| Literature DB >> 21536432 |
Bradley J Newhouse1, Joshua D Hansen, Jonas Grina, Mike Welch, George Topalov, Nicole Littman, Michele Callejo, Matthew Martinson, Sarah Galbraith, Ellen R Laird, Barbara J Brandhuber, Guy Vigers, Tony Morales, Rich Woessner, Nikole Randolph, Joseph Lyssikatos, Alan Olivero.
Abstract
The synthesis and biological evaluation of non-oxime pyrazole based B-Raf inhibitors is reported. Several oxime replacements have been prepared and have shown excellent enzyme activity. Further optimization of fused pyrazole 2a led to compound 38, a selective and potent B-Raf inhibitor.Entities:
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Year: 2010 PMID： 21536432 DOI： 10.1016/j.bmcl.2010.12.038
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823