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Literature DB >> 2156493

Effects of DNA-binding drugs on T4 DNA ligase.

A Montecucco¹, G Pedrali-Noy, S Spadari, M Lestingi, G Ciarrocchi.

Abstract

A number of DNA intercalating and externally binding drugs have been found to inhibit nick sealing, cohesive and blunt end ligation, AMP-dependent DNA topoisomerization and EDTA-induced DNA nicking mediated by bacteriophage T4 DNA ligase. The inhibition seems to arise from drug-substrate interaction so that formation of active DNA-Mg2(+)-AMP-enzyme complex is impaired while assembled and active complexes are not disturbed by drug binding to the substrate.

Entities: Chemical Species

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Year: 1990 PMID： 2156493 PMCID： PMC1131142 DOI： 10.1042/bj2660379

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

18 in total

1. Conformational fluctuations of DNA helix.

Authors: D E Depew; J C Wang
Journal: Proc Natl Acad Sci U S A Date: 1975-11 Impact factor: 11.205

2. Enzymatic joining of polynucleotides. XI. Reversal of Escherichia coli deoxyribonucleic acid ligase reaction.

Authors: P Modrich; I R Lehman; J C Wang
Journal: J Biol Chem Date: 1972-10-10 Impact factor: 5.157

Review 3. DNA ligase: structure, mechanism, and function.

Authors: I R Lehman
Journal: Science Date: 1974-11-29 Impact factor: 47.728

4. Purification and properties of a polynucleotide ligase from human cell cultures.

Authors: S Spadari; G Ciarrocchi; A Falaschi
Journal: Eur J Biochem Date: 1971-09-13

5. Enzymatic breakage and joining of deoxyribonucleic acid. II. The structural gene for polynucleotide ligase in bacteriophage T4.

Authors: G C Fareed; C C Richardson
Journal: Proc Natl Acad Sci U S A Date: 1967-08 Impact factor: 11.205

6. The appearance of DNA breakage and repair activities in the synchronous meiotic cycle of Lilium.

Authors: S H Howell; H Stern
Journal: J Mol Biol Date: 1971-02-14 Impact factor: 5.469

7. Multiple roles of DNA ligase at the replication fork.

Authors: A Montecucco; G Pedrali-Noy; S Spadari; G Ciarrocchi
Journal: Biochim Biophys Acta Date: 1988-12-20

Review 8. DNA ligases of eukaryotes.

Authors: S Söderhäll; T Lindahl
Journal: FEBS Lett Date: 1976-08-01 Impact factor: 4.124

9. Enzymatic characterization of a mutant of Escherichia coli with an altered DNA ligase.

Authors: P Modrich; I R Lehman
Journal: Proc Natl Acad Sci U S A Date: 1971-05 Impact factor: 11.205

10. The effect of antibiotics on the T4 polynucleotide ligase catalyzed template dependent polymerization of oligodeoxythymidylates.

Authors: B W Kalisch; J H van de Sande
Journal: Nucleic Acids Res Date: 1979 Impact factor: 16.971

5 in total

1. Evidence for cross-linking DNA by bis-intercalators with rigid and extended linkers is provided by knotting and catenation.

Authors: N K Annan; P R Cook; S T Mullins; G Lowe
Journal: Nucleic Acids Res Date: 1992-03-11 Impact factor: 16.971