Literature DB >> 21572432

Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification.

Paramita Chakrabarty1, Carolina Ceballos-Diaz, Wen-Lang Lin, Amanda Beccard, Karen Jansen-West, Nikolaus R McFarland, Christopher Janus, Dennis Dickson, Pritam Das, Todd E Golde.   

Abstract

We found that CNS-directed expression of interferon-γ (IFN-γ) resulted in basal ganglia calcification, reminiscent of human idiopathic basal ganglia calcification (IBGC), and nigrostriatal degeneration. Our results indicate that IFN-γ mediates age-progressive nigrostriatal degeneration in the absence of exogenous stressors. Further study of this model may provide insight into selective nigrostriatal degeneration in human IBGC and other Parkinson syndromes.

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Year:  2011        PMID： 21572432      PMCID： PMC3780582          DOI： 10.1038/nn.2829

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  15 in total

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Review 9.  Interferon-gamma: an overview of signals, mechanisms and functions.

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10.  Ifngr1 and Stat1 mediated canonical Ifn-γ signaling drives nigrostriatal degeneration.

Authors:  Michael R Strickland; Emily J Koller; Doris Z Deng; Carolina Ceballos-Diaz; Todd E Golde; Paramita Chakrabarty
Journal:  Neurobiol Dis       Date:  2017-11-28       Impact factor: 5.996
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