Literature DB >> 12459729

The retinoblastoma tumour suppressor in development and cancer.

Marie Classon1, Ed Harlow.   

Abstract

Since its discovery, the retinoblastoma (RB) tumour-suppressor protein has been a focal point of cancer research. Accumulating evidence indicates a complex role for RB in cell proliferation, differentiation and survival. To further complicate matters, proteins that are related to RB have redundant as well as antagonistic functions. Recent studies of knockout mice and cells that lack one or more of these proteins have begun to clarify their various context-specific functions and the unique activity of this tumour suppressor.

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Year:  2002        PMID： 12459729     DOI： 10.1038/nrc950

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  263 in total

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