Literature DB >> 21574914

Polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase: a novel biotechnology-based blood substitute that transports both oxygen and carbon dioxide and also acts as an antioxidant.

Yuzhu Bian1, Zhixia Rong, Thomas Ming Swi Chang.   

Abstract

Polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase (PolyHb-SOD-CAT-CA) is a therapeutic antioxidant that also transports both oxygen and carbon dioxide. This is formed by crosslinking Hb with SOD, CAT, and CA using glutaraldehyde. Crosslinking stroma free Hb from red blood cell (rbc) reduces CA activity to 55%. Addition of more CA resulted in a preparation with the same CA activity as RBC. PolyHb in the complex acts as a buffer to prevent large pH changes as carbon dioxide is converted to carbonic acid. We then prepare and optimize a novel PolyHb-SOD-CAT-CA, a therapeutic antioxidant that also transports both oxygen and carbon dioxide.

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Year:  2011        PMID： 21574914      PMCID： PMC3584015          DOI： 10.3109/10731199.2011.581052

Source DB:  PubMed          Journal:  Artif Cells Blood Substit Immobil Biotechnol        ISSN： 1073-1199


  12 in total

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Journal:  Artif Cells Blood Substit Immobil Biotechnol       Date:  2010-04

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Journal:  Physiol Rev       Date:  2000-04       Impact factor: 37.312

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Journal:  J Am Coll Surg       Date:  2002-10       Impact factor: 6.113

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Journal:  J Thorac Cardiovasc Surg       Date:  2002-07       Impact factor: 5.209

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Journal:  Nat Biotechnol       Date:  1998-07       Impact factor: 54.908
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  9 in total

Review 1.  From artificial red blood cells, oxygen carriers, and oxygen therapeutics to artificial cells, nanomedicine, and beyond.

Authors:  Thomas M S Chang
Journal:  Artif Cells Blood Substit Immobil Biotechnol       Date:  2012-03-13

2.  Acute kidney function and morphology following topload administration of recombinant hemoglobin solution.

Authors:  Alexandre Fabricio Martucci; Ana Carolina Carvalho Ferreira Abreu Martucci; Pedro Cabrales; Paulo do Nascimento; Marcos Intaglietta; Amy G Tsai; Yara Marcondes Machado Castiglia
Journal:  Artif Cells Nanomed Biotechnol       Date:  2016-10-31       Impact factor: 5.678

Review 3.  Emerging trends in environmental and industrial applications of marine carbonic anhydrase: a review.

Authors:  Sudabeh Iraninasab; Sana Sharifian; Ahmad Homaei; Mozafar Bagherzadeh Homaee; Tanvi Sharma; Ashok Kumar Nadda; John F Kennedy; Muhammad Bilal; Hafiz M N Iqbal
Journal:  Bioprocess Biosyst Eng       Date:  2021-11-25       Impact factor: 3.210

4.  Novel Nanodimension artificial red blood cells that act as O2 and CO2 carrier with enhanced antioxidant activity: PLA-PEG nanoencapsulated PolySFHb-superoxide dismutase-catalase-carbonic anhydrase.

Authors:  Wei Gao; Yuzhu Bian; Thomas M S Chang
Journal:  Artif Cells Nanomed Biotechnol       Date:  2013-01-22       Impact factor: 5.678

5.  Lowering of elevated tissue PCO2 in a hemorrhagic shock rat model after reinfusion of a novel nanobiotechnological polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase that is an oxygen and a carbon dioxide carrier with enhanced antioxidant properties.

Authors:  Yuzhu Bian; Gao Wei; Thomas M S Chang
Journal:  Artif Cells Nanomed Biotechnol       Date:  2013-02       Impact factor: 5.678

6.  A novel nanobiotherapeutic poly-[hemoglobin-superoxide dismutase-catalase-carbonic anhydrase] with no cardiac toxicity for the resuscitation of a rat model with 90 minutes of sustained severe hemorrhagic shock with loss of 2/3 blood volume.

Authors:  Yuzhu Bian; Thomas Ming Swi Chang
Journal:  Artif Cells Nanomed Biotechnol       Date:  2014-10-09       Impact factor: 5.678

7.  Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity.

Authors:  Vlad Al Toma; Anca D Farcaș; Ioana Roman; Bogdan Sevastre; Denisa Hathazi; Florina Scurtu; Grigore Damian; Radu Silaghi-Dumitrescu
Journal:  PLoS One       Date:  2016-04-20       Impact factor: 3.240

Review 8.  Microbial Carbonic Anhydrases in Biomimetic Carbon Sequestration for Mitigating Global Warming: Prospects and Perspectives.

Authors:  Himadri Bose; Tulasi Satyanarayana
Journal:  Front Microbiol       Date:  2017-08-25       Impact factor: 5.640

9.  Glutaraldehyde-Polymerized Hemoglobin: In Search of Improved Performance as Oxygen Carrier in Hemorrhage Models.

Authors:  Anca D Farcas; Vlad Al Toma; Ioana Roman; Bogdan Sevastre; Florina Scurtu; Radu Silaghi-Dumitrescu
Journal:  Bioinorg Chem Appl       Date:  2020-09-01       Impact factor: 7.778
  9 in total

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