| Literature DB >> 21569850 |
Xingqun Liang1, Mi-Ryoung Song, ZengGuang Xu, Guillermo M Lanuza, Yali Liu, Tao Zhuang, Yihan Chen, Samuel L Pfaff, Sylvia M Evans, Yunfu Sun.
Abstract
The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in multiple organs and plays essential roles during embryogenesis. Isl1 is required for the survival and specification of spinal cord motor neurons. Due to early embryonic lethality and loss of motor neurons, the role of Isl1 in other aspects of motor neuron development remains unclear. In this study, we generated Isl1 mutant mouse lines expressing graded doses of Isl1. Our study has revealed essential roles of Isl1 in multiple aspects of motor neuron development, including motor neuron cell body localization, motor column formation and axon growth. In addition, Isl1 is required for survival of cranial ganglia neurons.Entities:
Mesh：
Substances：
Year: 2011 PMID： 21569850 PMCID： PMC3200226 DOI： 10.1016/j.mcn.2011.04.007
Source DB: PubMed Journal: Mol Cell Neurosci ISSN： 1044-7431 Impact factor: 4.314