| Literature DB >> 11909705 |
Yoshinari Satoh1, Chie Hatori, Harunobu Ito.
Abstract
Novel tetrahydrodiazabenzazulene derivatives, designed from the lead compound 1 discovered by screening of our in-house chemical library, were prepared and found to be potent neuropeptide Y-Y5 (NPY-Y5) receptor antagonists. The structure-activity relationships are described. Compounds 7 (FR240662) and 16 (FR252384) were especially attractive owing to their high affinities for the NPY-Y5 receptors, oral absorption and permeability to brain.Entities:
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Year: 2002 PMID： 11909705 DOI： 10.1016/s0960-894x(02)00090-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823