Literature DB >> 2157892

Simian virus 40 large T-antigen-dependent DNA replication is activated by protein phosphatase 2A in vitro.

R Lawson1, P Cohen, D P Lane.   

Abstract

The simian virus 40 large T antigen (T) is a multifunctional phosphoprotein. We found that T-dependent simian virus 40 DNA replication is substantially inhibited by okadaic acid. This result suggests that DNA replication is activated by dephosphorylation in vitro. We show here that the target activated by dephosphorylation, which stimulates DNA replication, is T and that the phosphatase involved is protein phosphatase 2A.

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Year:  1990        PMID： 2157892      PMCID： PMC249399          DOI： 10.1128/JVI.64.5.2380-2383.1990

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  31 in total

1.  Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen.

Authors:  P J Mitchell; C Wang; R Tjian
Journal:  Cell       Date:  1987-09-11       Impact factor: 41.582

2.  Simian virus 40 large T antigen DNA helicase. Characterization of the ATPase-dependent DNA unwinding activity and its substrate requirements.

Authors:  M Wiekowski; M W Schwarz; H Stahl
Journal:  J Biol Chem       Date:  1988-01-05       Impact factor: 5.157

3.  Removal of serine phosphates from simian virus 40 large T antigen increases its ability to stimulate DNA replication in vitro but has no effect on ATPase and DNA binding.

Authors:  F A Grässer; K Mann; G Walter
Journal:  J Virol       Date:  1987-11       Impact factor: 5.103

4.  An immunoaffinity purification procedure for SV40 large T antigen.

Authors:  V Simanis; D P Lane
Journal:  Virology       Date:  1985-07-15       Impact factor: 3.616

5.  T-antigen-DNA polymerase alpha complex implicated in simian virus 40 DNA replication.

Authors:  S T Smale; R Tjian
Journal:  Mol Cell Biol       Date:  1986-11       Impact factor: 4.272

6.  p53 and DNA polymerase alpha compete for binding to SV40 T antigen.

Authors:  J V Gannon; D P Lane
Journal:  Nature       Date:  1987 Oct 1-7       Impact factor: 49.962

7.  Improved localization of phosphorylation sites in simian virus 40 large T antigen.

Authors:  F van Roy; L Fransen; W Fiers
Journal:  J Virol       Date:  1983-01       Impact factor: 5.103

8.  Initiation of simian virus 40 DNA replication in vitro: large-tumor-antigen- and origin-dependent unwinding of the template.

Authors:  M S Wold; J J Li; T J Kelly
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

9.  The simian virus 40 large T antigen. A lot packed into a little.

Authors:  D M Livingston; M K Bradley
Journal:  Mol Biol Med       Date:  1987-04

10.  Essential contact residues within SV40 large T antigen binding sites I and II identified by alkylation-interference.

Authors:  K A Jones; R Tjian
Journal:  Cell       Date:  1984-01       Impact factor: 41.582
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  13 in total

1.  Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A.

Authors:  D M Virshup; A A Russo; T J Kelly
Journal:  Mol Cell Biol       Date:  1992-11       Impact factor: 4.272

Review 2.  Nuclear protein phosphorylation and growth control.

Authors:  D W Meek; A J Street
Journal:  Biochem J       Date:  1992-10-01       Impact factor: 3.857

3.  Phenotype-specific phosphorylation of simian virus 40 tsA mutant large T antigens in tsA N-type and A-type transformants.

Authors:  U Knippschild; J Kiefer; T Patschinsky; W Deppert
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

4.  Protein phosphatase 2A dephosphorylates simian virus 40 large T antigen specifically at residues involved in regulation of DNA-binding activity.

Authors:  K H Scheidtmann; D M Virshup; T J Kelly
Journal:  J Virol       Date:  1991-04       Impact factor: 5.103

5.  Two regions of simian virus 40 T antigen determine cooperativity of double-hexamer assembly on the viral origin of DNA replication and promote hexamer interactions during bidirectional origin DNA unwinding.

Authors:  K Weisshart; P Taneja; A Jenne; U Herbig; D T Simmons; E Fanning
Journal:  J Virol       Date:  1999-03       Impact factor: 5.103

6.  Protein phosphatase 2A in Saccharomyces cerevisiae: effects on cell growth and bud morphogenesis.

Authors:  H Ronne; M Carlberg; G Z Hu; J O Nehlin
Journal:  Mol Cell Biol       Date:  1991-10       Impact factor: 4.272

7.  Simian virus 40 small-t antigen stimulates viral DNA replication in permissive monkey cells.

Authors:  C Cicala; M L Avantaggiati; A Graessmann; K Rundell; A S Levine; M Carbone
Journal:  J Virol       Date:  1994-05       Impact factor: 5.103

8.  Polyomavirus large and small T antigens cooperate in induction of the S phase in serum-starved 3T3 mouse fibroblasts.

Authors:  E Ogris; I Mudrak; E Wintersberger
Journal:  J Virol       Date:  1992-01       Impact factor: 5.103

9.  A novel translational regulation function for the simian virus 40 large-T antigen gene.

Authors:  P Rajan; S Swaminathan; J Zhu; C N Cole; G Barber; M J Tevethia; B Thimmapaya
Journal:  J Virol       Date:  1995-02       Impact factor: 5.103

10.  Involvement of simian virus 40 (SV40) small t antigen in trans activation of SV40 early and late promoters.

Authors:  I Bikel; M R Loeken
Journal:  J Virol       Date:  1992-03       Impact factor: 5.103
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