Literature DB >> 2156231

SLACS retrotransposon from Trypanosoma brucei gambiense is similar to mammalian LINEs.

S Aksoy1, S Williams, S Chang, F F Richards.   

Abstract

We have characterized a retrotransposon in Trypanosoma brucei gambiense uniquely associated with the spliced-leader (SL) RNA gene cluster (Spliced Leader Associated Conserved Sequence, SLACS). There are nine copies of SLACS and DNA sequence analysis of one shows the hallmarks of Line-1 like elements. SLACS has generated a 49 bp target DNA duplication at its insertion site and its 3'-end is preceded by a poly(A) stretch. Two putative open reading frames (ORFs) span 75% of the element. ORF1 has CysHis motif associated with the retroviral gag polypeptide while ORF2 shows homology with reverse transcriptase sequences. Its 5'-end contains a repeated segment of a 185 bp that varies in copy number in different SLACS insertions. Retrotransposon-like sequences inserted into the SL-RNA genes occur in several hemoflagellates. These elements may represent a related family which has maintained its target site specificity.

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Year:  1990        PMID： 2156231      PMCID： PMC330328          DOI： 10.1093/nar/18.4.785

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  29 in total

1.  Ingi, a 5.2-kb dispersed sequence element from Trypanosoma brucei that carries half of a smaller mobile element at either end and has homology with mammalian LINEs.

Authors:  B E Kimmel; O K ole-MoiYoi; J R Young
Journal:  Mol Cell Biol       Date:  1987-04       Impact factor: 4.272

2.  jockey, a mobile Drosophila element similar to mammalian LINEs, is transcribed from the internal promoter by RNA polymerase II.

Authors:  L J Mizrokhi; S G Georgieva; Y V Ilyin
Journal:  Cell       Date:  1988-08-26       Impact factor: 41.582

3.  The structure and transcription of an element interspersed between tandem arrays of mini-exon donor RNA genes in Trypanosoma brucei.

Authors:  M Carrington; I Roditi; R O Williams
Journal:  Nucleic Acids Res       Date:  1987-12-23       Impact factor: 16.971

4.  The site-specific ribosomal DNA insertion element R1Bm belongs to a class of non-long-terminal-repeat retrotransposons.

Authors:  Y Xiong; T H Eickbush
Journal:  Mol Cell Biol       Date:  1988-01       Impact factor: 4.272

5.  DNA-binding fingers encoded by a trypanosome retroposon.

Authors:  E Pays; N B Murphy
Journal:  J Mol Biol       Date:  1987-09-05       Impact factor: 5.469

6.  Trypanosoma brucei repeated element with unusual structural and transcriptional properties.

Authors:  N B Murphy; A Pays; P Tebabi; H Coquelet; M Guyaux; M Steinert; E Pays
Journal:  J Mol Biol       Date:  1987-06-20       Impact factor: 5.469

7.  Discontinuous transcription in Leptomonas seymouri: presence of intact and interrupted mini-exon gene families.

Authors:  V Bellofatto; R Cooper; G A Cross
Journal:  Nucleic Acids Res       Date:  1988-08-11       Impact factor: 16.971

8.  The site-specific ribosomal insertion element type II of Bombyx mori (R2Bm) contains the coding sequence for a reverse transcriptase-like enzyme.

Authors:  W D Burke; C C Calalang; T H Eickbush
Journal:  Mol Cell Biol       Date:  1987-06       Impact factor: 4.272

9.  Multiple copies of a retroposon interrupt spliced leader RNA genes in the African trypanosome, Trypanosoma gambiense.

Authors:  S Aksoy; T M Lalor; J Martin; L H Van der Ploeg; F F Richards
Journal:  EMBO J       Date:  1987-12-01       Impact factor: 11.598

10.  Origin of the human L1 elements: proposed progenitor genes deduced from a consensus DNA sequence.

Authors:  A F Scott; B J Schmeckpeper; M Abdelrazik; C T Comey; B O'Hara; J P Rossiter; T Cooley; P Heath; K D Smith; L Margolet
Journal:  Genomics       Date:  1987-10       Impact factor: 5.736
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  40 in total

1.  Identification of the endonuclease domain encoded by R2 and other site-specific, non-long terminal repeat retrotransposable elements.

Authors:  J Yang; H S Malik; T H Eickbush
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-06       Impact factor: 11.205

2.  RNA interference in Trypanosoma brucei: cloning of small interfering RNAs provides evidence for retroposon-derived 24-26-nucleotide RNAs.

Authors:  A Djikeng; H Shi; C Tschudi; E Ullu
Journal:  RNA       Date:  2001-11       Impact factor: 4.942

3.  Three retrotransposon families in the genome of Giardia lamblia: two telomeric, one dead.

Authors:  I R Arkhipova; H G Morrison
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-04       Impact factor: 11.205

Review 4.  Mobile genetic elements in protozoan parasites.

Authors:  Sudha Bhattacharya; Abhijeet Bakre; Alok Bhattacharya
Journal:  J Genet       Date:  2002-08       Impact factor: 1.166

Review 5.  Repetitive elements in genomes of parasitic protozoa.

Authors:  Bill Wickstead; Klaus Ersfeld; Keith Gull
Journal:  Microbiol Mol Biol Rev       Date:  2003-09       Impact factor: 11.056

6.  Identification of an internal cis-element essential for the human L1 transcription and a nuclear factor(s) binding to the element.

Authors:  R Minakami; K Kurose; K Etoh; Y Furuhata; M Hattori; Y Sakaki
Journal:  Nucleic Acids Res       Date:  1992-06-25       Impact factor: 16.971

7.  Identification of transcriptional regulatory activity within the 5' A-type monomer sequence of the mouse LINE-1 retroposon.

Authors:  D M Severynse; C A Hutchison; M H Edgell
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

8.  A LINE-like transposable element in Drosophila, the I factor, encodes a protein with properties similar to those of retroviral nucleocapsids.

Authors:  A Dawson; E Hartswood; T Paterson; D J Finnegan
Journal:  EMBO J       Date:  1997-07-16       Impact factor: 11.598

9.  A new member of a family of site-specific retrotransposons is present in the spliced leader RNA genes of Trypanosoma cruzi.

Authors:  M S Villanueva; S P Williams; C B Beard; F F Richards; S Aksoy
Journal:  Mol Cell Biol       Date:  1991-12       Impact factor: 4.272

10.  Non-LTR retrotransposons in fungi.

Authors:  Olga Novikova; Victor Fet; Alexander Blinov
Journal:  Funct Integr Genomics       Date:  2008-08-02       Impact factor: 3.410
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