| Literature DB >> 2156275 |
Abstract
We compared insulin-requiring diabetic outpatients (n = 49) with normal controls (n = 42) for indices of hypothalamic-pituitary-adrenal (HPA) axis activity. Diabetic patients showed significantly elevated 9 a.m. plasma levels of cortisol as well as significantly elevated plasma levels of cortisol and adrenocorticotropic hormone (ACTH) at both 4 p.m. before and 4 p.m. after dexamethasone. Also, there was a significant correlation between postdexamethasone plasma levels of ACTH and duration of diabetes. These results suggest that HPA-axis dysregulation is found among diabetic outpatients. The possible psychiatric implications are discussed.Entities:
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Year: 1990 PMID： 2156275 DOI： 10.1016/0165-1781(90)90106-f
Source DB: PubMed Journal: Psychiatry Res ISSN： 0165-1781 Impact factor: 3.222