| Literature DB >> 18047363 |
Laurin Melzig1, Andrey Gavryushin, Paul Knochel.
Abstract
A direct room-temperature Ni-catalyzed cross-coupling of aminoalkylzinc halides, readily available from the corresponding aminoalkyl chlorides via Grignard reagents, with aryl and hetaryl electrophiles, allows a convenient one-step preparation of aminoalkyl (het)arenes, bearing a basic tertiary nitrogen in the side chain, including piperidine and tropane derivatives. Such aminoalkylarene scaffolds are widely present in various biologically active molecules.Entities:
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Year: 2007 PMID： 18047363 DOI： 10.1021/ol702499h
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005