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Literature DB >> 215722

Effects of antidepressant agents on the synthesis of brain monoamines.

Abstract

The effect of seventeen established or possible antidepressant agents on the synthesis of 5-HT, noradrenaline and dopamine in rat brain has been investigated by measuring the accumulation of 5-hydroxytryptophan and DOPA induced by an inhibitor of the aromatic L-aminoacid decarboxylase (3-hydroxybenzylhydrazine hydrochloride, 100 mg/kg i.p.). All the established inhibitors of 5-HT, noradrenaline and dopamine uptake were found to inhibit the synthesis of the respective monoamines, presumably by influencing a receptor-mediated feedback mechanism. A close correlation appears to exist between blockade of transmitter uptake and inhibition of transmitter synthesis. The results support current ideas on the mode of action of antidepressant agents.

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Year: 1978 PMID： 215722 DOI： 10.1007/bf01579067

Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575

30 in total

1. Tricyclic antidepressants: effects on the firing rate of brain noradrenergic neurons.

Authors: H V Nybäck; J R Walters; G K Aghajanian; R H Roth
Journal: Eur J Pharmacol Date: 1975 Jun-Jul Impact factor: 4.432

2. On the mechanism of 5-hydroxytryptamine release by thymoleptics.

Authors: A Carlsson; J Jonason; M Lindqvist
Journal: J Pharm Pharmacol Date: 1969-11 Impact factor: 3.765

3. Effects of L-tryptophan on motor activity in mice.

Authors: K Modigh
Journal: Psychopharmacologia Date: 1973-05-21

4. A comparison of the inhibitory activities of iprindole and imipramine on the uptake of 5-hydroxytryptamine and noradrenaline in brain slices.

Authors: S B Ross; A L Renyi; S O Ogren
Journal: Life Sci I Date: 1971-11-15

5. Blockade of noradrenaline uptake by 34276-Ba, a new antidepressant drug.

Authors: L Maître; M Staehelin; H J Bein
Journal: Biochem Pharmacol Date: 1971-09 Impact factor: 5.858

6. Brain histamine receptors as targets for antidepressant drugs.

Authors: P D Kanof; P Greengard
Journal: Nature Date: 1978-03-23 Impact factor: 49.962

7. Letter: Effect of chlorimipramine on the rate of tryptophan hydroxylation in the intact and transected spinal cord.

Authors: K Modigh
Journal: J Pharm Pharmacol Date: 1973-11 Impact factor: 3.765

8. Effect of ethanol on the hydroxylation of tyrosine and tryptophan in rat brain in vivo.

Authors: A Carlsson; M Lindqvist
Journal: J Pharm Pharmacol Date: 1973-06 Impact factor: 3.765

9. The effect of nomifensine on the depletion of brain serotonin and catecholamines induced respectively by fenfluramine and 6-hydroxydopamine in rats.

Authors: R Samanin; S Bernasconi; S Garattini
Journal: Eur J Pharmacol Date: 1975-12 Impact factor: 4.432

Review 10. The contribution of drug research to investigating the nature of endogenous depression.

Authors: A Carlsson
Journal: Pharmakopsychiatr Neuropsychopharmakol Date: 1976-01

35 in total

1. Effects of chlorimipramine on the synthesis and metabolism of dopamine in the rat striatum.

Authors: S A Persson
Journal: Psychopharmacology (Berl) Date: 1979 Impact factor: 4.530

2. Ex vivo inhibitory effect of the 5-HT uptake blocker citalopram on 5-HT synthesis.

Authors: C Moret; M Briley
Journal: J Neural Transm (Vienna) Date: 1997 Impact factor: 3.575

Review 3. Antidepressants and serotonergic neurotransmission: an integrative review.

Authors: P Willner
Journal: Psychopharmacology (Berl) Date: 1985 Impact factor: 4.530

4. Comparison of the effects of eleven histamine H1-receptor antagonists on monoamine turnover in the mouse brain.

Authors: R Oishi; S Shishido; M Yamori; K Saeki
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1994-02 Impact factor: 3.000

5. The effects of GBR 12909, a dopamine re-uptake inhibitor, on monoaminergic neurotransmission in rat striatum, limbic forebrain, cortical hemispheres and substantia nigra.

Authors: H Nissbrandt; G Engberg; E Pileblad
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1991-07 Impact factor: 3.000

6. Effects of acute and chronic treatment with imipramine on 5-hydroxytryptamine nerve cell groups and on bulbospinal 5-hydroxytryptamine/substance P/thyrotropin releasing hormone immunoreactive neurons in the rat. A morphometric and microdensitometric analysis.

Authors: I Kitayama; A M Janson; K Fuxe; L F Agnati; A Cintra; S O Ogren; A Härfstrand; P Eneroth; T Tsutsumi; G Jonsson
Journal: J Neural Transm Date: 1987 Impact factor: 3.575

7. Stimulation of catecholamine synthesis via activation of p44/42 MAPK in cultured bovine adrenal medullary cells by milnacipran.

Authors: Koji Shinkai; Yumiko Toyohira; Reiji Yoshimura; Masato Tsutsui; Susume Ueno; Jun Nakamura; Nobuyuki Yanagihara
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2007-01-09 Impact factor: 3.000