Literature DB >> 3041175

The simian virus 40 large T antigen. A lot packed into a little.

D M Livingston, M K Bradley.   

Abstract

Simian virus 40 (SV40) large T antigen is an 81,000 Mr, multifunctional viral phosphoprotein. Certain of its functions are essential to the viral replication process in monkey cells. Others, as yet undefined in biochemical terms, contribute to its neoplastic transforming activity. This review focuses on the known structure-function relationships of this protein and reflects upon the potential significance of its transforming properties in the natural host species of this virus.

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Year:  1987        PMID： 3041175

Source DB:  PubMed          Journal:  Mol Biol Med        ISSN： 0735-1313


  46 in total

Review 1.  Nuclear protein phosphorylation and growth control.

Authors:  D W Meek; A J Street
Journal:  Biochem J       Date:  1992-10-01       Impact factor: 3.857

2.  Selective amplification of periportal transitional cells precedes formation of hepatocellular carcinoma in SV40 large tag transgenic mice.

Authors:  P Schirmacher; W A Held; D Yang; L Biempica; C E Rogler
Journal:  Am J Pathol       Date:  1991-07       Impact factor: 4.307

3.  Phenotype-specific phosphorylation of simian virus 40 tsA mutant large T antigens in tsA N-type and A-type transformants.

Authors:  U Knippschild; J Kiefer; T Patschinsky; W Deppert
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

4.  Simian virus 40 (SV40) T-antigen transcriptional activation mediated through the Oct/SPH region of the SV40 late promoter.

Authors:  M C Gruda; J C Alwine
Journal:  J Virol       Date:  1991-07       Impact factor: 5.103

5.  Genetic evidence that acute morphologic transformation, induction of cellular DNA synthesis, and focus formation are mediated by a single activity of the bovine papillomavirus E5 protein.

Authors:  J Settleman; A Fazeli; J Malicki; B H Horwitz; D DiMaio
Journal:  Mol Cell Biol       Date:  1989-12       Impact factor: 4.272

6.  Hierarchy among multiple H-2b-restricted cytotoxic T-lymphocyte epitopes within simian virus 40 T antigen.

Authors:  L M Mylin; R H Bonneau; J D Lippolis; S S Tevethia
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

7.  Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1.

Authors:  F Wang; S F Tsang; M G Kurilla; J I Cohen; E Kieff
Journal:  J Virol       Date:  1990-07       Impact factor: 5.103

8.  Human papillomavirus type 16 nucleoprotein E7 is a tumor rejection antigen.

Authors:  L P Chen; E K Thomas; S L Hu; I Hellström; K E Hellström
Journal:  Proc Natl Acad Sci U S A       Date:  1991-01-01       Impact factor: 11.205

9.  Extended life span of human endometrial stromal cells transfected with cloned origin-defective, temperature-sensitive simian virus 40.

Authors:  C A Rinehart; J S Haskill; J S Morris; T D Butler; D G Kaufman
Journal:  J Virol       Date:  1991-03       Impact factor: 5.103

10.  BK virus large T antigen: interactions with the retinoblastoma family of tumor suppressor proteins and effects on cellular growth control.

Authors:  K F Harris; J B Christensen; M J Imperiale
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103
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