BACKGROUND: In order to provide a precise quantification of the association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, we conducted a meta-analysis of available data. PATIENTS AND METHODS: We identified 20 case-control and 4 cohort studies, including a total of 5500 cases. We derived meta-analytic estimates using random-effects models, taking into account correlation between estimates, and we carried out a dose-risk analysis using nonlinear random-effects meta-regression models. RESULTS: The relative risk (RR) for drinkers versus nondrinkers was 0.96 [95% confidence interval (CI) 0.85-1.09] overall, 0.87 (95% CI 0.74-1.01) for esophageal adenocarcinoma and 0.89 (95% CI 0.76-1.03) for gastric cardia adenocarcinoma. Compared with nondrinkers, the pooled RRs were 0.86 for light (≤ 1 drink per day), 0.90 for moderate (1 to < 4 drinks per day), and 1.16 for heavy (≥ 4 drinks per day) alcohol drinking. The dose-risk model found a minimum at 25 g/day, and the curve was < 1 up to 70 g/day. CONCLUSIONS: This meta-analysis provides definite evidence of an absence of association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, even at higher doses of consumption.
BACKGROUND: In order to provide a precise quantification of the association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, we conducted a meta-analysis of available data. PATIENTS AND METHODS: We identified 20 case-control and 4 cohort studies, including a total of 5500 cases. We derived meta-analytic estimates using random-effects models, taking into account correlation between estimates, and we carried out a dose-risk analysis using nonlinear random-effects meta-regression models. RESULTS: The relative risk (RR) for drinkers versus nondrinkers was 0.96 [95% confidence interval (CI) 0.85-1.09] overall, 0.87 (95% CI 0.74-1.01) for esophageal adenocarcinoma and 0.89 (95% CI 0.76-1.03) for gastric cardia adenocarcinoma. Compared with nondrinkers, the pooled RRs were 0.86 for light (≤ 1 drink per day), 0.90 for moderate (1 to < 4 drinks per day), and 1.16 for heavy (≥ 4 drinks per day) alcohol drinking. The dose-risk model found a minimum at 25 g/day, and the curve was < 1 up to 70 g/day. CONCLUSIONS: This meta-analysis provides definite evidence of an absence of association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, even at higher doses of consumption.
Authors: S Kroep; I Lansdorp-Vogelaar; J H Rubenstein; V E P P Lemmens; E B van Heijningen; N Aragonés; M van Ballegooijen; J M Inadomi Journal: Am J Gastroenterol Date: 2013-12-17 Impact factor: 10.864
Authors: Harindra Jayasekara; Robert J MacInnis; Leila Lujan-Barroso; Ana-Lucia Mayen-Chacon; Amanda J Cross; Bengt Wallner; Domenico Palli; Fulvio Ricceri; Valeria Pala; Salvatore Panico; Rosario Tumino; Tilman Kühn; Rudolf Kaaks; Kostas Tsilidis; Maria-Jose Sánchez; Pilar Amiano; Eva Ardanaz; María Dolores Chirlaque López; Susana Merino; Joseph A Rothwell; Marie-Christine Boutron-Ruault; Gianluca Severi; Hanna Sternby; Emily Sonestedt; Bas Bueno-de-Mesquita; Heiner Boeing; Ruth Travis; Torkjel M Sandanger; Antonia Trichopoulou; Anna Karakatsani; Eleni Peppa; Anne Tjønneland; Yi Yang; Allison M Hodge; Hazel Mitchell; Andrew Haydon; Robin Room; John L Hopper; Elisabete Weiderpass; Marc J Gunter; Elio Riboli; Graham G Giles; Roger L Milne; Antonio Agudo; Dallas R English; Pietro Ferrari Journal: Int J Cancer Date: 2021-02-22 Impact factor: 7.316