Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Light chain gene conversion continues at high rate in an ALV-induced cell line.

Literature DB >> 2155784

Light chain gene conversion continues at high rate in an ALV-induced cell line.

J M Buerstedde¹, C A Reynaud, E H Humphries, W Olson, D L Ewert, J C Weill.

Abstract

We have analyzed immunoglobulin light chain sequences from avian leukosis virus (ALV) induced bursal and metastatic tumors and from cell lines derived from these tumors. Sequence data presented demonstrate that ALV-induced tumors and one cell line (DT40) derived therefrom continue to diversify their light chain genes outside of the bursal environment. Diversification within these tumor cells seems to occur by gene conversion events comparable with those observed in bursal B cells. Sequence analysis of spontaneously arising surface immunoglobulin negative subclones of the DT40 cell line revealed frameshifts within the rearranged light chain genes which most likely resulted from non-functional recombination events. Superimposed gene conversion events can repair these frameshifts leading to re-expression of surface immunoglobulin.

Entities: Chemical

Mesh：

Substances：

Year: 1990 PMID： 2155784 PMCID： PMC551754 DOI： 10.1002/j.1460-2075.1990.tb08190.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

14 in total

1. A hyperconversion mechanism generates the chicken light chain preimmune repertoire.

Authors: C A Reynaud; V Anquez; H Grimal; J C Weill
Journal: Cell Date: 1987-02-13 Impact factor: 41.582

2. Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment.

Authors: C B Thompson; P E Neiman
Journal: Cell Date: 1987-02-13 Impact factor: 41.582

3. Cell lines derived from avian lymphomas exhibit two distinct phenotypes.

Authors: T W Baba; B P Giroir; E H Humphries
Journal: Virology Date: 1985-07-15 Impact factor: 3.616

4. A single rearrangement event generates most of the chicken immunoglobulin light chain diversity.

Authors: C A Reynaud; V Anquez; A Dahan; J C Weill
Journal: Cell Date: 1985-02 Impact factor: 41.582

5. Selection for B cells with productive IgL gene rearrangements occurs in the bursa of Fabricius during chicken embryonic development.

Authors: W T McCormack; L W Tjoelker; C F Barth; L M Carlson; B Petryniak; E H Humphries; C B Thompson
Journal: Genes Dev Date: 1989-06 Impact factor: 11.361

6. Rearrangement of chicken immunoglobulin genes is not an ongoing process in the embryonic bursa of Fabricius.

Authors: J C Weill; C A Reynaud; O Lassila; J R Pink
Journal: Proc Natl Acad Sci U S A Date: 1986-05 Impact factor: 11.205

7. Endogenous viral genes are non-essential in the chicken.

Authors: S M Astrin; E G Buss; W S Haywards
Journal: Nature Date: 1979-11-15 Impact factor: 49.962

8. Avian leukosis virus-induced tumors have common proviral integration sites and synthesize discrete new RNAs: oncogenesis by promoter insertion.

Authors: B G Neel; W S Hayward; H L Robinson; J Fang; S M Astrin
Journal: Cell Date: 1981-02 Impact factor: 41.582

9. The effect of alterations in myc gene expression on B cell development in the bursa of Fabricius.

Authors: C B Thompson; E H Humphries; L M Carlson; C L Chen; P E Neiman
Journal: Cell Date: 1987-11-06 Impact factor: 41.582

10. Evidence for an IgD homologue on chicken lymphocytes.

Authors: C L Chen; J E Lehmeyer; M D Cooper
Journal: J Immunol Date: 1982-12 Impact factor: 5.422

79 in total

1. Development of B cells expressing surface immunoglobulin molecules that lack V(D)J-encoded determinants in the avian embryo bursa of fabricius.

Authors: C E Sayegh; S L Demaries; S Iacampo; M J Ratcliffe
Journal: Proc Natl Acad Sci U S A Date: 1999-09-14 Impact factor: 11.205

Review 2. Reverse genetic studies of homologous DNA recombination using the chicken B-lymphocyte line, DT40.

Authors: E Sonoda; C Morrison; Y M Yamashita; M Takata; S Takeda
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2001-01-29 Impact factor: 6.237

Review 3. Homologous DNA recombination in vertebrate cells.

Authors: E Sonoda; M Takata; Y M Yamashita; C Morrison; S Takeda
Journal: Proc Natl Acad Sci U S A Date: 2001-07-17 Impact factor: 11.205

4. The Rad51 paralog Rad51B promotes homologous recombinational repair.

Authors: M Takata; M S Sasaki; E Sonoda; T Fukushima; C Morrison; J S Albala; S M Swagemakers; R Kanaar; L H Thompson; S Takeda
Journal: Mol Cell Biol Date: 2000-09 Impact factor: 4.272

5. Karyotype stability of the DT40 chicken B cell line: macrochromosome variation and cytogenetic mosaicism.

Authors: Hong Chang; Mary E Delany
Journal: Chromosome Res Date: 2004 Impact factor: 5.239

6. DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.

Authors: Laurent Maloisel; Francis Fabre; Serge Gangloff
Journal: Mol Cell Biol Date: 2007-12-17 Impact factor: 4.272

7. RAG-2 expression is not essential for chicken immunoglobulin gene conversion.

Authors: S Takeda; E L Masteller; C B Thompson; J M Buerstedde
Journal: Proc Natl Acad Sci U S A Date: 1992-05-01 Impact factor: 11.205

8. Analysis of the chicken TBP-like protein(tlp) gene: evidence for a striking conservation of vertebrate TLPs and for a close relationship between vertebrate tbp and tlp genes.

Authors: M Shimada; T Ohbayashi; M Ishida; T Nakadai; Y Makino; T Aoki; T Kawata; T Suzuki; Y Matsuda; T Tamura
Journal: Nucleic Acids Res Date: 1999-08-01 Impact factor: 16.971

9. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells.

Authors: M Takata; M S Sasaki; E Sonoda; C Morrison; M Hashimoto; H Utsumi; Y Yamaguchi-Iwai; A Shinohara; S Takeda
Journal: EMBO J Date: 1998-09-15 Impact factor: 11.598

10. Identification of a chicken RAD52 homologue suggests conservation of the RAD52 recombination pathway throughout the evolution of higher eukaryotes.

Authors: O Y Bezzubova; H Schmidt; K Ostermann; W D Heyer; J M Buerstedde
Journal: Nucleic Acids Res Date: 1993-12-25 Impact factor: 16.971