
φ and ω scans	θmax = 27.7°, θmin = 2.1°
Absorption correction: multi-scan (SADABS; Sheldrick, 1996)	h = −12→12
Tmin = 0.971, Tmax = 0.996	k = −11→10
18085 measured reflections	l = −18→18

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.041	Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.177	H-atom parameters constrained
S = 0.61	w = 1/[σ2(Fo2) + (0.1908P)2 + 0.6671P] where P = (Fo2 + 2Fc2)/3
2699 reflections	(Δ/σ)max < 0.001
163 parameters	Δρmax = 0.16 e Å−3
0 restraints	Δρmin = −0.17 e Å−3

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

	x	y	z	Uiso*/Ueq
N1	0.10268 (15)	0.22038 (16)	0.69370 (9)	0.0418 (4)
O1	−0.04620 (15)	0.1156 (2)	0.79702 (10)	0.0655 (4)
O2	0.19084 (14)	0.33610 (17)	0.56481 (9)	0.0579 (4)
O3	−0.13027 (14)	0.06451 (14)	0.54810 (10)	0.0526 (4)
C1	0.32246 (19)	0.0814 (2)	0.68510 (13)	0.0513 (4)
H1A	0.3026	0.0665	0.6217	0.062*
C2	0.4439 (2)	0.0209 (3)	0.72752 (17)	0.0620 (5)
H2A	0.5055	−0.0358	0.6927	0.074*
C3	0.4743 (2)	0.0442 (3)	0.82150 (17)	0.0646 (6)
H3A	0.5562	0.0034	0.8499	0.078*
C4	0.3832 (2)	0.1278 (2)	0.87295 (15)	0.0599 (5)
H4A	0.4042	0.1435	0.9361	0.072*
C5	0.2603 (2)	0.1891 (2)	0.83178 (13)	0.0493 (4)
H5A	0.1989	0.2457	0.8668	0.059*
C6	0.23040 (18)	0.16445 (19)	0.73715 (12)	0.0421 (4)
C7	0.09220 (19)	0.29901 (19)	0.60787 (11)	0.0432 (4)
C8	−0.05956 (18)	0.32348 (19)	0.57997 (11)	0.0432 (4)
H8A	−0.0820	0.4349	0.5668	0.052*
C9	−0.1114 (2)	0.2122 (2)	0.50018 (13)	0.0502 (4)
H9A	−0.0485	0.2054	0.4492	0.060*
C10	−0.2605 (2)	0.2614 (3)	0.46982 (14)	0.0592 (5)
H10A	−0.2906	0.2148	0.4104	0.071*
H10B	−0.2696	0.3758	0.4659	0.071*
C11	−0.3429 (2)	0.1933 (2)	0.54908 (16)	0.0585 (5)
H11A	−0.3931	0.2756	0.5802	0.070*
H11B	−0.4082	0.1120	0.5267	0.070*
C12	−0.22552 (19)	0.1238 (2)	0.61262 (14)	0.0488 (4)
H12A	−0.2570	0.0432	0.6556	0.059*
C13	−0.13944 (18)	0.25713 (19)	0.66061 (11)	0.0430 (4)
H13A	−0.1973	0.3369	0.6894	0.052*
C14	−0.02839 (18)	0.1892 (2)	0.72702 (12)	0.0449 (4)

	U11	U22	U33	U12	U13	U23
N1	0.0422 (8)	0.0437 (7)	0.0400 (7)	0.0010 (6)	0.0060 (6)	0.0082 (6)
O1	0.0549 (8)	0.0882 (11)	0.0546 (8)	0.0025 (7)	0.0131 (6)	0.0281 (7)
O2	0.0542 (8)	0.0651 (8)	0.0555 (8)	−0.0097 (6)	0.0127 (6)	0.0158 (6)
O3	0.0538 (7)	0.0369 (6)	0.0678 (8)	0.0025 (5)	0.0099 (6)	−0.0059 (5)
C1	0.0465 (10)	0.0543 (10)	0.0534 (10)	−0.0008 (8)	0.0072 (8)	−0.0011 (8)
C2	0.0440 (10)	0.0628 (12)	0.0799 (14)	0.0028 (9)	0.0097 (9)	0.0026 (10)
C3	0.0417 (10)	0.0654 (13)	0.0851 (15)	−0.0065 (9)	−0.0098 (10)	0.0115 (11)
C4	0.0588 (12)	0.0611 (12)	0.0580 (11)	−0.0136 (9)	−0.0121 (9)	0.0061 (9)
C5	0.0533 (10)	0.0465 (9)	0.0481 (9)	−0.0053 (8)	0.0025 (8)	0.0012 (7)
C6	0.0414 (8)	0.0397 (8)	0.0456 (9)	−0.0038 (6)	0.0042 (7)	0.0050 (7)
C7	0.0486 (9)	0.0398 (8)	0.0415 (8)	−0.0053 (7)	0.0059 (7)	0.0044 (6)
C8	0.0490 (9)	0.0359 (8)	0.0444 (9)	−0.0014 (7)	0.0015 (7)	0.0053 (6)
C9	0.0568 (11)	0.0490 (9)	0.0450 (9)	−0.0032 (8)	0.0053 (8)	−0.0019 (7)
C10	0.0640 (13)	0.0534 (10)	0.0579 (11)	−0.0032 (9)	−0.0139 (9)	−0.0036 (9)
C11	0.0462 (10)	0.0540 (11)	0.0741 (13)	0.0006 (8)	−0.0060 (9)	−0.0081 (9)
C12	0.0434 (9)	0.0398 (8)	0.0639 (11)	−0.0005 (7)	0.0090 (8)	0.0043 (8)
C13	0.0441 (9)	0.0396 (8)	0.0459 (9)	0.0050 (7)	0.0082 (7)	0.0018 (7)
C14	0.0434 (9)	0.0472 (9)	0.0450 (9)	0.0024 (7)	0.0100 (7)	0.0044 (7)

N1—C14	1.398 (2)	C5—H5A	0.9300
N1—C7	1.402 (2)	C7—C8	1.501 (2)
N1—C6	1.422 (2)	C8—C13	1.536 (2)
O1—C14	1.205 (2)	C8—C9	1.543 (2)
O2—C7	1.204 (2)	C8—H8A	0.9800
O3—C12	1.433 (2)	C9—C10	1.528 (3)
O3—C9	1.441 (2)	C9—H9A	0.9800
C1—C2	1.380 (3)	C10—C11	1.539 (3)
C1—C6	1.383 (2)	C10—H10A	0.9700
C1—H1A	0.9300	C10—H10B	0.9700
C2—C3	1.382 (3)	C11—C12	1.525 (3)
C2—H2A	0.9300	C11—H11A	0.9700
C3—C4	1.374 (3)	C11—H11B	0.9700
C3—H3A	0.9300	C12—C13	1.535 (2)
C4—C5	1.387 (3)	C12—H12A	0.9800
C4—H4A	0.9300	C13—C14	1.502 (2)
C5—C6	1.392 (3)	C13—H13A	0.9800
C14—N1—C7	111.99 (14)	O3—C9—C8	102.29 (14)
C14—N1—C6	123.71 (14)	C10—C9—C8	107.58 (15)
C7—N1—C6	124.01 (14)	O3—C9—H9A	114.2
C12—O3—C9	96.47 (12)	C10—C9—H9A	114.2
C2—C1—C6	119.77 (18)	C8—C9—H9A	114.2
C2—C1—H1A	120.1	C9—C10—C11	101.54 (15)
C6—C1—H1A	120.1	C9—C10—H10A	111.5
C1—C2—C3	120.2 (2)	C11—C10—H10A	111.5
C1—C2—H2A	119.9	C9—C10—H10B	111.5
C3—C2—H2A	119.9	C11—C10—H10B	111.5
C4—C3—C2	119.91 (19)	H10A—C10—H10B	109.3
C4—C3—H3A	120.0	C12—C11—C10	101.26 (16)
C2—C3—H3A	120.0	C12—C11—H11A	111.5
C3—C4—C5	120.8 (2)	C10—C11—H11A	111.5
C3—C4—H4A	119.6	C12—C11—H11B	111.5
C5—C4—H4A	119.6	C10—C11—H11B	111.5
C4—C5—C6	118.85 (18)	H11A—C11—H11B	109.3
C4—C5—H5A	120.6	O3—C12—C11	102.78 (16)
C6—C5—H5A	120.6	O3—C12—C13	101.63 (13)
C1—C6—C5	120.45 (17)	C11—C12—C13	110.30 (14)
C1—C6—N1	119.36 (16)	O3—C12—H12A	113.7
C5—C6—N1	120.16 (16)	C11—C12—H12A	113.7
O2—C7—N1	124.14 (17)	C13—C12—H12A	113.7
O2—C7—C8	127.30 (15)	C14—C13—C12	110.43 (14)
N1—C7—C8	108.55 (14)	C14—C13—C8	104.73 (14)
C7—C8—C13	105.51 (13)	C12—C13—C8	101.86 (13)
C7—C8—C9	112.30 (14)	C14—C13—H13A	113.0
C13—C8—C9	100.91 (14)	C12—C13—H13A	113.0
C7—C8—H8A	112.5	C8—C13—H13A	113.0
C13—C8—H8A	112.5	O1—C14—N1	124.09 (17)
C9—C8—H8A	112.5	O1—C14—C13	126.79 (16)
O3—C9—C10	103.26 (15)	N1—C14—C13	109.10 (14)
C6—C1—C2—C3	−0.6 (3)	C13—C8—C9—C10	74.97 (17)
C1—C2—C3—C4	0.1 (3)	O3—C9—C10—C11	31.94 (17)
C2—C3—C4—C5	0.2 (3)	C8—C9—C10—C11	−75.77 (17)
C3—C4—C5—C6	0.0 (3)	C9—C10—C11—C12	2.39 (18)
C2—C1—C6—C5	0.8 (3)	C9—O3—C12—C11	56.48 (16)
C2—C1—C6—N1	−177.25 (17)	C9—O3—C12—C13	−57.71 (15)
C4—C5—C6—C1	−0.6 (3)	C10—C11—C12—O3	−36.30 (17)
C4—C5—C6—N1	177.52 (16)	C10—C11—C12—C13	71.41 (18)
C14—N1—C6—C1	126.96 (18)	O3—C12—C13—C14	−74.48 (16)
C7—N1—C6—C1	−46.3 (2)	C11—C12—C13—C14	177.05 (15)
C14—N1—C6—C5	−51.1 (2)	O3—C12—C13—C8	36.33 (16)
C7—N1—C6—C5	135.62 (17)	C11—C12—C13—C8	−72.14 (17)
C14—N1—C7—O2	−178.77 (17)	C7—C8—C13—C14	−3.54 (17)
C6—N1—C7—O2	−4.8 (3)	C9—C8—C13—C14	113.50 (15)
C14—N1—C7—C8	−0.10 (19)	C7—C8—C13—C12	−118.62 (14)
C6—N1—C7—C8	173.85 (14)	C9—C8—C13—C12	−1.58 (16)
O2—C7—C8—C13	−179.03 (18)	C7—N1—C14—O1	176.01 (17)
N1—C7—C8—C13	2.35 (18)	C6—N1—C14—O1	2.0 (3)
O2—C7—C8—C9	71.9 (2)	C7—N1—C14—C13	−2.3 (2)
N1—C7—C8—C9	−106.67 (16)	C6—N1—C14—C13	−176.26 (14)
C12—O3—C9—C10	−54.79 (16)	C12—C13—C14—O1	−65.7 (2)
C12—O3—C9—C8	56.86 (16)	C8—C13—C14—O1	−174.64 (18)
C7—C8—C9—O3	78.51 (17)	C12—C13—C14—N1	112.55 (16)
C13—C8—C9—O3	−33.41 (16)	C8—C13—C14—N1	3.61 (18)
C7—C8—C9—C10	−173.12 (14)

D—H···A	D—H	H···A	D···A	D—H···A
C10—H10B···O2i	0.97	2.59	3.502 (3)	156

Table 1

Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
C10—H10B⋯O2i	0.97	2.59	3.502 (3)	156

Symmetry code: (i) .