Samantha M Kimball1, Jodie M Burton, Paul G O'Connor, Reinhold Vieth. 1. University of Toronto, Department of Nutritional Sciences and Mount Sinai Hospital, Department of Pathology & Laboratory Medicine, Toronto, ON, Canada M5G 1X5. samantha.kimball@utoronto.ca
Abstract
OBJECTIVE: To characterize the effect of vitamin D(3) intake on urinary calcium:creatinine ratios across predefined ranges of serum 25(OH)D. DESIGN: Patients with multiple sclerosis (n=25) received escalating doses of vitamin D(3) (4000-40,000IU/d) with calcium (1200mg/d). RESULTS: Urinary calcium:creatinine was driven by increased 25(OH)D when concentrations were <75nmol/L (r=0.424, p=0.009) and >200nmol/L (r=0.281, p=0.01), but no relationship existed when 25(OH)D concentrations were 76-200nmol/L. CONCLUSIONS: A "safe", physiological range of 25(OH)D concentrations is 75-200nmol/L.
OBJECTIVE: To characterize the effect of vitamin D(3) intake on urinary calcium:creatinine ratios across predefined ranges of serum 25(OH)D. DESIGN:Patients with multiple sclerosis (n=25) received escalating doses of vitamin D(3) (4000-40,000IU/d) with calcium (1200mg/d). RESULTS: Urinary calcium:creatinine was driven by increased 25(OH)D when concentrations were <75nmol/L (r=0.424, p=0.009) and >200nmol/L (r=0.281, p=0.01), but no relationship existed when 25(OH)D concentrations were 76-200nmol/L. CONCLUSIONS: A "safe", physiological range of 25(OH)D concentrations is 75-200nmol/L.
Authors: V Carnevale; M Inglese; M A Annese; A De Matthaeis; S A Santini; V Frusciante; A Fontana; M Copetti; F Pellegrini; G D'Amico Journal: J Endocrinol Invest Date: 2012-01-30 Impact factor: 4.256