| Literature DB >> 21539393 |
Jessica L Cohen1, Stephanie Schubert, Peter R Wich, Lina Cui, Joel A Cohen, Justin L Mynar, Jean M J Fréchet.
Abstract
We report a new acid-sensitive, biocompatible, and biodegradable microparticulate delivery system, spermine modified acetalated-dextran (Spermine-Ac-DEX), which can be used to efficiently encapsulate siRNA. These particles demonstrated efficient gene knockdown in HeLa-luc cells with minimal toxicity. This knockdown was comparable to that obtained using Lipofectamine, a commercially available transfection reagent generally limited to in vitro use due to its high toxicity.Entities:
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Year: 2011 PMID： 21539393 PMCID： PMC3152952 DOI： 10.1021/bc100542r
Source DB: PubMed Journal: Bioconjug Chem ISSN： 1043-1802 Impact factor: 4.774