| Literature DB >> 21548658 |
Bruce H Lipshutz1, Subir Ghorai, Alexander R Abela, Ralph Moser, Takashi Nishikata, Christophe Duplais, Arkady Krasovskiy, Ricky D Gaston, Robert C Gadwood.
Abstract
An environmentally benign surfactant (TPGS-750-M), a diester composed of racemic α-tocopherol, MPEG-750, and succinic acid, has been designed and readily prepared as an effective nanomicelle-forming species for general use in metal-catalyzed cross-coupling reactions in water. Several "name" reactions, including Heck, Suzuki-Miyaura, Sonogashira, and Negishi-like couplings, have been studied using this technology, as have aminations, C-H activations, and olefin metathesis reactions. Physical data in the form of DLS and cryo-TEM measurements suggest that particle size and shape are key elements in achieving high levels of conversion and, hence, good isolated yields of products. This new amphiphile will soon be commercially available.Entities:
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Year: 2011 PMID： 21548658 PMCID： PMC3608414 DOI： 10.1021/jo101974u
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354