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Literature DB >> 21576447

SugE, a new member of the SMR family of transporters, contributes to antimicrobial resistance in Enterobacter cloacae.

Gui-Xin He¹, Chu Zhang, Robert R Crow, Conner Thorpe, Huizhong Chen, Sanath Kumar, Tomofusa Tsuchiya, Manuel F Varela.

Abstract

We cloned a gene, sugE, from the chromosome of Enterobacter cloacae ATCC 13047. Analysis of the susceptibilities of the sugE-containing strain (Escherichia coli KAM32/pSUGE28) and sugE-deficient E. cloacae (EcΔsugE) showed that SugE confers resistance to cetyltrimethylammonium bromide, cetylpyridinium chloride, tetraphenylphosphonium, benzalkonium chloride, ethidium bromide, and sodium dodecyl sulfate. We also investigated expression of sugE. We confirm here that SugE from E. cloacae is an SMR family transporter as determined by observing its energy-dependent drug efflux activity.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2011 PMID： 21576447 PMCID： PMC3147620 DOI： 10.1128/AAC.00094-11

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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