Radial glia: progenitor, pathway, and partner.

Radial glia (RG) are a glial cell type that can be found from the earliest stages of CNS development. They are clearly identifiable by their unique morphology, having a periventricular cell soma and a long process extending all the way to the opposite pial surface. Due to this striking morphology, RG have long been thought of as a transient substrate for neuron migration in the developing brain. In fact, RG cells, far from exclusively serving as a passive scaffold for cell migration, have a remarkably diverse range of critical functions in CNS development and function. These include serving as progenitors of neurons and glia both during development as well as in response to injury, helping to direct axonal and dendritic process outgrowth, and regulating synaptic development and function. RG also engage in extensive bidirectional signaling both with neurons and one another. This review describes the diversity of RG cell types in the CNS and discusses their many important activities.