Literature DB >> 2154893

Mouse hepatitis virus ORF 2a is expressed in the cytosol of infected mouse fibroblasts.

P W Zoltick1, J L Leibowitz, E L Oleszak, S R Weiss.   

Abstract

A 266-bp fragment of cDNA from within gene B, ORF 2a, of MHV-A59 was used to construct a vector encoding a bacterial/viral fusion protein. Antiserum raised against this fusion protein specifically immunoprecipitates a 30K protein from infected 17Cl-1 mouse fibroblasts. The protein is localized primarily in the cytosol and not in the membranes. This is consistent with its predicted sequence and potential role as an RNA binding protein.

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Year:  1990        PMID： 2154893      PMCID： PMC7131050          DOI： 10.1016/0042-6822(90)90114-7

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  12 in total

Review 1.  Coronaviruses: structure and genome expression.

Authors:  W Spaan; D Cavanagh; M C Horzinek
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2.  Coding sequence of coronavirus MHV-JHM mRNA 4.

Authors:  M A Skinner; S G Siddell
Journal:  J Gen Virol       Date:  1985-03       Impact factor: 3.891

3.  Cell-free translation of murine coronavirus RNA.

Authors:  J L Leibowitz; S R Weiss; E Paavola; C W Bond
Journal:  J Virol       Date:  1982-09       Impact factor: 5.103

4.  Characterization of two RNA polymerase activities induced by mouse hepatitis virus.

Authors:  P R Brayton; M M Lai; C D Patton; S A Stohlman
Journal:  J Virol       Date:  1982-06       Impact factor: 5.103

5.  Genetic analysis of murine hepatitis virus strain JHM.

Authors:  J L Leibowitz; J R DeVries; M V Haspel
Journal:  J Virol       Date:  1982-06       Impact factor: 5.103

6.  In vitro synthesis of two polypeptides from a nonstructural gene of coronavirus mouse hepatitis virus strain A59.

Authors:  C J Budzilowicz; S R Weiss
Journal:  Virology       Date:  1987-04       Impact factor: 3.616

7.  Coronavirus MHV-JHM mRNA 5 has a sequence arrangement which potentially allows translation of a second, downstream open reading frame.

Authors:  M A Skinner; D Ebner; S G Siddell
Journal:  J Gen Virol       Date:  1985-03       Impact factor: 3.891

8.  Molecular cloning of the gene encoding the putative polymerase of mouse hepatitis coronavirus, strain A59.

Authors:  C J Pachuk; P J Bredenbeek; P W Zoltick; W J Spaan; S R Weiss
Journal:  Virology       Date:  1989-07       Impact factor: 3.616

9.  Sequence of mouse hepatitis virus A59 mRNA 2: indications for RNA recombination between coronaviruses and influenza C virus.

Authors:  W Luytjes; P J Bredenbeek; A F Noten; M C Horzinek; W J Spaan
Journal:  Virology       Date:  1988-10       Impact factor: 3.616

10.  The virus-specific intracellular RNA species of two murine coronaviruses: MHV-a59 and MHV-JHM.

Authors:  J L Leibowitz; K C Wilhelmsen; C W Bond
Journal:  Virology       Date:  1981-10-15       Impact factor: 3.616
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  14 in total

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Authors:  A Lissenberg; M M Vrolijk; A L W van Vliet; M A Langereis; J D F de Groot-Mijnes; P J M Rottier; R J de Groot
Journal:  J Virol       Date:  2005-12       Impact factor: 5.103

Review 2.  Viral phosphodiesterases that antagonize double-stranded RNA signaling to RNase L by degrading 2-5A.

Authors:  Robert H Silverman; Susan R Weiss
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3.  Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice.

Authors:  Steven M Sperry; Lubna Kazi; Rachel L Graham; Ralph S Baric; Susan R Weiss; Mark R Denison
Journal:  J Virol       Date:  2005-03       Impact factor: 5.103

4.  Murine coronavirus nonstructural protein ns2 is not essential for virus replication in transformed cells.

Authors:  B Schwarz; E Routledge; S G Siddell
Journal:  J Virol       Date:  1990-10       Impact factor: 5.103

Review 5.  Coronavirus pathogenesis.

Authors:  Susan R Weiss; Julian L Leibowitz
Journal:  Adv Virus Res       Date:  2011       Impact factor: 9.937

6.  Organ-specific attenuation of murine hepatitis virus strain A59 by replacement of catalytic residues in the putative viral cyclic phosphodiesterase ns2.

Authors:  Jessica K Roth-Cross; Helen Stokes; Guohui Chang; Ming Ming Chua; Volker Thiel; Susan R Weiss; Alexander E Gorbalenya; Stuart G Siddell
Journal:  J Virol       Date:  2009-01-28       Impact factor: 5.103

7.  Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity.

Authors:  Rong Zhang; Babal K Jha; Kristen M Ogden; Beihua Dong; Ling Zhao; Ruth Elliott; John T Patton; Robert H Silverman; Susan R Weiss
Journal:  Proc Natl Acad Sci U S A       Date:  2013-07-22       Impact factor: 11.205

8.  Two murine coronavirus genes suffice for viral RNA synthesis.

Authors:  K H Kim; S Makino
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9.  Crystal structure of the C-terminal 2',5'-phosphodiesterase domain of group A rotavirus protein VP3.

Authors:  Tobias Brandmann; Martin Jinek
Journal:  Proteins       Date:  2015-03-25

10.  The ns 4 gene of mouse hepatitis virus (MHV), strain A 59 contains two ORFs and thus differs from ns 4 of the JHM and S strains.

Authors:  S R Weiss; P W Zoltick; J L Leibowitz
Journal:  Arch Virol       Date:  1993       Impact factor: 2.574
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