We report a Ni-catalyzed process for the cross-coupling of tertiary alkyl nucleophiles and aryl bromides. This process is extremely general for a wide range of electrophiles and generally occurs with a ratio of retention to isomerization >30:1. The same procedure also accommodates the use of aryl triflates, vinyl chlorides, and vinyl bromides as the electrophilic component.
We report a Ni-catalyzed process for the cross-coupling of tertiary alkyl nucleophiles and n class="Chemical">aryl bromides. This process is extremely general for a wide range of electrophiles and generally occurs with a ratio of retention to isomerization >30:1. The same procedure also accommodates the use of aryl triflates, vinyl chlorides, and vinyl bromides as the electrophilic component.
Authors: Tie-Gen Chen; Haolin Zhang; Pavel K Mykhailiuk; Rohan R Merchant; Courtney A Smith; Tian Qin; Phil S Baran Journal: Angew Chem Int Ed Engl Date: 2019-01-30 Impact factor: 15.336
Authors: Stephen R Sardini; Alison L Lambright; Grace L Trammel; Humair M Omer; Peng Liu; M Kevin Brown Journal: J Am Chem Soc Date: 2019-06-04 Impact factor: 15.419
Authors: Allison M Bergmann; Stanna K Dorn; Kevin B Smith; Kaitlyn M Logan; M Kevin Brown Journal: Angew Chem Int Ed Engl Date: 2019-01-09 Impact factor: 15.336