Literature DB >> 21572560

Synthesis and sensing of bisphosphonophosphate alkyl monoesters: A novel class of compounds for the study of nucleoside 5'-triphosphate chemistry.

Brian T Chamberlain1, Jorge Osuna, Boris A Kashemirov, Charles E McKenna.   

Abstract

A series of novel β,γ-methylene-, monofluoromethylene-, and difluoromethylene-bisphosphonophosphate alkyl monoesters was synthesized. The compounds were conveniently detected during preparative HPLC using post-column derivatization with a phosphate-specific chemosensor.

Entities:  

Year:  2011        PMID： 21572560      PMCID： PMC3091817          DOI： 10.1080/10426507.2010.526675

Source DB:  PubMed          Journal:  Phosphorus Sulfur Silicon Relat Elem        ISSN： 1026-7719


  6 in total

1.  First artificial receptors and chemosensors toward phosphorylated peptide in aqueous solution.

Authors:  Akio Ojida; Yasuko Mito-Oka; Masa-Aki Inoue; Itaru Hamachi
Journal:  J Am Chem Soc       Date:  2002-06-05       Impact factor: 15.419

2.  Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta.

Authors:  Christopher A Sucato; Thomas G Upton; Boris A Kashemirov; Vinod K Batra; Václav Martínek; Yun Xiang; William A Beard; Lars C Pedersen; Samuel H Wilson; Charles E McKenna; Jan Florián; Arieh Warshel; Myron F Goodman
Journal:  Biochemistry       Date:  2007-01-16       Impact factor: 3.162

3.  An improved method for the synthesis of nucleoside triphosphate analogues.

Authors:  Samy Mohamady; David L Jakeman
Journal:  J Org Chem       Date:  2005-12-09       Impact factor: 4.354

4.  (R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta.

Authors:  Charles E McKenna; Boris A Kashemirov; Thomas G Upton; Vinod K Batra; Myron F Goodman; Lars C Pedersen; William A Beard; Samuel H Wilson
Journal:  J Am Chem Soc       Date:  2007-11-22       Impact factor: 15.419

5.  Halogenated beta,gamma-methylene- and ethylidene-dGTP-DNA ternary complexes with DNA polymerase beta: structural evidence for stereospecific binding of the fluoromethylene analogues.

Authors:  Vinod K Batra; Lars C Pedersen; William A Beard; Samuel H Wilson; Boris A Kashemirov; Thomas G Upton; Myron F Goodman; Charles E McKenna
Journal:  J Am Chem Soc       Date:  2010-06-09       Impact factor: 15.419

6.  DNA polymerase beta fidelity: halomethylene-modified leaving groups in pre-steady-state kinetic analysis reveal differences at the chemical transition state.

Authors:  Christopher A Sucato; Thomas G Upton; Boris A Kashemirov; Jorge Osuna; Keriann Oertell; William A Beard; Samuel H Wilson; Jan Florián; Arieh Warshel; Charles E McKenna; Myron F Goodman
Journal:  Biochemistry       Date:  2007-12-28       Impact factor: 3.162
  6 in total

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