Shigeo Miyata1, Shoko Hirano, Junzo Kamei. 1. Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo, 142-8501, Japan.
Abstract
RATIONALE: Clinical studies suggest that the prevalence of psychiatric disorders is higher in diabetic patients than in the general population. It has been reported that central serotonin(2A) (5-HT(2A)) receptors may be involved in the pathogenesis and treatment of psychiatric disorders. OBJECTIVES: We examined the effect of streptozotocin-induced diabetes on the function of central 5-HT(2A) receptors in mice. METHODS: Male ICR mice were rendered diabetic by an injection of streptozotocin (200 mg/kg, i.v.). The experiments were conducted 2 weeks after the injection of streptozotocin. To evaluate the central 5-HT(2A) receptor function, head-twitch responses were measured for 15 min immediately after the treatment with (+/-)-2,5-dimethoxy-4-iodoamphetamine (DOI) (0.1-1 mg/kg, s.c.), a selective 5-HT(2) receptor agonist. RESULTS: Significantly fewer head-twitch responses were induced by DOI in diabetic mice than in non-diabetic mice. The number and affinity of 5-HT(2A) receptors in the mouse frontal cortex were not affected by diabetes. The corticosterone response to DOI (1 mg/kg and 3 mg/kg, s.c.) was not different between non-diabetic and diabetic mice, although the baseline of plasma corticosterone levels was significantly higher in diabetic than in non-diabetic mice. CONCLUSIONS: Our results suggest that a neuronal network that causes head-twitch responses by triggering by the activation of 5-HT(2A) receptors may be altered by type-1 diabetes in mice.
RATIONALE: Clinical studies suggest that the prevalence of psychiatric disorders is higher in diabeticpatients than in the general population. It has been reported that central serotonin(2A) (5-HT(2A)) receptors may be involved in the pathogenesis and treatment of psychiatric disorders. OBJECTIVES: We examined the effect of streptozotocin-induced diabetes on the function of central 5-HT(2A) receptors in mice. METHODS: Male ICR mice were rendered diabetic by an injection of streptozotocin (200 mg/kg, i.v.). The experiments were conducted 2 weeks after the injection of streptozotocin. To evaluate the central 5-HT(2A) receptor function, head-twitch responses were measured for 15 min immediately after the treatment with (+/-)-2,5-dimethoxy-4-iodoamphetamine (DOI) (0.1-1 mg/kg, s.c.), a selective 5-HT(2) receptor agonist. RESULTS: Significantly fewer head-twitch responses were induced by DOI in diabeticmice than in non-diabeticmice. The number and affinity of 5-HT(2A) receptors in the mouse frontal cortex were not affected by diabetes. The corticosterone response to DOI (1 mg/kg and 3 mg/kg, s.c.) was not different between non-diabetic and diabeticmice, although the baseline of plasma corticosterone levels was significantly higher in diabetic than in non-diabeticmice. CONCLUSIONS: Our results suggest that a neuronal network that causes head-twitch responses by triggering by the activation of 5-HT(2A) receptors may be altered by type-1 diabetes in mice.
Authors: D Attar-Lévy; J L Martinot; J Blin; M H Dao-Castellana; C Crouzel; B Mazoyer; M F Poirier; M C Bourdel; N Aymard; A Syrota; A Féline Journal: Biol Psychiatry Date: 1999-01-15 Impact factor: 13.382
Authors: Jeremy M Veenstra-Vanderweele; Aurelio Galli; Christine Saunders; Michael Siuta; Sabrina D Robertson; Adeola R Davis; Jennifer Sauer; Heinrich J G Matthies; Paul J Gresch; David Airey; Craig W Lindsley; John A Schetz; Kevin D Niswender Journal: Neurochem Int Date: 2013-09-30 Impact factor: 3.921