Literature DB >> 15956430

Gene mutations responsible for overexpression of AmpC beta-lactamase in some clinical isolates of Enterobacter cloacae.

Kenichi Kaneko1, Ryoichi Okamoto, Ryuichi Nakano, Sayoko Kawakami, Matsuhisa Inoue.   

Abstract

AmpC regulatory genes in 21 ceftazidime-resistant clinical isolates of Enterobacter cloacae (MICs of > or = 16 microg/ml) were characterized. All isolates exhibited AmpC overproduction due to AmpD mutation. Additionally, we found two AmpR mutants among the isolates. This is the first report of chromosomal ampR mutation in clinical isolates of E. cloacae.

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Year:  2005        PMID： 15956430      PMCID： PMC1151923          DOI： 10.1128/JCM.43.6.2955-2958.2005

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  32 in total

1.  Binding of the Citrobacter freundii AmpR regulator to a single DNA site provides both autoregulation and activation of the inducible ampC beta-lactamase gene.

Authors:  S Lindquist; F Lindberg; S Normark
Journal:  J Bacteriol       Date:  1989-07       Impact factor: 3.490

Review 2.  Regulation of inducible AmpC beta-lactamase expression among Enterobacteriaceae.

Authors:  N D Hanson; C C Sanders
Journal:  Curr Pharm Des       Date:  1999-11       Impact factor: 3.116

Review 3.  A functional classification scheme for beta-lactamases and its correlation with molecular structure.

Authors:  K Bush; G A Jacoby; A A Medeiros
Journal:  Antimicrob Agents Chemother       Date:  1995-06       Impact factor: 5.191

Review 4.  Why does Escherichia coli recycle its cell wall peptides?

Authors:  J T Park
Journal:  Mol Microbiol       Date:  1995-08       Impact factor: 3.501

5.  Interactions of wild-type and mutant AmpR of Citrobacter freundii with target DNA.

Authors:  E Bartowsky; S Normark
Journal:  Mol Microbiol       Date:  1993-11       Impact factor: 3.501

6.  Purification and mutant analysis of Citrobacter freundii AmpR, the regulator for chromosomal AmpC beta-lactamase.

Authors:  E Bartowsky; S Normark
Journal:  Mol Microbiol       Date:  1991-07       Impact factor: 3.501

7.  Sequences of wild-type and mutant ampD genes of Citrobacter freundii and Enterobacter cloacae.

Authors:  U Kopp; B Wiedemann; S Lindquist; S Normark
Journal:  Antimicrob Agents Chemother       Date:  1993-02       Impact factor: 5.191

8.  ampG is essential for high-level expression of AmpC beta-lactamase in Enterobacter cloacae.

Authors:  G Korfmann; C C Sanders
Journal:  Antimicrob Agents Chemother       Date:  1989-11       Impact factor: 5.191

9.  AmpD, essential for both beta-lactamase regulation and cell wall recycling, is a novel cytosolic N-acetylmuramyl-L-alanine amidase.

Authors:  C Jacobs; B Joris; M Jamin; K Klarsov; J Van Beeumen; D Mengin-Lecreulx; J van Heijenoort; J T Park; S Normark; J M Frère
Journal:  Mol Microbiol       Date:  1995-02       Impact factor: 3.501

10.  Bacterial cell wall recycling provides cytosolic muropeptides as effectors for beta-lactamase induction.

Authors:  C Jacobs; L J Huang; E Bartowsky; S Normark; J T Park
Journal:  EMBO J       Date:  1994-10-03       Impact factor: 11.598
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  28 in total

1.  In vivo reversion to the wild-type beta-lactam resistance phenotype mediated by a plasmid carrying ampR and qnrA1 in Enterobacter cloacae.

Authors:  J J González-López; M Sabaté; S Lavilla; M N Larrosa; R M Bartolomé; G Prats
Journal:  Antimicrob Agents Chemother       Date:  2006-09       Impact factor: 5.191

2.  Model system to evaluate the effect of ampD mutations on AmpC-mediated beta-lactam resistance.

Authors:  Amber J Schmidtke; Nancy D Hanson
Journal:  Antimicrob Agents Chemother       Date:  2006-06       Impact factor: 5.191

Review 3.  A Primer on AmpC β-Lactamases: Necessary Knowledge for an Increasingly Multidrug-resistant World.

Authors:  Pranita D Tamma; Yohei Doi; Robert A Bonomo; J Kristie Johnson; Patricia J Simner
Journal:  Clin Infect Dis       Date:  2019-09-27       Impact factor: 9.079

4.  Strong Environment-Genotype Interactions Determine the Fitness Costs of Antibiotic Resistance In Vitro and in an Insect Model of Infection.

Authors:  C James Manktelow; Elitsa Penkova; Lucy Scott; Andrew C Matthews; Ben Raymond
Journal:  Antimicrob Agents Chemother       Date:  2020-09-21       Impact factor: 5.191

5.  SugE, a new member of the SMR family of transporters, contributes to antimicrobial resistance in Enterobacter cloacae.

Authors:  Gui-Xin He; Chu Zhang; Robert R Crow; Conner Thorpe; Huizhong Chen; Sanath Kumar; Tomofusa Tsuchiya; Manuel F Varela
Journal:  Antimicrob Agents Chemother       Date:  2011-05-16       Impact factor: 5.191

6.  Complex Regulation Pathways of AmpC-Mediated β-Lactam Resistance in Enterobacter cloacae Complex.

Authors:  François Guérin; Christophe Isnard; Vincent Cattoir; Jean Christophe Giard
Journal:  Antimicrob Agents Chemother       Date:  2015-10-05       Impact factor: 5.191

7.  EmmdR, a new member of the MATE family of multidrug transporters, extrudes quinolones from Enterobacter cloacae.

Authors:  Gui-Xin He; Conner Thorpe; Dennis Walsh; Robert Crow; Huizhong Chen; Sanath Kumar; Manuel F Varela
Journal:  Arch Microbiol       Date:  2011-08-07       Impact factor: 2.552

8.  The β-lactamase gene regulator AmpR is a tetramer that recognizes and binds the D-Ala-D-Ala motif of its repressor UDP-N-acetylmuramic acid (MurNAc)-pentapeptide.

Authors:  Grishma Vadlamani; Misty D Thomas; Trushar R Patel; Lynda J Donald; Thomas M Reeve; Jörg Stetefeld; Kenneth G Standing; David J Vocadlo; Brian L Mark
Journal:  J Biol Chem       Date:  2014-12-05       Impact factor: 5.157

9.  Inactivation of the glycoside hydrolase NagZ attenuates antipseudomonal beta-lactam resistance in Pseudomonas aeruginosa.

Authors:  Azizah Asgarali; Keith A Stubbs; Antonio Oliver; David J Vocadlo; Brian L Mark
Journal:  Antimicrob Agents Chemother       Date:  2009-03-09       Impact factor: 5.191

10.  Characterisation and clinical features of Enterobacter cloacae bloodstream infections occurring at a tertiary care university hospital in Switzerland: is cefepime adequate therapy?

Authors:  Markus Hilty; Parham Sendi; Salome N Seiffert; Sara Droz; Vincent Perreten; Andrea M Hujer; Robert A Bonomo; Kathrin Mühlemann; Andrea Endimiani
Journal:  Int J Antimicrob Agents       Date:  2013-01-10       Impact factor: 5.283
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