A single set of conditions consisting of a palladium catalyst, a commercially available ligand, and a base, allow for several types of C-N bond constructions to be conducted in water with the aid of a commercially available "designer" surfactant (TPGS-750-M). Products containing a protected NH2 group in the form of a carbamate, sulfonamide, or urea can be fashioned starting with aryl or heteroaryl bromides, iodides, and in some cases, chlorides, as substrates. Reaction temperatures are in the range of room temperature to, at most, 50 °C, and result in essentially full conversion and good isolated yields.
A single set of conditions consisting of a palladium catalyst, a commercially available ligand, and a base, allow for several types of C-N bond constructions to be conducted in n class="Chemical">water with the aid of a commercially available "designer" surfactant (TPGS-750-M). Products containing a protected NH2 group in the form of a carbamate, sulfonamide, or urea can be fashioned starting with aryl or heteroaryl bromides, iodides, and in some cases, chlorides, as substrates. Reaction temperatures are in the range of room temperature to, at most, 50 °C, and result in essentially full conversion and good isolated yields.
Authors: Nicolas Marion; Oscar Navarro; Jianguo Mei; Edwin D Stevens; Natalie M Scott; Steven P Nolan Journal: J Am Chem Soc Date: 2006-03-29 Impact factor: 15.419
Authors: Sebastian C Cosgrove; Matthew P Thompson; Syed T Ahmed; Fabio Parmeggiani; Nicholas J Turner Journal: Angew Chem Int Ed Engl Date: 2020-08-11 Impact factor: 15.336
Authors: M Teresa De Martino; Loai K E A Abdelmohsen; Floris P J T Rutjes; Jan C M van Hest Journal: Beilstein J Org Chem Date: 2018-03-29 Impact factor: 2.883