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Literature DB >> 19217789

Synthesis of novel substituted pyrazole-5-carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer cells.

Liang-Wen Zheng¹, Ling-Ling Wu, Bao-Xiang Zhao, Wen-Liang Dong, Jun-Ying Miao.

Abstract

A series of novel 3-aryl-1-(4-tert-butylbenzyl)-1H-pyrazole-5-carbohydrazide hydrazone derivatives were synthesized and the effects of all the compounds on A549 cell growth were investigated. The results showed that all compounds had inhibitory effects on the growth of A549 lung cancer cells and compound (E)-1-(4-tert-butylbenzyl)-N'-(1-(5-chloro-2-hydroxyphenyl) ethylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide (3e) possessed the highest growth inhibitory effect and induced apoptosis of A549 lung cancer cells.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2009 PMID： 19217789 DOI： 10.1016/j.bmc.2009.01.037

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

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Cited

18 in total

1. The synthesis, X-ray crystal structure and optical properties of novel 5-aryl-3-ferrocenyl-1-pyridazinyl-pyrazoline derivatives.

Authors: Zhong-Liang Gong; Yong-Sheng Xie; Bao-Xiang Zhao; Hong-Shui Lv; Wei-Yong Liu; Liang-Wen Zheng; Song Lian
Journal: J Fluoresc Date: 2010-10-02 Impact factor: 2.217

Review 2. Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review.

Authors: Khalid Karrouchi; Smaail Radi; Youssef Ramli; Jamal Taoufik; Yahia N Mabkhot; Faiz A Al-Aizari; M'hammed Ansar
Journal: Molecules Date: 2018-01-12 Impact factor: 4.411

3. Key role of hydrazine to the interaction between oxaloacetic against phosphoenolpyruvic carboxykinase (PEPCK): ONIOM calculations.

Authors: Pongthep Prajongtat; Darinee Sae-Tang Phromyothin; Supa Hannongbua
Journal: J Mol Model Date: 2013-04-27 Impact factor: 1.810

4. 4-Chloro-5-[(5,5-dimethyl-4,5-dihydro-isoxazol-3-yl)sulfonyl-meth-yl]-3-methyl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazole.

Authors: Hong-Ju Ma; Qian-Fei Zhao; Xiang-Dong Mei; Jun Ning
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2009-09-30

5. Synthesis, characterization, and antibacterial and anticancer screening of {M(2+)-Co (3+)-M (2+)} and {Co (3+)-M (2+)} (M is Zn, Cd, Hg) heterometallic complexes.

Authors: Nagendra K Kaushik; Anurag Mishra; Afsar Ali; J S Adhikari; Akhilesh K Verma; Rajeev Gupta
Journal: J Biol Inorg Chem Date: 2012-09-23 Impact factor: 3.358

6. Novel ferrocenyl derivatives exert anti-cancer effect in human lung cancer cells in vitro via inducing G1-phase arrest and senescence.

Authors: Ying Li; Han-lin Ma; Lei Han; Wei-yong Liu; Bao-xiang Zhao; Shang-li Zhang; Jun-ying Miao
Journal: Acta Pharmacol Sin Date: 2013-05-06 Impact factor: 6.150

Synthesis of novel substituted pyrazole-5-carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer cells.

1. The synthesis, X-ray crystal structure and optical properties of novel 5-aryl-3-ferrocenyl-1-pyridazinyl-pyrazoline derivatives.

Review 2. Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review.

3. Key role of hydrazine to the interaction between oxaloacetic against phosphoenolpyruvic carboxykinase (PEPCK): ONIOM calculations.

4. 4-Chloro-5-[(5,5-dimethyl-4,5-dihydro-isoxazol-3-yl)sulfonyl-meth-yl]-3-methyl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazole.

5. Synthesis, characterization, and antibacterial and anticancer screening of {M(2+)-Co (3+)-M (2+)} and {Co (3+)-M (2+)} (M is Zn, Cd, Hg) heterometallic complexes.

6. Novel ferrocenyl derivatives exert anti-cancer effect in human lung cancer cells in vitro via inducing G1-phase arrest and senescence.

7. (4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)(2,6-difluoro-phen-yl)methanone.

8. N'-(Adamantan-2-yl-idene)benzo-hydrazide.

9. Pyrazole carbohydrazide derivatives of pharmaceutical interest.

Review 10. A review exploring biological activities of hydrazones.