Literature DB >> 3010290

Rearrangement of chicken immunoglobulin genes is not an ongoing process in the embryonic bursa of Fabricius.

J C Weill, C A Reynaud, O Lassila, J R Pink.   

Abstract

We report a molecular analysis of the chicken Ig loci in single bursal follicles from 3- to 7-week-old chickens. Each follicle contained between 10(5) and 3 X 10(5) cells. The Ig gene rearrangement patterns obtained were compared to the pattern observed with the corresponding total bursal DNA. The results obtained for the light chain locus imply that a very small number (two on average) of rearrangement events takes place in each follicle. For the heavy chain locus similar results were obtained, each follicle showing a more restricted pattern than the total bursa. These data favor a model in which each follicle is colonized by a very few prebursal stem cells that are committed to a particular Ig gene rearrangement at the very beginning of the development of the embryonic bursa. The role of the bursa as the organ in which such a committed stem cell population for the B-cell lineage arises is discussed.

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Year:  1986        PMID： 3010290      PMCID： PMC323508          DOI： 10.1073/pnas.83.10.3336

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  31 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

2.  Long-term cultured B lymphocytes and their precursors reconstitute the B-lymphocyte lineage in vivo.

Authors:  J I Kurland; S F Ziegler; O N Witte
Journal:  Proc Natl Acad Sci U S A       Date:  1984-12       Impact factor: 11.205

3.  Complete sequence of a chicken lambda light chain immunoglobulin derived from the nucleotide sequence of its mRNA.

Authors:  C A Reynaud; A Dahan; J C Weill
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205

4.  Nucleotide sequence of the constant region of a chicken mu heavy chain immunoglobulin mRNA.

Authors:  A Dahan; C A Reynaud; J C Weill
Journal:  Nucleic Acids Res       Date:  1983-08-25       Impact factor: 16.971

5.  A single rearrangement event generates most of the chicken immunoglobulin light chain diversity.

Authors:  C A Reynaud; V Anquez; A Dahan; J C Weill
Journal:  Cell       Date:  1985-02       Impact factor: 41.582

6.  Nomenclature for chicken major histocompatibility (B) complex.

Authors:  W E Briles; N Bumstead; D L Ewert; D G Gilmour; J Gogusev; K Hála; C Koch; B M Longenecker; A W Nordskog; J R Pink; L W Schierman; M Simonsen; A Toivanen; P Toivanen; O Vainio; G Wick
Journal:  Immunogenetics       Date:  1982       Impact factor: 2.846

7.  Cmu gene rearrangement of mouse immunoglobulin genes in normal B cells occurs on both the expressed and nonexpressed chromosomes.

Authors:  C Nottenburg; I L Weissman
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205

8.  Allotype suppression in the chicken. IV. Deletion of B cells and lack of suppressor cells during chronic suppression.

Authors:  M J Ratcliffe; J Ivanyi
Journal:  Eur J Immunol       Date:  1981-04       Impact factor: 5.532

9.  Ordered rearrangement of immunoglobulin heavy chain variable region segments.

Authors:  F W Alt; G D Yancopoulos; T K Blackwell; C Wood; E Thomas; M Boss; R Coffman; N Rosenberg; S Tonegawa; D Baltimore
Journal:  EMBO J       Date:  1984-06       Impact factor: 11.598

10.  Development of adult bone marrow stem cells in H-2-compatible and -incompatible mouse fetuses.

Authors:  R A Fleischman; B Mintz
Journal:  J Exp Med       Date:  1984-03-01       Impact factor: 14.307
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  18 in total

1.  Stochastic rearrangement of immunoglobulin variable-region genes in chicken B-cell development.

Authors:  T Benatar; L Tkalec; M J Ratcliffe
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

2.  Somatic diversification of chicken immunoglobulin light chains by point mutations.

Authors:  R Parvari; E Ziv; F Lantner; D Heller; I Schechter
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

3.  RAG-2 expression is not essential for chicken immunoglobulin gene conversion.

Authors:  S Takeda; E L Masteller; C B Thompson; J M Buerstedde
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

Review 4.  Somatic diversification of antibody responses.

Authors:  B Zheng; G Kelsoe; S Han
Journal:  J Clin Immunol       Date:  1996-01       Impact factor: 8.317

5.  Rearrangement and diversification of immunoglobulin light-chain genes in lymphoid cells transformed by reticuloendotheliosis virus.

Authors:  J Y Zhang; W Bargmann; H R Bose
Journal:  Mol Cell Biol       Date:  1989-11       Impact factor: 4.272

6.  Rearrangements of chicken immunoglobulin genes in lymphoid cells transformed by the avian retroviral oncogene v-rel.

Authors:  L Chen; M Y Lim; H Bose; J M Bishop
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

7.  Ongoing diversification of the rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line.

Authors:  S Kim; E H Humphries; L Tjoelker; L Carlson; C B Thompson
Journal:  Mol Cell Biol       Date:  1990-06       Impact factor: 4.272

Review 8.  Gene conversion in the chicken immunoglobulin locus: a paradigm of homologous recombination in higher eukaryotes.

Authors:  O Y Bezzubova; J M Buerstedde
Journal:  Experientia       Date:  1994-03-15

9.  T-cell specific avian TdT: characterization of the cDNA and recombinant enzyme.

Authors:  B Yang; K N Gathy; M S Coleman
Journal:  Nucleic Acids Res       Date:  1995-06-11       Impact factor: 16.971

10.  Differential selection of cells with proviral c-myc and c-erbB integrations after avian leukosis virus infection.

Authors:  M Gong; H L Semus; K J Bird; B J Stramer; A Ruddell
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103
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