(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)(2,6-difluoro-phen-yl)methanone.

There are two mol-ecules in the asymmetric unit of the title compound, C(12)H(9)BrF(2)N(2)O. They have very similar conformations: the dihedral angles between their pyrazole and benzene ring systems are 78.4 (3) and 78.6 (4)°. In the crystal, weak aromatic π-π stacking [centroid-centroid separation = 3.696 (5) Å] helps to establish the packing.

Related literature

For background to pyrazole derivatives in agrochemical and medicinal research, see: Sabbagh et al. (2009 ▶); Zheng et al. (2009 ▶).

Experimental

Crystal data

C12H9BrF2N2O

M = 315.12

Monoclinic,

a = 7.116 (3) Å

b = 29.304 (10) Å

c = 11.674 (4) Å

β = 91.533 (5)°

V = 2433.5 (15) Å3

Z = 8

Mo Kα radiation

μ = 3.39 mm−1

T = 173 K

0.17 × 0.17 × 0.17 mm

Data collection

Rigaku Saturn724+ CCD diffractometer

Absorption correction: numerical (CrystalClear; Rigaku, 2008 ▶) T min = 0.596, T max = 0.596

15188 measured reflections

4276 independent reflections

3819 reflections with I > 2σ(I)

R int = 0.060

Refinement

R[F 2 > 2σ(F 2)] = 0.077

wR(F 2) = 0.158

S = 1.27

4276 reflections

329 parameters

H-atom parameters constrained

Δρmax = 1.08 e Å−3

Δρmin = −0.47 e Å−3

Data collection: CrystalClear (Rigaku, 2008 ▶); cell refinement: CrystalClear; data reduction: CrystalClear; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: SHELXTL (Sheldrick, 2008 ▶); software used to prepare material for publication: SHELXL97.

Crystal structure: contains datablocks I, global. DOI: 10.1107/S1600536809052532/hb5260sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536809052532/hb5260Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

C12H9BrF2N2O	F(000) = 1248
Mr = 315.12	Dx = 1.720 Mg m−3
Monoclinic, P21/c	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2ybc	Cell parameters from 768 reflections
a = 7.116 (3) Å	θ = 2.2–27.5°
b = 29.304 (10) Å	µ = 3.39 mm−1
c = 11.674 (4) Å	T = 173 K
β = 91.533 (5)°	Block, colourless
V = 2433.5 (15) Å3	0.17 × 0.17 × 0.17 mm
Z = 8

Rigaku Saturn724+ CCD diffractometer	4276 independent reflections
Radiation source: sealed tube	3819 reflections with I > 2σ(I)
graphite	Rint = 0.060
ω scans at fixed χ = 45°	θmax = 25.0°, θmin = 2.8°
Absorption correction: numerical (CrystalClear; Rigaku, 2008)	h = −6→8
Tmin = 0.596, Tmax = 0.596	k = −34→34
15188 measured reflections	l = −12→13

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.077	Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.158	H-atom parameters constrained
S = 1.27	w = 1/[σ2(Fo2) + (0.0402P)2 + 7.5951P] where P = (Fo2 + 2Fc2)/3
4276 reflections	(Δ/σ)max < 0.001
329 parameters	Δρmax = 1.08 e Å−3
0 restraints	Δρmin = −0.47 e Å−3

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

	x	y	z	Uiso*/Ueq
Br1	0.48772 (10)	0.41014 (2)	0.89703 (6)	0.0409 (2)
Br2	1.00200 (10)	0.31950 (3)	1.09739 (6)	0.0491 (3)
F1	0.7911 (6)	0.30667 (16)	1.4485 (4)	0.0586 (12)
F2	0.1573 (5)	0.32948 (15)	1.3484 (3)	0.0503 (11)
F3	0.6692 (7)	0.42324 (19)	0.6390 (5)	0.0780 (16)
F4	1.3057 (7)	0.4580 (2)	0.6345 (6)	0.0889 (18)
O1	0.5532 (8)	0.26916 (16)	1.2410 (4)	0.0534 (14)
O2	1.0003 (10)	0.48031 (17)	0.8138 (4)	0.0649 (17)
N1	0.5031 (7)	0.34346 (17)	1.1966 (4)	0.0298 (12)
N2	0.4946 (7)	0.38788 (17)	1.2406 (5)	0.0322 (12)
N3	0.9873 (7)	0.40262 (16)	0.8255 (4)	0.0290 (12)
N4	0.9923 (7)	0.36189 (17)	0.7664 (4)	0.0303 (12)
C1	0.4918 (9)	0.4144 (2)	1.1501 (6)	0.0323 (15)
C2	0.4947 (9)	0.3874 (2)	1.0474 (5)	0.0304 (14)
C3	0.5023 (8)	0.3431 (2)	1.0775 (5)	0.0287 (14)
C4	0.4855 (11)	0.4650 (2)	1.1623 (6)	0.0431 (17)
H4A	0.4898	0.4731	1.2438	0.065*
H4B	0.3690	0.4767	1.1265	0.065*
H4C	0.5936	0.4785	1.1247	0.065*
C5	0.5039 (10)	0.3009 (2)	1.0060 (6)	0.0380 (16)
H5A	0.4885	0.3092	0.9250	0.057*
H5B	0.4005	0.2809	1.0279	0.057*
H5C	0.6238	0.2850	1.0183	0.057*
C6	0.5157 (10)	0.3064 (2)	1.2725 (5)	0.0351 (15)
C7	0.4758 (9)	0.3177 (2)	1.3954 (5)	0.0302 (14)
C8	0.6131 (9)	0.3157 (2)	1.4813 (6)	0.0362 (16)
C9	0.5761 (11)	0.3226 (2)	1.5946 (6)	0.0434 (18)
H9A	0.6742	0.3219	1.6513	0.052*
C10	0.3931 (10)	0.3306 (2)	1.6239 (6)	0.0387 (16)
H10A	0.3650	0.3341	1.7025	0.046*
C11	0.2501 (10)	0.3337 (2)	1.5433 (6)	0.0409 (17)
H11A	0.1250	0.3405	1.5642	0.049*
C12	0.2950 (9)	0.3266 (2)	1.4315 (6)	0.0355 (15)
C13	0.9966 (9)	0.3303 (2)	0.8459 (6)	0.0330 (15)
C14	0.9948 (9)	0.3504 (2)	0.9562 (5)	0.0325 (15)
C15	0.9901 (9)	0.3960 (2)	0.9434 (5)	0.0339 (15)
C16	1.0047 (12)	0.2810 (2)	0.8158 (7)	0.051 (2)
H16A	1.0217	0.2777	0.7332	0.076*
H16B	0.8872	0.2661	0.8369	0.076*
H16C	1.1105	0.2666	0.8575	0.076*
C17	0.9875 (11)	0.4331 (3)	1.0304 (6)	0.0481 (19)
H17A	0.9903	0.4197	1.1074	0.072*
H17B	0.8729	0.4512	1.0195	0.072*
H17C	1.0977	0.4527	1.0217	0.072*
C18	0.9919 (10)	0.4439 (2)	0.7649 (6)	0.0378 (16)
C19	0.9876 (10)	0.4396 (2)	0.6374 (6)	0.0374 (16)
C20	0.8243 (12)	0.4300 (3)	0.5776 (7)	0.052 (2)
C21	0.8162 (19)	0.4272 (3)	0.4604 (8)	0.087 (4)
H21A	0.7018	0.4200	0.4206	0.105*
C22	0.975 (2)	0.4350 (3)	0.4030 (8)	0.100 (5)
H22A	0.9711	0.4331	0.3217	0.120*
C23	1.141 (2)	0.4456 (4)	0.4571 (10)	0.090 (4)
H23A	1.2508	0.4512	0.4148	0.108*
C24	1.1454 (13)	0.4478 (3)	0.5754 (7)	0.058 (2)

	U11	U22	U33	U12	U13	U23
Br1	0.0507 (5)	0.0423 (4)	0.0296 (4)	−0.0035 (3)	0.0003 (3)	0.0051 (3)
Br2	0.0450 (4)	0.0693 (6)	0.0328 (4)	−0.0021 (4)	−0.0021 (3)	0.0171 (4)
F1	0.036 (2)	0.073 (3)	0.067 (3)	0.004 (2)	0.001 (2)	−0.013 (2)
F2	0.039 (2)	0.071 (3)	0.041 (2)	0.006 (2)	−0.0080 (19)	−0.004 (2)
F3	0.055 (3)	0.076 (4)	0.102 (4)	−0.014 (3)	−0.013 (3)	0.008 (3)
F4	0.049 (3)	0.093 (4)	0.126 (5)	−0.006 (3)	0.018 (3)	−0.001 (4)
O1	0.095 (4)	0.021 (2)	0.044 (3)	0.013 (3)	0.016 (3)	0.000 (2)
O2	0.124 (5)	0.029 (3)	0.042 (3)	0.000 (3)	0.002 (3)	−0.002 (2)
N1	0.036 (3)	0.027 (3)	0.026 (3)	−0.002 (2)	0.001 (2)	−0.003 (2)
N2	0.040 (3)	0.024 (3)	0.033 (3)	0.000 (2)	0.002 (2)	0.000 (2)
N3	0.037 (3)	0.023 (3)	0.027 (3)	0.001 (2)	0.000 (2)	−0.003 (2)
N4	0.039 (3)	0.025 (3)	0.027 (3)	−0.003 (2)	0.001 (2)	−0.005 (2)
C1	0.039 (4)	0.025 (3)	0.033 (4)	−0.001 (3)	0.004 (3)	0.000 (3)
C2	0.040 (4)	0.028 (3)	0.024 (3)	0.001 (3)	0.007 (3)	0.001 (3)
C3	0.029 (3)	0.028 (3)	0.029 (3)	−0.001 (3)	0.004 (3)	−0.002 (3)
C4	0.058 (5)	0.027 (4)	0.044 (4)	−0.007 (3)	−0.001 (4)	0.000 (3)
C5	0.047 (4)	0.035 (4)	0.032 (4)	−0.005 (3)	0.001 (3)	−0.006 (3)
C6	0.044 (4)	0.035 (4)	0.027 (4)	0.002 (3)	0.004 (3)	0.002 (3)
C7	0.041 (4)	0.020 (3)	0.030 (4)	0.000 (3)	0.002 (3)	0.000 (3)
C8	0.034 (4)	0.027 (3)	0.047 (4)	0.002 (3)	0.001 (3)	−0.004 (3)
C9	0.056 (5)	0.043 (4)	0.031 (4)	−0.006 (3)	−0.011 (3)	0.000 (3)
C10	0.053 (5)	0.029 (4)	0.033 (4)	0.002 (3)	−0.004 (3)	0.005 (3)
C11	0.038 (4)	0.040 (4)	0.045 (4)	−0.001 (3)	0.010 (3)	0.000 (3)
C12	0.036 (4)	0.037 (4)	0.034 (4)	−0.003 (3)	−0.001 (3)	−0.007 (3)
C13	0.036 (4)	0.025 (3)	0.038 (4)	−0.003 (3)	−0.002 (3)	0.000 (3)
C14	0.033 (4)	0.034 (4)	0.030 (4)	−0.003 (3)	0.001 (3)	0.002 (3)
C15	0.040 (4)	0.040 (4)	0.022 (3)	0.004 (3)	0.000 (3)	−0.004 (3)
C16	0.072 (5)	0.032 (4)	0.048 (5)	−0.010 (4)	0.002 (4)	0.005 (3)
C17	0.063 (5)	0.051 (5)	0.030 (4)	0.002 (4)	0.004 (4)	−0.014 (3)
C18	0.053 (4)	0.027 (4)	0.034 (4)	0.009 (3)	0.003 (3)	−0.004 (3)
C19	0.055 (4)	0.021 (3)	0.036 (4)	0.006 (3)	−0.002 (3)	0.003 (3)
C20	0.067 (6)	0.037 (4)	0.052 (5)	−0.003 (4)	−0.008 (4)	0.008 (4)
C21	0.167 (12)	0.046 (5)	0.047 (6)	−0.006 (6)	−0.051 (7)	0.008 (4)
C22	0.231 (18)	0.044 (6)	0.025 (5)	0.015 (8)	0.011 (8)	0.012 (4)
C23	0.147 (12)	0.062 (7)	0.065 (7)	0.016 (7)	0.052 (7)	0.016 (6)
C24	0.072 (6)	0.048 (5)	0.055 (5)	0.000 (4)	0.013 (5)	0.003 (4)

Br1—C2	1.877 (6)	C7—C12	1.389 (9)
Br2—C14	1.881 (6)	C8—C9	1.371 (10)
F1—C8	1.358 (8)	C9—C10	1.375 (10)
F2—C12	1.363 (8)	C9—H9A	0.9500
F3—C20	1.347 (9)	C10—C11	1.370 (10)
F4—C24	1.351 (10)	C10—H10A	0.9500
O1—C6	1.185 (8)	C11—C12	1.368 (9)
O2—C18	1.210 (8)	C11—H11A	0.9500
N1—C3	1.390 (8)	C13—C14	1.416 (9)
N1—N2	1.401 (7)	C13—C16	1.489 (9)
N1—C6	1.403 (8)	C14—C15	1.345 (9)
N2—C1	1.311 (8)	C15—C17	1.487 (9)
N3—N4	1.380 (7)	C16—H16A	0.9800
N3—C15	1.390 (8)	C16—H16B	0.9800
N3—C18	1.403 (8)	C16—H16C	0.9800
N4—C13	1.311 (8)	C17—H17A	0.9800
C1—C2	1.438 (9)	C17—H17B	0.9800
C1—C4	1.491 (8)	C17—H17C	0.9800
C2—C3	1.346 (9)	C18—C19	1.494 (9)
C3—C5	1.491 (8)	C19—C20	1.369 (10)
C4—H4A	0.9800	C19—C24	1.373 (11)
C4—H4B	0.9800	C20—C21	1.371 (12)
C4—H4C	0.9800	C21—C22	1.350 (16)
C5—H5A	0.9800	C21—H21A	0.9500
C5—H5B	0.9800	C22—C23	1.358 (17)
C5—H5C	0.9800	C22—H22A	0.9500
C6—C7	1.506 (8)	C23—C24	1.382 (13)
C7—C8	1.382 (9)	C23—H23A	0.9500
C3—N1—N2	112.0 (5)	C10—C11—H11A	121.4
C3—N1—C6	128.7 (5)	F2—C12—C11	119.2 (6)
N2—N1—C6	119.3 (5)	F2—C12—C7	116.7 (6)
C1—N2—N1	104.8 (5)	C11—C12—C7	124.1 (6)
N4—N3—C15	112.0 (5)	N4—C13—C14	110.5 (5)
N4—N3—C18	119.5 (5)	N4—C13—C16	121.2 (6)
C15—N3—C18	128.3 (5)	C14—C13—C16	128.3 (6)
C13—N4—N3	104.9 (5)	C15—C14—C13	108.3 (6)
N2—C1—C2	110.2 (5)	C15—C14—Br2	125.1 (5)
N2—C1—C4	120.9 (6)	C13—C14—Br2	126.6 (5)
C2—C1—C4	128.9 (6)	C14—C15—N3	104.4 (5)
C3—C2—C1	108.3 (5)	C14—C15—C17	130.6 (6)
C3—C2—Br1	125.9 (5)	N3—C15—C17	125.1 (6)
C1—C2—Br1	125.7 (5)	C13—C16—H16A	109.5
C2—C3—N1	104.7 (5)	C13—C16—H16B	109.5
C2—C3—C5	130.8 (6)	H16A—C16—H16B	109.5
N1—C3—C5	124.5 (6)	C13—C16—H16C	109.5
C1—C4—H4A	109.5	H16A—C16—H16C	109.5
C1—C4—H4B	109.5	H16B—C16—H16C	109.5
H4A—C4—H4B	109.5	C15—C17—H17A	109.5
C1—C4—H4C	109.5	C15—C17—H17B	109.5
H4A—C4—H4C	109.5	H17A—C17—H17B	109.5
H4B—C4—H4C	109.5	C15—C17—H17C	109.5
C3—C5—H5A	109.5	H17A—C17—H17C	109.5
C3—C5—H5B	109.5	H17B—C17—H17C	109.5
H5A—C5—H5B	109.5	O2—C18—N3	121.6 (6)
C3—C5—H5C	109.5	O2—C18—C19	123.0 (6)
H5A—C5—H5C	109.5	N3—C18—C19	115.4 (5)
H5B—C5—H5C	109.5	C20—C19—C24	117.6 (7)
O1—C6—N1	121.9 (6)	C20—C19—C18	121.3 (7)
O1—C6—C7	123.2 (6)	C24—C19—C18	121.0 (7)
N1—C6—C7	114.9 (5)	F3—C20—C19	117.2 (7)
C8—C7—C12	115.5 (6)	F3—C20—C21	120.6 (9)
C8—C7—C6	122.2 (6)	C19—C20—C21	122.2 (9)
C12—C7—C6	122.0 (6)	C22—C21—C20	118.1 (10)
F1—C8—C9	120.4 (6)	C22—C21—H21A	120.9
F1—C8—C7	116.8 (6)	C20—C21—H21A	120.9
C9—C8—C7	122.9 (6)	C21—C22—C23	122.5 (10)
C8—C9—C10	118.3 (7)	C21—C22—H22A	118.8
C8—C9—H9A	120.9	C23—C22—H22A	118.8
C10—C9—H9A	120.9	C22—C23—C24	118.1 (11)
C11—C10—C9	122.1 (7)	C22—C23—H23A	120.9
C11—C10—H10A	119.0	C24—C23—H23A	120.9
C9—C10—H10A	119.0	F4—C24—C19	117.4 (8)
C12—C11—C10	117.2 (7)	F4—C24—C23	121.2 (9)
C12—C11—H11A	121.4	C19—C24—C23	121.4 (10)
C3—N1—N2—C1	−1.0 (7)	C8—C7—C12—C11	1.0 (10)
C6—N1—N2—C1	177.4 (6)	C6—C7—C12—C11	175.0 (6)
C15—N3—N4—C13	0.5 (7)	N3—N4—C13—C14	−0.1 (7)
C18—N3—N4—C13	176.6 (6)	N3—N4—C13—C16	−179.4 (6)
N1—N2—C1—C2	1.1 (7)	N4—C13—C14—C15	−0.3 (8)
N1—N2—C1—C4	−179.2 (6)	C16—C13—C14—C15	178.9 (7)
N2—C1—C2—C3	−0.9 (8)	N4—C13—C14—Br2	−179.3 (5)
C4—C1—C2—C3	179.4 (7)	C16—C13—C14—Br2	−0.1 (11)
N2—C1—C2—Br1	178.8 (5)	C13—C14—C15—N3	0.6 (7)
C4—C1—C2—Br1	−0.9 (11)	Br2—C14—C15—N3	179.6 (4)
C1—C2—C3—N1	0.3 (7)	C13—C14—C15—C17	−179.6 (7)
Br1—C2—C3—N1	−179.4 (4)	Br2—C14—C15—C17	−0.6 (11)
C1—C2—C3—C5	178.5 (6)	N4—N3—C15—C14	−0.7 (7)
Br1—C2—C3—C5	−1.2 (11)	C18—N3—C15—C14	−176.4 (6)
N2—N1—C3—C2	0.4 (7)	N4—N3—C15—C17	179.5 (6)
C6—N1—C3—C2	−177.8 (6)	C18—N3—C15—C17	3.8 (11)
N2—N1—C3—C5	−177.9 (6)	N4—N3—C18—O2	−175.1 (7)
C6—N1—C3—C5	3.8 (10)	C15—N3—C18—O2	0.3 (11)
C3—N1—C6—O1	10.4 (11)	N4—N3—C18—C19	4.4 (9)
N2—N1—C6—O1	−167.7 (6)	C15—N3—C18—C19	179.8 (6)
C3—N1—C6—C7	−168.9 (6)	O2—C18—C19—C20	−103.7 (9)
N2—N1—C6—C7	13.0 (8)	N3—C18—C19—C20	76.9 (8)
O1—C6—C7—C8	67.7 (10)	O2—C18—C19—C24	72.5 (10)
N1—C6—C7—C8	−113.0 (7)	N3—C18—C19—C24	−107.0 (8)
O1—C6—C7—C12	−105.9 (8)	C24—C19—C20—F3	−178.2 (7)
N1—C6—C7—C12	73.4 (8)	C18—C19—C20—F3	−2.0 (10)
C12—C7—C8—F1	179.5 (6)	C24—C19—C20—C21	1.8 (11)
C6—C7—C8—F1	5.5 (9)	C18—C19—C20—C21	178.1 (7)
C12—C7—C8—C9	−1.1 (9)	F3—C20—C21—C22	179.0 (8)
C6—C7—C8—C9	−175.1 (6)	C19—C20—C21—C22	−1.1 (13)
F1—C8—C9—C10	−178.6 (6)	C20—C21—C22—C23	−0.2 (16)
C7—C8—C9—C10	2.0 (10)	C21—C22—C23—C24	0.6 (16)
C8—C9—C10—C11	−2.8 (10)	C20—C19—C24—F4	179.0 (7)
C9—C10—C11—C12	2.6 (10)	C18—C19—C24—F4	2.7 (11)
C10—C11—C12—F2	−179.8 (6)	C20—C19—C24—C23	−1.3 (12)
C10—C11—C12—C7	−1.7 (10)	C18—C19—C24—C23	−177.6 (8)
C8—C7—C12—F2	179.0 (6)	C22—C23—C24—F4	179.9 (9)
C6—C7—C12—F2	−7.0 (9)	C22—C23—C24—C19	0.2 (14)