Literature DB >> 21553814

Synthesis of benzocycloheptanones through coupling of δ,ε-unsaturated chromium carbene complexes and 2-alkynylbenzoyl derivatives.

Rajesh Kumar Patti1, Kristopher V Waynant, James W Herndon.   

Abstract

The coupling of pentenylcarbene complexes and 2-alkynylbenzoyl derivatives affords naphthocycloheptanones in a single step involving simultaneous construction of both the seven-membered ring and one of the aromatic rings. Aryl tethered systems undergo intramolecular cyclopropanation.

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Year:  2011        PMID： 21553814      PMCID： PMC3109730          DOI： 10.1021/ol200825j

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  12 in total

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2.  A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity.

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5.  Generation and trapping of isobenzofuran intermediates formed in the coupling of Fischer carbene complexes and o-alkynylbenzoyl derivatives

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Journal:  Org Lett       Date:  2000-05-04       Impact factor: 6.005

6.  Novel potent antagonists of human neuropeptide Y Y5 receptors. Part 3: 7-methoxy-1-hydroxy-1-substituted tetraline derivatives.

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7.  Synthesis of alkylidenephthalans through fluoride-induced cyclization of electron-deficient 2-siloxymethylphenylacetylene derivatives.

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9.  Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy.

Authors:  Madhavi Sriram; John J Hall; Nathan C Grohmann; Tracy E Strecker; Taylor Wootton; Andreas Franken; Mary Lynn Trawick; Kevin G Pinney
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10.  (R)- and (S)-5,6,7,8-tetrahydro-1-hydroxy-N,N-dipropyl-9H-benzocyclohepten- 8-ylamine. Stereoselective interactions with 5-HT1A receptors in the brain.

Authors:  Y Liu; C Mellin; L Björk; B Svensson; I Csöregh; A Helander; L Kenne; N E Andén; U Hacksell
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  3 in total

1.  The [5+5] route to the phenanthrene skeleton.

Authors:  James W Herndon; Bishnu Dhakal
Journal:  ARKIVOC       Date:  2016-06-21       Impact factor: 1.140

2.  An Amino-Benzosuberene Analogue That Inhibits Tubulin Assembly and Demonstrates Remarkable Cytotoxicity.

Authors:  Rajendra P Tanpure; Clinton S George; Madhavi Sriram; Tracy E Strecker; Justin K Tidmore; Ernest Hamel; Amanda K Charlton-Sevcik; David J Chaplin; Mary Lynn Trawick; Kevin G Pinney
Journal:  Medchemcomm       Date:  2012-06       Impact factor: 3.597

3.  Synthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents.

Authors:  Rajendra P Tanpure; Clinton S George; Tracy E Strecker; Laxman Devkota; Justin K Tidmore; Chen-Ming Lin; Christine A Herdman; Matthew T Macdonough; Madhavi Sriram; David J Chaplin; Mary Lynn Trawick; Kevin G Pinney
Journal:  Bioorg Med Chem       Date:  2013-09-04       Impact factor: 3.641
  3 in total

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