Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Sweet DREAMs for Hippo.

Literature DB >> 21536729

Sweet DREAMs for Hippo.

Abstract

The Hippo pathway coordinates organ size and cell proliferation. The retinoblastoma family of proteins regulates progression through the G0/G1 phase of the cell cycle. Disruption of either pathway contributes to cancer formation. Three recent studies in Genes & Development reveal how cellular proliferation is coordinated between these pathways. Here we discuss the implications of these studies and the new questions that they raise.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2011 PMID： 21536729 PMCID： PMC3084021 DOI： 10.1101/gad.2050411

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

25 in total

1. Extra-embryonic function of Rb is essential for embryonic development and viability.

Authors: Lizhao Wu; Alain de Bruin; Harold I Saavedra; Maja Starovic; Anthony Trimboli; Ying Yang; Jana Opavska; Pamela Wilson; John C Thompson; Michael C Ostrowski; Thomas J Rosol; Laura A Woollett; Michael Weinstein; James C Cross; Michael L Robinson; Gustavo Leone
Journal: Nature Date: 2003-02-27 Impact factor: 49.962

2. Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes.

Authors: Michael Korenjak; Barbie Taylor-Harding; Ulrich K Binné; John S Satterlee; Olivier Stevaux; Rein Aasland; Helen White-Cooper; Nick Dyson; Alexander Brehm
Journal: Cell Date: 2004-10-15 Impact factor: 41.582

3. A kinase shRNA screen links LATS2 and the pRB tumor suppressor.

Authors: Katrin Tschöp; Andrew R Conery; Larisa Litovchick; James A Decaprio; Jeffrey Settleman; Ed Harlow; Nicholas Dyson
Journal: Genes Dev Date: 2011-04-15 Impact factor: 11.361

Review 4. The regulation of E2F by pRB-family proteins.

Authors: N Dyson
Journal: Genes Dev Date: 1998-08-01 Impact factor: 11.361

5. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

Authors: R K Hurford; D Cobrinik; M H Lee; N Dyson
Journal: Genes Dev Date: 1997-06-01 Impact factor: 11.361

Review 6. The retinoblastoma tumour suppressor in development and cancer.

Authors: Marie Classon; Ed Harlow
Journal: Nat Rev Cancer Date: 2002-12 Impact factor: 60.716

7. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.

Authors: Larisa Litovchick; Laurence A Florens; Selene K Swanson; Michael P Washburn; James A DeCaprio
Journal: Genes Dev Date: 2011-04-15 Impact factor: 11.361

Review 8. The RB and p53 pathways in cancer.

Authors: Charles J Sherr; Frank McCormick
Journal: Cancer Cell Date: 2002-08 Impact factor: 31.743

Sweet DREAMs for Hippo.

1. Extra-embryonic function of Rb is essential for embryonic development and viability.

2. Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes.

3. A kinase shRNA screen links LATS2 and the pRB tumor suppressor.

Review 4. The regulation of E2F by pRB-family proteins.

5. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

Review 6. The retinoblastoma tumour suppressor in development and cancer.

7. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.

Review 8. The RB and p53 pathways in cancer.

Review 9. New molecular tools for efficient screening of cervical cancer.

10. Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences.

Review 1. Mechanosensitive mechanisms in transcriptional regulation.

Review 2. Conserved RB functions in development and tumor suppression.

3. The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl.

4. The role of the hippo pathway in melanocytes and melanoma.