Literature DB >> 21544394

Antibody-dependent cytotoxic activity on human cancer cells expressing UK 114 tumor membrane antigen.

A Bartorelli1, B Bussolati, M Millesimo, P Gugliotta, G Bussolati.   

Abstract

The monoclonal antibody (P-3 mAb) and the rabbit immune sera (RIS) recognizing a 14 kDa perchloric acid soluble protein extracted from goat liver (UK 114), locate this antigen on the cell membrane of several human cancer cell lines. UK 114-positive cells (e.g. HT 29 and KATO VI cells) undergo antibody-dependent cytolysis bl vitro. In nu/nu mice bearing xenografted HT 29 cells, tumor growth was markedly impaired by peri-tumoral injection of anti-UK 114 antibodies. These experiments suggest that human tumors expressing UK 114 over the cell membrane may undergo antibody-mediated cytolysis and growth control.

Entities:  

Year:  1996        PMID： 21544394     DOI： 10.3892/ijo.8.3.543

Source DB:  PubMed          Journal:  Int J Oncol        ISSN： 1019-6439            Impact factor:   5.650


  7 in total

1.  Identification of a perchloric acid-soluble protein (PSP)-like ribonuclease from Trichomonas vaginalis.

Authors:  Alma Villalobos-Osnaya; Georgina Garza-Ramos; Iris N Serratos; César Millán-Pacheco; Arturo González-Robles; Rossana Arroyo; Laura Itzel Quintas-Granados; María Elizbeth Alvarez-Sanchez
Journal:  Parasitol Res       Date:  2018-09-06       Impact factor: 2.289

Review 2.  From microbiology to cancer biology: the Rid protein family prevents cellular damage caused by endogenously generated reactive nitrogen species.

Authors:  Diana M Downs; Dustin C Ernst
Journal:  Mol Microbiol       Date:  2015-02-26       Impact factor: 3.501

3.  Using D- and L-Amino Acid Oxidases to Generate the Imino Acid Substrate to Measure the Activity of the Novel Rid (Enamine/Imine Deaminase) Class of Enzymes.

Authors:  Stefania Digiovanni; Genny Degani; Laura Popolo; Maria Antonietta Vanoni
Journal:  Methods Mol Biol       Date:  2021

4.  CHRD, a plant member of the evolutionarily conserved YjgF family, influences photosynthesis and chromoplastogenesis.

Authors:  Yael Leitner-Dagan; Marianna Ovadis; Amir Zuker; Elena Shklarman; Itzhak Ohad; Tzvi Tzfira; Alexander Vainstein
Journal:  Planta       Date:  2006-07-15       Impact factor: 4.116

5.  2-Aminoacrylate Stress Induces a Context-Dependent Glycine Requirement in ridA Strains of Salmonella enterica.

Authors:  Dustin C Ernst; Diana M Downs
Journal:  J Bacteriol       Date:  2015-11-16       Impact factor: 3.490

6.  Imine Deaminase Activity and Conformational Stability of UK114, the Mammalian Member of the Rid Protein Family Active in Amino Acid Metabolism.

Authors:  Genny Degani; Alberto Barbiroli; Luca Regazzoni; Laura Popolo; Maria Antonietta Vanoni
Journal:  Int J Mol Sci       Date:  2018-03-22       Impact factor: 5.923

7.  Evidence for a Negative Correlation between Human Reactive Enamine-Imine Intermediate Deaminase A (RIDA) Activity and Cell Proliferation Rate: Role of Lysine Succinylation of RIDA.

Authors:  Luisa Siculella; Laura Giannotti; Benedetta Di Chiara Stanca; Matteo Calcagnile; Alessio Rochira; Eleonora Stanca; Pietro Alifano; Fabrizio Damiano
Journal:  Int J Mol Sci       Date:  2021-04-07       Impact factor: 5.923
  7 in total

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